BacMap

Definition	Methylobacterium radiotolerans JCM 2831 chromosome, complete genome.
Accession	NC_010505
Length	6,077,833

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The map label for this gene is phbB [H]

Identifier: 170751499

GI number: 170751499

Start: 5442047

End: 5442775

Strand: Direct

Name: phbB [H]

Synonym: Mrad2831_5119

Alternate gene names: 170751499

Gene position: 5442047-5442775 (Clockwise)

Preceding gene: 170751498

Following gene: 170751500

Centisome position: 89.54

GC content: 65.84

Gene sequence:

>729_bases
ATGGCTCAAGGACGCGTCGCCCTCGTGACGGGCGGCACCCGCGGCATCGGCGCGGCGATCTCGAAGCGGCTCAAGGACAA
GGGCTACAAGGTCGCCGCCAACTACGCCGGCAACGACGAGGCGGCCAACGCCTTCAAGGCCGAGACCGGCATCCCGGTCT
TCAAGTTCGACGTGGGTGATCTCGCGAGCTGCGAGGCCGGCATCAAGGCGATCGAGGCCGAACTCGGCCCGGTGGACATC
CTGGTGAACAACGCCGGCATCACCCGGGACGGCGCCTTCCACAAGATGACGTTCGAGAAGTGGCAGGCGGTCATCAAGAC
CAACCTCGACTCGATGTTCACCTGCACCCGTCCGCTGATCGAGGGCATGCGCAGCCGCAACTTCGGCCGCATCATCATCA
TCTCGTCGATCAACGGCCAGAAGGGCCAGGCCGGGCAGACCAACTACTCGGCCGCCAAGGCCGGCGTGATCGGTTTCGCC
AAGGCCCTGGCGCAGGAGAGCGCCTCGAAGGGCATCACCGTCAACGTGGTGGCGCCGGGCTACATCGCCACCGAGATGGT
GATGGCGGTGCCCGAGGACATCCGCAACAAGATCATCTCGACGATCCCGACCGGCCGCCTCGGCGAGTCCGACGAGATCG
CCCACGCGGTCGAGTATCTCGCCAGCGACGAGGCCGGCTTCGTGAACGGCTCGACACTGACCATCAACGGCGGCCAGCAC
TTCGTCTGA

Upstream 100 bases:

>100_bases
CAGTATCGGCTCACAACATAGACTTAAGGCCGAAGTCAGAAAAAATCGCGTGCGGACGCCATCCGCACGCGGCATCAAGT
GATGCGAACAGGAGGAAACA

Downstream 100 bases:

>100_bases
TCGCCGCGGGCGCGCCGGATCGAACCGGCGCGCCTGCCCTGTGGGCAAGTAGCCCCACCGCGTCGGGCGCGCATCTCTCC
GTCCGAAGAGCGTTCCTTCC

Product: acetoacetyl-CoA reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAQGRVALVTGGTRGIGAAISKRLKDKGYKVAANYAGNDEAANAFKAETGIPVFKFDVGDLASCEAGIKAIEAELGPVDI
LVNNAGITRDGAFHKMTFEKWQAVIKTNLDSMFTCTRPLIEGMRSRNFGRIIIISSINGQKGQAGQTNYSAAKAGVIGFA
KALAQESASKGITVNVVAPGYIATEMVMAVPEDIRNKIISTIPTGRLGESDEIAHAVEYLASDEAGFVNGSTLTINGGQH
FV

Sequences:

>Translated_242_residues
MAQGRVALVTGGTRGIGAAISKRLKDKGYKVAANYAGNDEAANAFKAETGIPVFKFDVGDLASCEAGIKAIEAELGPVDI
LVNNAGITRDGAFHKMTFEKWQAVIKTNLDSMFTCTRPLIEGMRSRNFGRIIIISSINGQKGQAGQTNYSAAKAGVIGFA
KALAQESASKGITVNVVAPGYIATEMVMAVPEDIRNKIISTIPTGRLGESDEIAHAVEYLASDEAGFVNGSTLTINGGQH
FV
>Mature_241_residues
AQGRVALVTGGTRGIGAAISKRLKDKGYKVAANYAGNDEAANAFKAETGIPVFKFDVGDLASCEAGIKAIEAELGPVDIL
VNNAGITRDGAFHKMTFEKWQAVIKTNLDSMFTCTRPLIEGMRSRNFGRIIIISSINGQKGQAGQTNYSAAKAGVIGFAK
ALAQESASKGITVNVVAPGYIATEMVMAVPEDIRNKIISTIPTGRLGESDEIAHAVEYLASDEAGFVNGSTLTINGGQHF
V

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=39.4190871369295, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=36.5853658536585, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=36.0576923076923, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=31.3492063492063, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=30.5785123966942, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=28.9915966386555, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI66933014, Length=172, Percent_Identity=33.7209302325581, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=29.2490118577075, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI109715829, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=31.1740890688259, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI5031737, Length=241, Percent_Identity=31.9502074688797, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=29.3650793650794, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI31542939, Length=260, Percent_Identity=30, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=32.4607329842932, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503817, Length=181, Percent_Identity=30.939226519337, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=25.9109311740891, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7657478, Length=193, Percent_Identity=30.0518134715026, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI157739938, Length=194, Percent_Identity=25.2577319587629, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI59889578, Length=206, Percent_Identity=31.0679611650485, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI226371731, Length=215, Percent_Identity=30.6976744186047, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7705855, Length=195, Percent_Identity=31.2820512820513, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI224922801, Length=171, Percent_Identity=33.9181286549708, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4503301, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI142976729, Length=217, Percent_Identity=24.8847926267281, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=32.9787234042553, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI44680136, Length=200, Percent_Identity=27, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI44680133, Length=200, Percent_Identity=27, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI17738292, Length=200, Percent_Identity=27, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI126723191, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=48.7603305785124, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=32.046332046332, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=35.9183673469388, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=31.9502074688797, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=31.5573770491803, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=36.7768595041322, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=31.404958677686, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1786812, Length=245, Percent_Identity=29.3877551020408, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787820, Length=223, Percent_Identity=31.8385650224215, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=28.740157480315, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=30.9917355371901, Blast_Score=77, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=43.3333333333333, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=38.0952380952381, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=33.739837398374, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17568967, Length=237, Percent_Identity=32.0675105485232, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=33.0645161290323, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=30.6451612903226, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=30.2788844621514, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=30.3643724696356, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=32.1138211382114, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=192, Percent_Identity=30.2083333333333, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=222, Percent_Identity=28.3783783783784, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=213, Percent_Identity=27.6995305164319, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=28.1853281853282, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=28.1853281853282, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=28.968253968254, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=28.0769230769231, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=28.1954887218045, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=26.7175572519084, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=23.7547892720307, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=27.5471698113208, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=27.2030651340996, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=270, Percent_Identity=28.5185185185185, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=27.9850746268657, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=27.9245283018868, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=27.0992366412214, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=38.5416666666667, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=26.6129032258064, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322227, Length=211, Percent_Identity=27.4881516587678, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320089, Length=200, Percent_Identity=29.5, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=36.0995850622407, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=34.0080971659919, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=31.8548387096774, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=33.8645418326693, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859837, Length=201, Percent_Identity=37.3134328358209, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=30.5785123966942, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=32.1285140562249, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=31.7829457364341, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24641232, Length=232, Percent_Identity=34.4827586206897, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=30.9623430962343, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI116007236, Length=223, Percent_Identity=30.4932735426009, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI116007238, Length=175, Percent_Identity=32, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571387, Length=234, Percent_Identity=28.6324786324786, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24641388, Length=233, Percent_Identity=30.4721030042918, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24644337, Length=180, Percent_Identity=31.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007234, Length=214, Percent_Identity=32.2429906542056, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=29.5336787564767, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355631, Length=168, Percent_Identity=29.7619047619048, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007232, Length=176, Percent_Identity=33.5227272727273, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24581726, Length=136, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=30.6878306878307, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=30.6878306878307, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649181, Length=202, Percent_Identity=31.6831683168317, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356301, Length=187, Percent_Identity=27.807486631016, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574402, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584744, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011283
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.36 [H]

Molecular weight: Translated: 25427; Mature: 25296

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGRVALVTGGTRGIGAAISKRLKDKGYKVAANYAGNDEAANAFKAETGIPVFKFDVGD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCC
LASCEAGIKAIEAELGPVDILVNNAGITRDGAFHKMTFEKWQAVIKTNLDSMFTCTRPLI
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
EGMRSRNFGRIIIISSINGQKGQAGQTNYSAAKAGVIGFAKALAQESASKGITVNVVAPG
HHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
YIATEMVMAVPEDIRNKIISTIPTGRLGESDEIAHAVEYLASDEAGFVNGSTLTINGGQH
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEECCCEEEECCCCC
FV
CC
>Mature Secondary Structure 
AQGRVALVTGGTRGIGAAISKRLKDKGYKVAANYAGNDEAANAFKAETGIPVFKFDVGD
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCC
LASCEAGIKAIEAELGPVDILVNNAGITRDGAFHKMTFEKWQAVIKTNLDSMFTCTRPLI
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
EGMRSRNFGRIIIISSINGQKGQAGQTNYSAAKAGVIGFAKALAQESASKGITVNVVAPG
HHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
YIATEMVMAVPEDIRNKIISTIPTGRLGESDEIAHAVEYLASDEAGFVNGSTLTINGGQH
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEECCCEEEECCCCC
FV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2546004; 3286259 [H]