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The map label for this gene is adk

Identifier: 170748615

GI number: 170748615

Start: 2340460

End: 2341062

Strand: Reverse

Name: adk

Synonym: Mrad2831_2197

Alternate gene names: 170748615

Gene position: 2341062-2340460 (Counterclockwise)

Preceding gene: 170748616

Following gene: 170748614

Centisome position: 38.52

GC content: 71.64

Gene sequence:

>603_bases
ATGCGTATCATTCTGCTCGGGCCGCCCGGTGCGGGGAAGGGGACGCAATCCGAGCGGATCGTACAGCGCTTCGGCATCCC
GCAGCTCTCCACCGGCGACATGCTCCGCGCCGCGGTGGCCGCCGGCACGCCGGTCGGCCTCGAGGCCAAGGCCGTGATGG
AATCCGGCGGCCTCGTCTCCGACCGGATCGTCGTCGGCATCGTCGCCGACCGGATCGAGGAGCCGGACGCCCGCCGCGGC
TTCATCCTCGACGGCTTCCCGCGCACGGTCGCGCAGGCCGAGGCGCTCGGCGAGATGCTCGCCAGCAAGGGTCTGAGCCT
CTCCGCGGTCGTCGAGCTGAAGGTCGACGAGAACGCCCTGGTCGGCCGCATCGAGAAGCGCGCCGCCGAGACCCTGGCCC
GCGGCCAGGCCGTGCGGAAGGACGACACGCCGGAGGTGTTCAAGCAGCGGCTCGAGGCCTACCGCGCCCAGACGGCGCCC
CTCTCCGCCTACTACGCGCAGAAGGGCACGCTGGAGACCGTCGACGGCATGCAGCCGATCGACAAGGTCACCGCCGACCT
GATGGCGGTGCTGGAGCCCCACGAGGAGCGCGTCGCTTCCTGA

Upstream 100 bases:

>100_bases
GCCCGGACCGGCTAGAAAATCCCGAACCCGGCGATGCCAGGGAGGCTTCGCCACCACGGCTTGTGCCCACTGAGAGAGTG
GGCCGAACGAGGACAACGCC

Downstream 100 bases:

>100_bases
AGCGATCGCGGCGCGCTGACCGATAAGTGAAGCGCGCCCGTGAACCCGGCGCGATCGCGGAGGGTTATGGGGCGGATCCA
CGATCGGAAACGCCATGACC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MRIILLGPPGAGKGTQSERIVQRFGIPQLSTGDMLRAAVAAGTPVGLEAKAVMESGGLVSDRIVVGIVADRIEEPDARRG
FILDGFPRTVAQAEALGEMLASKGLSLSAVVELKVDENALVGRIEKRAAETLARGQAVRKDDTPEVFKQRLEAYRAQTAP
LSAYYAQKGTLETVDGMQPIDKVTADLMAVLEPHEERVAS

Sequences:

>Translated_200_residues
MRIILLGPPGAGKGTQSERIVQRFGIPQLSTGDMLRAAVAAGTPVGLEAKAVMESGGLVSDRIVVGIVADRIEEPDARRG
FILDGFPRTVAQAEALGEMLASKGLSLSAVVELKVDENALVGRIEKRAAETLARGQAVRKDDTPEVFKQRLEAYRAQTAP
LSAYYAQKGTLETVDGMQPIDKVTADLMAVLEPHEERVAS
>Mature_200_residues
MRIILLGPPGAGKGTQSERIVQRFGIPQLSTGDMLRAAVAAGTPVGLEAKAVMESGGLVSDRIVVGIVADRIEEPDARRG
FILDGFPRTVAQAEALGEMLASKGLSLSAVVELKVDENALVGRIEKRAAETLARGQAVRKDDTPEVFKQRLEAYRAQTAP
LSAYYAQKGTLETVDGMQPIDKVTADLMAVLEPHEERVAS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=38.8888888888889, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI7524346, Length=216, Percent_Identity=38.8888888888889, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI19923437, Length=214, Percent_Identity=32.2429906542056, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4502011, Length=192, Percent_Identity=34.375, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=31.8407960199005, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=31.8407960199005, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=31.8407960199005, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=31.8407960199005, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI28144897, Length=174, Percent_Identity=32.183908045977, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI28144899, Length=174, Percent_Identity=32.183908045977, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI7706497, Length=196, Percent_Identity=25.5102040816327, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=41.0138248847926, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17552384, Length=224, Percent_Identity=37.5, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=192, Percent_Identity=34.8958333333333, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=191, Percent_Identity=29.8429319371728, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=195, Percent_Identity=29.2307692307692, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=28, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=43.1924882629108, Blast_Score=171, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6321018, Length=199, Percent_Identity=37.1859296482412, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=39.3364928909953, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.6733668341709, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.6733668341709, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24663208, Length=203, Percent_Identity=33.0049261083744, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17647141, Length=203, Percent_Identity=33.0049261083744, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221459597, Length=192, Percent_Identity=26.5625, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356893, Length=192, Percent_Identity=26.5625, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_METRJ (B1LWQ5)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001754875.1
- ProteinModelPortal:   B1LWQ5
- SMR:   B1LWQ5
- GeneID:   6138229
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_2197
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21336; Mature: 21336

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGPPGAGKGTQSERIVQRFGIPQLSTGDMLRAAVAAGTPVGLEAKAVMESGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DRIVVGIVADRIEEPDARRGFILDGFPRTVAQAEALGEMLASKGLSLSAVVELKVDENAL
HHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHH
VGRIEKRAAETLARGQAVRKDDTPEVFKQRLEAYRAQTAPLSAYYAQKGTLETVDGMQPI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCCCHH
DKVTADLMAVLEPHEERVAS
HHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MRIILLGPPGAGKGTQSERIVQRFGIPQLSTGDMLRAAVAAGTPVGLEAKAVMESGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DRIVVGIVADRIEEPDARRGFILDGFPRTVAQAEALGEMLASKGLSLSAVVELKVDENAL
HHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHH
VGRIEKRAAETLARGQAVRKDDTPEVFKQRLEAYRAQTAPLSAYYAQKGTLETVDGMQPI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCCCHH
DKVTADLMAVLEPHEERVAS
HHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA