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The map label for this gene is comP [H]

Identifier: 170746768

GI number: 170746768

Start: 352110

End: 353540

Strand: Reverse

Name: comP [H]

Synonym: Mrad2831_0321

Alternate gene names: 170746768

Gene position: 353540-352110 (Counterclockwise)

Preceding gene: 170746776

Following gene: 170746767

Centisome position: 5.82

GC content: 71.91

Gene sequence:

>1431_bases
GTGACGACCTTCAGCCTCAAGCACGTCCTGGCCGCCTGGGACGCGCGCGAGCTGGATCTCAAATGGGCTCTCGTCGGCCG
GATCGCGCTGATCGCCATCCTCTGCGCCGCCGGAGCGGCCGCGTACGCCATGCACGACGTCGCGGCGAAGACCAGGCAGC
GAAACGCCGAGACGGCCGGCGAAGTGCACAAGCAACTTCGCCTGCAGCTCCTGCGCATCGAGCGGGCCGCCGACATTCCC
GTACGCTTTCCGGACTGGGAGATCGTCACCCGGTACGCCCTGCAACCCGGTCAGTGCGTGCAGCTGATCCCGGCGGAGAC
CGGCCCGACACGGTCGAGCTGCGTCGGCGTCGAGCCGCACGCGCTCGCGGCACCCGACTGGTTCGCGACGCTCTACAGGT
CCCTCTTCTTCGCCGGATCCACCGTCCGTCTGCCGCTCGAGCATCAGGGCTCGCGGAGAGGGATCGTGGAGGCGGACATC
GATCCGCACGCCGTCGTCGGTTCGGCCTGGATCGTGCTGAAGCAGGTCTCCGGCGCGCTCGCGGCCATGACGGTCGTCCT
GTGCGTGCTGGTCTACGGCGCGGTCGCGCACGCCCTGCGTCCCGCCAATGAGATCCTTGTCGGTATCGACCGCGTCGCGC
AGGGCGACCTCGCGTGGCGTCTGCCGAGCTTCCGCCTGCGCGAGCTCCGGCGCATTGCGACGGTGTTCAACGCGCTTGCC
GGCCATCTCCAGCTGGCCACACGGGAGCGCGCCGAGCTCGCCCGCCGGCTGATCGATGCCCAGGAGCAAGAGCGCCGGTG
GCTGTCGCTCGAACTGCACGACGACGTGGCGCAGAGGCTGACGGCCCTGAGTCTCCTCGCCCGCTCGATCCAGGACGGCG
CGCGCTCCGCGGCGCCTTCGGTCTCGACCGAGAGCGCCGAACTCGCCAGCATGGCATCGGACGCGGTGCGGGCGCTCCGG
ATCACCCTGGCCTCGCTGCGGCCGCCGGAGATCGACGATCTCGGGCTGCGGATCGCGCTCCGCAGCCTGATCGCCGCGCA
GGCGCAGCGGGCCAGCGGCCGGATCCAAGTCGCGCTGCGGGCCGACGCGCAGGTCGACCGCCTGCCCTCAGAGGCGGCGG
CCCATGTCTACCGGATCGTCCAGGAAGGCCTCACCAACGCCGTCCGCCACGCGGCGGCACGCAACGTGGCGATCGCGCTG
AACGTCGTGGAGACCGACGGCGGTGCGGACGTCCGGCTGGACTTCGCCGACGACGGGAGCGGCGCGCCCGCGGAGGTGCT
GGAGCGCCCGCGTCCCGGTCTCGGCCTGCTCGGCATGCGCGACCGCGTCCACGCGCTCGGCGGGCAGATCGTGACGGAAA
CGTCCCCGGGCGGCGGGTTTCGCCTGCGGGTCCGCTTTCGCGCCGCGCTCGCGGCCAGGGAGGTGTCATGA

Upstream 100 bases:

>100_bases
AGAACGCCCGCGTTGACCTGGGCAAATCGCACGACTTCAGCGCGGACCCTTCCAAGACGGTCGCAAGCTCGATAACCCTC
GGCCTCTCGGGAGGACACGG

Downstream 100 bases:

>100_bases
CCGGACGGCGCATACGGGTGATGCTCGTCGACGATCACGCCGTCGTACGGGAGGGATACCGGCGGCTCCTGGAACGACAG
CCCGATATGGAGGTCGCCGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTTFSLKHVLAAWDARELDLKWALVGRIALIAILCAAGAAAYAMHDVAAKTRQRNAETAGEVHKQLRLQLLRIERAADIP
VRFPDWEIVTRYALQPGQCVQLIPAETGPTRSSCVGVEPHALAAPDWFATLYRSLFFAGSTVRLPLEHQGSRRGIVEADI
DPHAVVGSAWIVLKQVSGALAAMTVVLCVLVYGAVAHALRPANEILVGIDRVAQGDLAWRLPSFRLRELRRIATVFNALA
GHLQLATRERAELARRLIDAQEQERRWLSLELHDDVAQRLTALSLLARSIQDGARSAAPSVSTESAELASMASDAVRALR
ITLASLRPPEIDDLGLRIALRSLIAAQAQRASGRIQVALRADAQVDRLPSEAAAHVYRIVQEGLTNAVRHAAARNVAIAL
NVVETDGGADVRLDFADDGSGAPAEVLERPRPGLGLLGMRDRVHALGGQIVTETSPGGGFRLRVRFRAALAAREVS

Sequences:

>Translated_476_residues
MTTFSLKHVLAAWDARELDLKWALVGRIALIAILCAAGAAAYAMHDVAAKTRQRNAETAGEVHKQLRLQLLRIERAADIP
VRFPDWEIVTRYALQPGQCVQLIPAETGPTRSSCVGVEPHALAAPDWFATLYRSLFFAGSTVRLPLEHQGSRRGIVEADI
DPHAVVGSAWIVLKQVSGALAAMTVVLCVLVYGAVAHALRPANEILVGIDRVAQGDLAWRLPSFRLRELRRIATVFNALA
GHLQLATRERAELARRLIDAQEQERRWLSLELHDDVAQRLTALSLLARSIQDGARSAAPSVSTESAELASMASDAVRALR
ITLASLRPPEIDDLGLRIALRSLIAAQAQRASGRIQVALRADAQVDRLPSEAAAHVYRIVQEGLTNAVRHAAARNVAIAL
NVVETDGGADVRLDFADDGSGAPAEVLERPRPGLGLLGMRDRVHALGGQIVTETSPGGGFRLRVRFRAALAAREVS
>Mature_475_residues
TTFSLKHVLAAWDARELDLKWALVGRIALIAILCAAGAAAYAMHDVAAKTRQRNAETAGEVHKQLRLQLLRIERAADIPV
RFPDWEIVTRYALQPGQCVQLIPAETGPTRSSCVGVEPHALAAPDWFATLYRSLFFAGSTVRLPLEHQGSRRGIVEADID
PHAVVGSAWIVLKQVSGALAAMTVVLCVLVYGAVAHALRPANEILVGIDRVAQGDLAWRLPSFRLRELRRIATVFNALAG
HLQLATRERAELARRLIDAQEQERRWLSLELHDDVAQRLTALSLLARSIQDGARSAAPSVSTESAELASMASDAVRALRI
TLASLRPPEIDDLGLRIALRSLIAAQAQRASGRIQVALRADAQVDRLPSEAAAHVYRIVQEGLTNAVRHAAARNVAIALN
VVETDGGADVRLDFADDGSGAPAEVLERPRPGLGLLGMRDRVHALGGQIVTETSPGGGFRLRVRFRAALAAREVS

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=35.8078602620087, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788812, Length=283, Percent_Identity=27.5618374558304, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787474, Length=210, Percent_Identity=29.0476190476191, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51466; Mature: 51335

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSLKHVLAAWDARELDLKWALVGRIALIAILCAAGAAAYAMHDVAAKTRQRNAETAG
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
EVHKQLRLQLLRIERAADIPVRFPDWEIVTRYALQPGQCVQLIPAETGPTRSSCVGVEPH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
ALAAPDWFATLYRSLFFAGSTVRLPLEHQGSRRGIVEADIDPHAVVGSAWIVLKQVSGAL
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHH
AAMTVVLCVLVYGAVAHALRPANEILVGIDRVAQGDLAWRLPSFRLRELRRIATVFNALA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
GHLQLATRERAELARRLIDAQEQERRWLSLELHDDVAQRLTALSLLARSIQDGARSAAPS
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSTESAELASMASDAVRALRITLASLRPPEIDDLGLRIALRSLIAAQAQRASGRIQVALR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ADAQVDRLPSEAAAHVYRIVQEGLTNAVRHAAARNVAIALNVVETDGGADVRLDFADDGS
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCC
GAPAEVLERPRPGLGLLGMRDRVHALGGQIVTETSPGGGFRLRVRFRAALAAREVS
CCCHHHHCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCEEEEEEEHHHHHHHCCC
>Mature Secondary Structure 
TTFSLKHVLAAWDARELDLKWALVGRIALIAILCAAGAAAYAMHDVAAKTRQRNAETAG
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
EVHKQLRLQLLRIERAADIPVRFPDWEIVTRYALQPGQCVQLIPAETGPTRSSCVGVEPH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
ALAAPDWFATLYRSLFFAGSTVRLPLEHQGSRRGIVEADIDPHAVVGSAWIVLKQVSGAL
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHH
AAMTVVLCVLVYGAVAHALRPANEILVGIDRVAQGDLAWRLPSFRLRELRRIATVFNALA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
GHLQLATRERAELARRLIDAQEQERRWLSLELHDDVAQRLTALSLLARSIQDGARSAAPS
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSTESAELASMASDAVRALRITLASLRPPEIDDLGLRIALRSLIAAQAQRASGRIQVALR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ADAQVDRLPSEAAAHVYRIVQEGLTNAVRHAAARNVAIALNVVETDGGADVRLDFADDGS
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCC
GAPAEVLERPRPGLGLLGMRDRVHALGGQIVTETSPGGGFRLRVRFRAALAAREVS
CCCHHHHCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCEEEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]