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The map label for this gene is nuoD [H]

Identifier: 170748475

GI number: 170748475

Start: 2188103

End: 2189293

Strand: Reverse

Name: nuoD [H]

Synonym: Mrad2831_2057

Alternate gene names: 170748475

Gene position: 2189293-2188103 (Counterclockwise)

Preceding gene: 170748476

Following gene: 170748474

Centisome position: 36.02

GC content: 66.58

Gene sequence:

>1191_bases
GTGACCGAACACAACATCCGCAACTTCGCGATCAACTTCGGCCCGCAGCACCCGGCGGCGCACGGGGTGCTGCGCCTCGT
GCTCGAACTCGACGGCGAGGTGGTCGAGCGGGTCGACCCGCATATCGGGCTGCTCCACCGCGGCACCGAGAAGCTGATCG
AGTACAAGACCTACCTGCAGGCGACGCCCTATTTCGACCGGCTCGACTACGTGTCGCCGATGAACCAGGAGCACGCCTTC
TGCCTGGCGATCGAGAAGCTCGCCGGGATCGAGGTGCCGCGGCGCGCGCAGCTGATCCGCGTGCTGTTCTGCGAGATCGG
CCGCCTACTGTCGCACCTGCTCAACGTCACCACGCAGGCGATGGACGTCGGCGCCCTCACGCCCCCGCTCTGGGGCTTCG
AGGAGCGCGAGAAGCTGATGATCTTCTACGAGCGGGCCTCCGGCGCCCGGCTCCACGCCAACTACTTCCGGCCGGGCGGC
GTCCACCAGGACCTGCCGCCAAAGCTCATCGACGACATCGACGCGTTCTGCGACCCGTTCCTGCAGGTCGTCCAGGACCT
CGACGACCTCGTCATGGCCAACCGCATCTTCAAGCAGCGCAACGTCGATATCGGCATCGTGTCGGTGGACGAGGCGATGC
AGTGGGGCTTCTCGGGCGTGATGGTGCGCGGCTCGGGCATCCCGTGGGACCTGCGCAAGGCGCAGCCCTACGAGTGCTAC
GAGGAGATGGAATTCGACGTCCCCGTCGGGAAGAACGGCGACACCTACGATCGTCAGGTGATCCGCATGGAGGAGATGCG
CCAGTCGGTGCGCATCATGAAGCAGTGCGTCGCCAAGCTGCGCGAGCCCGCCGGCCAGGGGCCGATCGCCTCCGTCGACG
GCAAGTTCGCGCCGCCGCCACGCCGGGAGATGAAGCGCTCGATGGAGGCGCTCATCCACCACTTCAAGCTCTACACCGAG
GGCTTCCACGTGCCCGAGGGCGAGGTCTACGCCGCGGTCGAGGCGCCGAAGGGCGAGTTCGGCGTGTATCTGGTGTCCGA
CGGCACCAACAAGCCGTATCGCTGCAAGATCCGCGCGCCGGGCTTCGCGCATCTTCAGGCGATGGACTGGATGTGCCGCG
GGCACCTCTTAGCCGACGTGTCCTGCGTGCTCGGCACGCTCGACATCGTGTTCGGCGAAGTGGATCGGTAA

Upstream 100 bases:

>100_bases
CAGGAATTCCGGAACTTCGACTTCTTGTCGCCGTGGGAAGGCACCGACTACGTGCTGCCCGGCGACGAGAAGACGTCGGC
ATGAGCCGCGGAGACCGTCC

Downstream 100 bases:

>100_bases
GACAGAAGCGATGGCAAACCGCAGACTCGCCCCCGCCTCGGAGCAGCCCGAGAGCTTCGCGTTCTCCCCCGAGAACGCCG
AGTGGGCCAAGACCCAGATC

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTEHNIRNFAINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQATPYFDRLDYVSPMNQEHAF
CLAIEKLAGIEVPRRAQLIRVLFCEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGG
VHQDLPPKLIDDIDAFCDPFLQVVQDLDDLVMANRIFKQRNVDIGIVSVDEAMQWGFSGVMVRGSGIPWDLRKAQPYECY
EEMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCVAKLREPAGQGPIASVDGKFAPPPRREMKRSMEALIHHFKLYTE
GFHVPEGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDWMCRGHLLADVSCVLGTLDIVFGEVDR

Sequences:

>Translated_396_residues
MTEHNIRNFAINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQATPYFDRLDYVSPMNQEHAF
CLAIEKLAGIEVPRRAQLIRVLFCEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGG
VHQDLPPKLIDDIDAFCDPFLQVVQDLDDLVMANRIFKQRNVDIGIVSVDEAMQWGFSGVMVRGSGIPWDLRKAQPYECY
EEMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCVAKLREPAGQGPIASVDGKFAPPPRREMKRSMEALIHHFKLYTE
GFHVPEGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDWMCRGHLLADVSCVLGTLDIVFGEVDR
>Mature_395_residues
TEHNIRNFAINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQATPYFDRLDYVSPMNQEHAFC
LAIEKLAGIEVPRRAQLIRVLFCEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGGV
HQDLPPKLIDDIDAFCDPFLQVVQDLDDLVMANRIFKQRNVDIGIVSVDEAMQWGFSGVMVRGSGIPWDLRKAQPYECYE
EMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCVAKLREPAGQGPIASVDGKFAPPPRREMKRSMEALIHHFKLYTEG
FHVPEGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDWMCRGHLLADVSCVLGTLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=65.2173913043478, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=64.4155844155844, Blast_Score=512, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.5348837209302, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1789076, Length=392, Percent_Identity=26.530612244898, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788832, Length=398, Percent_Identity=25.8793969849246, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=62.6903553299492, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=61.4213197969543, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=63.4517766497462, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221459469, Length=395, Percent_Identity=56.7088607594937, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44967; Mature: 44836

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHNIRNFAINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQ
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
ATPYFDRLDYVSPMNQEHAFCLAIEKLAGIEVPRRAQLIRVLFCEIGRLLSHLLNVTTQA
CCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGGVHQDLPPKLIDDIDAFCDPF
HHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LQVVQDLDDLVMANRIFKQRNVDIGIVSVDEAMQWGFSGVMVRGSGIPWDLRKAQPYECY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHH
EEMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCVAKLREPAGQGPIASVDGKFAPPP
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCC
RREMKRSMEALIHHFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GFAHLQAMDWMCRGHLLADVSCVLGTLDIVFGEVDR
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEHNIRNFAINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
ATPYFDRLDYVSPMNQEHAFCLAIEKLAGIEVPRRAQLIRVLFCEIGRLLSHLLNVTTQA
CCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMIFYERASGARLHANYFRPGGVHQDLPPKLIDDIDAFCDPF
HHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LQVVQDLDDLVMANRIFKQRNVDIGIVSVDEAMQWGFSGVMVRGSGIPWDLRKAQPYECY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHH
EEMEFDVPVGKNGDTYDRQVIRMEEMRQSVRIMKQCVAKLREPAGQGPIASVDGKFAPPP
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCC
RREMKRSMEALIHHFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GFAHLQAMDWMCRGHLLADVSCVLGTLDIVFGEVDR
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA