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The map label for this gene is uvrY [H]

Identifier: 170746767

GI number: 170746767

Start: 351448

End: 352113

Strand: Reverse

Name: uvrY [H]

Synonym: Mrad2831_0320

Alternate gene names: 170746767

Gene position: 352113-351448 (Counterclockwise)

Preceding gene: 170746768

Following gene: 170746761

Centisome position: 5.79

GC content: 66.07

Gene sequence:

>666_bases
ATGACCGGACGGCGCATACGGGTGATGCTCGTCGACGATCACGCCGTCGTACGGGAGGGATACCGGCGGCTCCTGGAACG
ACAGCCCGATATGGAGGTCGCCGCCGAAGCCCGGGACGGCGCGGAGGCCTACCGTACCTACCGGGCCGCGGAGCCGGACG
TCGTCATCATGGACATCAGCATGCCCGGCCGCGGCGGGATCGACGCCATCCGTCAGATTCGGCAGGTGGATCCGGACGCG
CGCATCCTCGTGTTCAGCGTGCATGCCGCCGTCAGCTACGCGCTCCAGGCCATACGCGCCGGCGCCCGCGGCTACATCAC
GAAGAGCAGCGCTTCGGAGCTCCTGATCGACGCCGTGCGCAGCGTGTTCAACAACAAGCTGACCCTGTGCGCCGAGATCT
CACACCTGCTGGCCGCGAGTCGGCTGGAGGAGCAGCCGTCCCCGATCGACCTCCTGTCGCCGCGGGAGTTCGAGATCCTG
CGGATGATCCTCGATGCGCGGCACACGGATGCGATCGCTGTCGATCTCAGCCTCTCGCCGAAGACCGTCGCGAACTACCA
CTACGCCATCAAATCGAAGCTCGGCGTCAGCTCGGACGTGGAACTCGTCTACTACTGCATCCGGTGCGGCCTGATCGATC
CGTTCTCCGTCGTCGGAGCGATCTAG

Upstream 100 bases:

>100_bases
TCCACGCGCTCGGCGGGCAGATCGTGACGGAAACGTCCCCGGGCGGCGGGTTTCGCCTGCGGGTCCGCTTTCGCGCCGCG
CTCGCGGCCAGGGAGGTGTC

Downstream 100 bases:

>100_bases
GTCTCGCGACCGCGCCGCTCCGGAACTCCACGCGGACGGCGCGCGGTGCCCTGCGGTGCAGAAGTCAGCACGGGCTGATC
GACTGCTCGCCGGCGGCGGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTGRRIRVMLVDDHAVVREGYRRLLERQPDMEVAAEARDGAEAYRTYRAAEPDVVIMDISMPGRGGIDAIRQIRQVDPDA
RILVFSVHAAVSYALQAIRAGARGYITKSSASELLIDAVRSVFNNKLTLCAEISHLLAASRLEEQPSPIDLLSPREFEIL
RMILDARHTDAIAVDLSLSPKTVANYHYAIKSKLGVSSDVELVYYCIRCGLIDPFSVVGAI

Sequences:

>Translated_221_residues
MTGRRIRVMLVDDHAVVREGYRRLLERQPDMEVAAEARDGAEAYRTYRAAEPDVVIMDISMPGRGGIDAIRQIRQVDPDA
RILVFSVHAAVSYALQAIRAGARGYITKSSASELLIDAVRSVFNNKLTLCAEISHLLAASRLEEQPSPIDLLSPREFEIL
RMILDARHTDAIAVDLSLSPKTVANYHYAIKSKLGVSSDVELVYYCIRCGLIDPFSVVGAI
>Mature_220_residues
TGRRIRVMLVDDHAVVREGYRRLLERQPDMEVAAEARDGAEAYRTYRAAEPDVVIMDISMPGRGGIDAIRQIRQVDPDAR
ILVFSVHAAVSYALQAIRAGARGYITKSSASELLIDAVRSVFNNKLTLCAEISHLLAASRLEEQPSPIDLLSPREFEILR
MILDARHTDAIAVDLSLSPKTVANYHYAIKSKLGVSSDVELVYYCIRCGLIDPFSVVGAI

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=39.5238095238095, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1790102, Length=197, Percent_Identity=36.0406091370558, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786747, Length=198, Percent_Identity=28.7878787878788, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788521, Length=196, Percent_Identity=32.6530612244898, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=26.6009852216749, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787473, Length=179, Percent_Identity=29.608938547486, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788546, Length=206, Percent_Identity=26.6990291262136, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082052, Length=103, Percent_Identity=31.0679611650485, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24455; Mature: 24323

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRRIRVMLVDDHAVVREGYRRLLERQPDMEVAAEARDGAEAYRTYRAAEPDVVIMDIS
CCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEEC
MPGRGGIDAIRQIRQVDPDARILVFSVHAAVSYALQAIRAGARGYITKSSASELLIDAVR
CCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHH
SVFNNKLTLCAEISHLLAASRLEEQPSPIDLLSPREFEILRMILDARHTDAIAVDLSLSP
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCC
KTVANYHYAIKSKLGVSSDVELVYYCIRCGLIDPFSVVGAI
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure 
TGRRIRVMLVDDHAVVREGYRRLLERQPDMEVAAEARDGAEAYRTYRAAEPDVVIMDIS
CCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEEC
MPGRGGIDAIRQIRQVDPDARILVFSVHAAVSYALQAIRAGARGYITKSSASELLIDAVR
CCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHH
SVFNNKLTLCAEISHLLAASRLEEQPSPIDLLSPREFEILRMILDARHTDAIAVDLSLSP
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCC
KTVANYHYAIKSKLGVSSDVELVYYCIRCGLIDPFSVVGAI
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]