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The map label for this gene is nqo2 [H]

Identifier: 170748474

GI number: 170748474

Start: 2186719

End: 2188092

Strand: Reverse

Name: nqo2 [H]

Synonym: Mrad2831_2056

Alternate gene names: 170748474

Gene position: 2188092-2186719 (Counterclockwise)

Preceding gene: 170748475

Following gene: 170748473

Centisome position: 36.0

GC content: 74.31

Gene sequence:

>1374_bases
ATGGCAAACCGCAGACTCGCCCCCGCCTCGGAGCAGCCCGAGAGCTTCGCGTTCTCCCCCGAGAACGCCGAGTGGGCCAA
GACCCAGATCGCCAAGTACCCCGAAGGCCGTCAGGCCTCCGCGGTGATCTCGCTGCTCTGGCGGGCGCAGGAGCAGAACG
GCGGCTGGCTGCCGCGCGCGGCCATCGAGGCGGTGGCGGCCGAGCTCGGCATGCCGAACATCCGCGTGCTGGAGGTGGCG
ACCTTCTACACGATGTTCGCCCTGGAGCCGGTCGGGCGGTTCTGGATCCAGGTCTGCGGCACGGTCCCGTGCGATTCCTG
CGGCGCGCGGGGCCTCAAGGAGATGCTCCAGGCCCGCCTCGGACCGGCCGGCCACGTCTCGGCCGACGGCAACTTCTCGT
GGCTCGAGGTCGAGTGCCTCGGCGCCTGCTGCAACGCGCCGATGGTCCAGATCAACCAGGATTACTACGAGGACCTGACG
CCTGAGTCCCTCGGCCAGCTGATGGACGACCTCGCCGCCGGCCGGCCCGTGAAGGTCGGCTCGCAGACCGGGCGCGTCTC
GTCCGAGCCCCAGGGCGCCGTGAACACCCTCACCGACCCGACGCTGTTCGACGGGTCGCGTGTCGGCGCGTGGCGCAAGC
GCTTCGAGGAGGCCGGCAAGGCCGAGGAGCCGGCCGCCGCGCCAGTGTCCAAGACCGGCGAGGCGGCTTCCGGAACCCAG
CAGGCCGCCGAGAACCCGAAGCCGGCGCGGCCCGATGCCGGCCGCCCGGTGGAGCGCACGGTCACCGATGCGCCGGCCCA
GCGCGCCGCCGACGGCGAGACGCCGGTCAAGCCCGAGGATCGCGCGGACGCGGCCGAGCGCGGCCGGTCCACCGCCAAGC
ACGGCGCCGCCCGCCAGGGCGACGCGGACGTGCTCGACTCGCCGGCCAAGCGCGTCGCCGAGGGCGAGCCCGCGGCCGGC
GAGCAGGGCCACCAGGCGGTGCCGGACCGCGACGCCGTCCCGCAGCAGCCGGAAGCCTCTGGGGCCAGCGAGGGCGAGAT
GGCGGCCGAGGCCGAGGAGGCCCGCATCGCCGGCGCCCTCGCGGCCCTGCCGAAGGATGCCAGCCCCGAGCAGAAGGCGG
ACGCCGTGGGCGAGCGCCCGCCGGGCCTCGACGCGGCCCGCGCCGGGAAGCCGGACGAGCTGACGCGCATCAAGGGCATC
GGCCCGGGCAACAGCCAGCGCCTGAACGGGCTCGGCATCTACCACTTCGACCAGATCGCCGCCTGGTCCCGCGACGAGAT
CGCCTGGGTCGGCACCTACCTCGCGTTCCCGGGTCGCATCGACCGCGAGAACTGGGTGGGGCAGGCCAAGGCCCTGTCGG
CGCCGGCTCAGTGA

Upstream 100 bases:

>100_bases
ATGGACTGGATGTGCCGCGGGCACCTCTTAGCCGACGTGTCCTGCGTGCTCGGCACGCTCGACATCGTGTTCGGCGAAGT
GGATCGGTAAGACAGAAGCG

Downstream 100 bases:

>100_bases
GGACCTGACATGCTGTCGGATCAGGATCGCATCTTCACCAACCTCTACGGGCTGCACTCGCCGGGCCTGGAGGCCGCCAA
GAAGCGCGGCGCGTGGGACG

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MANRRLAPASEQPESFAFSPENAEWAKTQIAKYPEGRQASAVISLLWRAQEQNGGWLPRAAIEAVAAELGMPNIRVLEVA
TFYTMFALEPVGRFWIQVCGTVPCDSCGARGLKEMLQARLGPAGHVSADGNFSWLEVECLGACCNAPMVQINQDYYEDLT
PESLGQLMDDLAAGRPVKVGSQTGRVSSEPQGAVNTLTDPTLFDGSRVGAWRKRFEEAGKAEEPAAAPVSKTGEAASGTQ
QAAENPKPARPDAGRPVERTVTDAPAQRAADGETPVKPEDRADAAERGRSTAKHGAARQGDADVLDSPAKRVAEGEPAAG
EQGHQAVPDRDAVPQQPEASGASEGEMAAEAEEARIAGALAALPKDASPEQKADAVGERPPGLDAARAGKPDELTRIKGI
GPGNSQRLNGLGIYHFDQIAAWSRDEIAWVGTYLAFPGRIDRENWVGQAKALSAPAQ

Sequences:

>Translated_457_residues
MANRRLAPASEQPESFAFSPENAEWAKTQIAKYPEGRQASAVISLLWRAQEQNGGWLPRAAIEAVAAELGMPNIRVLEVA
TFYTMFALEPVGRFWIQVCGTVPCDSCGARGLKEMLQARLGPAGHVSADGNFSWLEVECLGACCNAPMVQINQDYYEDLT
PESLGQLMDDLAAGRPVKVGSQTGRVSSEPQGAVNTLTDPTLFDGSRVGAWRKRFEEAGKAEEPAAAPVSKTGEAASGTQ
QAAENPKPARPDAGRPVERTVTDAPAQRAADGETPVKPEDRADAAERGRSTAKHGAARQGDADVLDSPAKRVAEGEPAAG
EQGHQAVPDRDAVPQQPEASGASEGEMAAEAEEARIAGALAALPKDASPEQKADAVGERPPGLDAARAGKPDELTRIKGI
GPGNSQRLNGLGIYHFDQIAAWSRDEIAWVGTYLAFPGRIDRENWVGQAKALSAPAQ
>Mature_456_residues
ANRRLAPASEQPESFAFSPENAEWAKTQIAKYPEGRQASAVISLLWRAQEQNGGWLPRAAIEAVAAELGMPNIRVLEVAT
FYTMFALEPVGRFWIQVCGTVPCDSCGARGLKEMLQARLGPAGHVSADGNFSWLEVECLGACCNAPMVQINQDYYEDLTP
ESLGQLMDDLAAGRPVKVGSQTGRVSSEPQGAVNTLTDPTLFDGSRVGAWRKRFEEAGKAEEPAAAPVSKTGEAASGTQQ
AAENPKPARPDAGRPVERTVTDAPAQRAADGETPVKPEDRADAAERGRSTAKHGAARQGDADVLDSPAKRVAEGEPAAGE
QGHQAVPDRDAVPQQPEASGASEGEMAAEAEEARIAGALAALPKDASPEQKADAVGERPPGLDAARAGKPDELTRIKGIG
PGNSQRLNGLGIYHFDQIAAWSRDEIAWVGTYLAFPGRIDRENWVGQAKALSAPAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=198, Percent_Identity=46.4646464646465, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1788621, Length=159, Percent_Identity=36.4779874213836, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=185, Percent_Identity=49.1891891891892, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI18859877, Length=185, Percent_Identity=45.945945945946, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21355353, Length=184, Percent_Identity=36.4130434782609, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48341; Mature: 48210

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRRLAPASEQPESFAFSPENAEWAKTQIAKYPEGRQASAVISLLWRAQEQNGGWLPRA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHH
AIEAVAAELGMPNIRVLEVATFYTMFALEPVGRFWIQVCGTVPCDSCGARGLKEMLQARL
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
GPAGHVSADGNFSWLEVECLGACCNAPMVQINQDYYEDLTPESLGQLMDDLAAGRPVKVG
CCCCCCCCCCCCEEEEHHHHHHHCCCCEEEECHHHHHCCCHHHHHHHHHHHHCCCCEEEC
SQTGRVSSEPQGAVNTLTDPTLFDGSRVGAWRKRFEEAGKAEEPAAAPVSKTGEAASGTQ
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QAAENPKPARPDAGRPVERTVTDAPAQRAADGETPVKPEDRADAAERGRSTAKHGAARQG
HHHCCCCCCCCCCCCCHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCC
DADVLDSPAKRVAEGEPAAGEQGHQAVPDRDAVPQQPEASGASEGEMAAEAEEARIAGAL
CHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AALPKDASPEQKADAVGERPPGLDAARAGKPDELTRIKGIGPGNSQRLNGLGIYHFDQIA
HHCCCCCCCHHHHHHCCCCCCCCCHHHCCCCHHHHEEECCCCCCCCCCCCEEEEEHHHHH
AWSRDEIAWVGTYLAFPGRIDRENWVGQAKALSAPAQ
HCCCCCCHHHHHHHHCCCCCCHHHHHCHHHHCCCCCC
>Mature Secondary Structure 
ANRRLAPASEQPESFAFSPENAEWAKTQIAKYPEGRQASAVISLLWRAQEQNGGWLPRA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHH
AIEAVAAELGMPNIRVLEVATFYTMFALEPVGRFWIQVCGTVPCDSCGARGLKEMLQARL
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
GPAGHVSADGNFSWLEVECLGACCNAPMVQINQDYYEDLTPESLGQLMDDLAAGRPVKVG
CCCCCCCCCCCCEEEEHHHHHHHCCCCEEEECHHHHHCCCHHHHHHHHHHHHCCCCEEEC
SQTGRVSSEPQGAVNTLTDPTLFDGSRVGAWRKRFEEAGKAEEPAAAPVSKTGEAASGTQ
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QAAENPKPARPDAGRPVERTVTDAPAQRAADGETPVKPEDRADAAERGRSTAKHGAARQG
HHHCCCCCCCCCCCCCHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCC
DADVLDSPAKRVAEGEPAAGEQGHQAVPDRDAVPQQPEASGASEGEMAAEAEEARIAGAL
CHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AALPKDASPEQKADAVGERPPGLDAARAGKPDELTRIKGIGPGNSQRLNGLGIYHFDQIA
HHCCCCCCCHHHHHHCCCCCCCCCHHHCCCCHHHHEEECCCCCCCCCCCCEEEEEHHHHH
AWSRDEIAWVGTYLAFPGRIDRENWVGQAKALSAPAQ
HCCCCCCHHHHHHHHCCCCCCHHHHHCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]