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The map label for this gene is folK [H]

Identifier: 170746945

GI number: 170746945

Start: 549982

End: 550452

Strand: Reverse

Name: folK [H]

Synonym: Mrad2831_0511

Alternate gene names: 170746945

Gene position: 550452-549982 (Counterclockwise)

Preceding gene: 170746946

Following gene: 170746938

Centisome position: 9.06

GC content: 71.34

Gene sequence:

>471_bases
ATGAGGGCGTATCTCGGCATCGGCAGCAATGTCGGCGACATGGCCGCGATGCTCGACCGCGCGGTCACCGGCCTCGCGGC
GATCCCGGGCATCGACGTCGTGGCGCGCTCGGCCGACTATCGGACGCCGCCCTGGGGCAAGACCGATCAGCCGTGGTTCC
TCAACGGCGCCGTGGCGGTGGAGACGGAGCTGGATCCACACGGCCTGCTCGACGCCTGTCTGCGGGTGGAGCACGACCTC
GGCCGGATCCGCGAGGAGCGCTGGGGGCCGCGGGTGATCGACATCGATGTCCTGGCCTACGAAGGTGCCAGCATCGACGA
CGCTCGCCTCGTGCTGCCGCACCGCTACGTGCGCGAGCGGGCCTTCGTGCTGGTTCCCCTGGCCGAGATCGCGCCGGACC
TCGTCATCGGCGGCGAGCGCGTGGTGGATGCCCTGGCGAAGCTCGACCGGACCGGCATCGCGCGCGCCTGA

Upstream 100 bases:

>100_bases
TCGCGGCGATCACCGTGCAGGTCGACAAGCCGAGCGCGCCCGTCCCCGCCATCCTGGACAGCGTCGGCGTCGCGATCACG
CGCCGCCGCGGGGCGAGCCG

Downstream 100 bases:

>100_bases
CCGCGGCCCGCGGCGGCGCGTCAGCGCTCGCCGGGGGCGACGAGCTTGTTCTCTTCCTCGTCGAGGAGCGGCACGTCGTA
GTCGCGCAGGACCTTGTCGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MRAYLGIGSNVGDMAAMLDRAVTGLAAIPGIDVVARSADYRTPPWGKTDQPWFLNGAVAVETELDPHGLLDACLRVEHDL
GRIREERWGPRVIDIDVLAYEGASIDDARLVLPHRYVRERAFVLVPLAEIAPDLVIGGERVVDALAKLDRTGIARA

Sequences:

>Translated_156_residues
MRAYLGIGSNVGDMAAMLDRAVTGLAAIPGIDVVARSADYRTPPWGKTDQPWFLNGAVAVETELDPHGLLDACLRVEHDL
GRIREERWGPRVIDIDVLAYEGASIDDARLVLPHRYVRERAFVLVPLAEIAPDLVIGGERVVDALAKLDRTGIARA
>Mature_156_residues
MRAYLGIGSNVGDMAAMLDRAVTGLAAIPGIDVVARSADYRTPPWGKTDQPWFLNGAVAVETELDPHGLLDACLRVEHDL
GRIREERWGPRVIDIDVLAYEGASIDDARLVLPHRYVRERAFVLVPLAEIAPDLVIGGERVVDALAKLDRTGIARA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=44.4444444444444, Blast_Score=121, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324073, Length=156, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17006; Mature: 17006

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYLGIGSNVGDMAAMLDRAVTGLAAIPGIDVVARSADYRTPPWGKTDQPWFLNGAVAV
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCCEEECCEEEE
ETELDPHGLLDACLRVEHDLGRIREERWGPRVIDIDVLAYEGASIDDARLVLPHRYVRER
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEECCHHHHHCC
AFVLVPLAEIAPDLVIGGERVVDALAKLDRTGIARA
EEEEEEHHHHCCCCEECHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRAYLGIGSNVGDMAAMLDRAVTGLAAIPGIDVVARSADYRTPPWGKTDQPWFLNGAVAV
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCCEEECCEEEE
ETELDPHGLLDACLRVEHDLGRIREERWGPRVIDIDVLAYEGASIDDARLVLPHRYVRER
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCEEECCHHHHHCC
AFVLVPLAEIAPDLVIGGERVVDALAKLDRTGIARA
EEEEEEHHHHCCCCEECHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]