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The map label for this gene is ppx [H]

Identifier: 170746592

GI number: 170746592

Start: 144903

End: 145985

Strand: Reverse

Name: ppx [H]

Synonym: Mrad2831_0142

Alternate gene names: 170746592

Gene position: 145985-144903 (Counterclockwise)

Preceding gene: 170746593

Following gene: 170746591

Centisome position: 2.4

GC content: 71.65

Gene sequence:

>1083_bases
ATGAGGGACGAGACCGCCGCGGCCGCGCCGTCCCGAATTCAGACCGGCGCGGTGCCGCTTCAGACGCAAGCTCCTATACC
GGGCCGTGAGCGTCGGCGCGCCGCCTACGCGGCGCTCGACCTGGGCACCAACAATTGCCGCCTGCTGGTCGCGGAGCCGA
CCTTCAGCGGCTTCCGCGTGATCGACGCGTTCTCGCGGATCGTGCGCCTCGGCGAGGGACTCGGCACGTCCGACCGCCTG
AGCGAGGCGGCGATCGAGCGGACCGTGGAGGCCCTGCGGATCTGCCGGGCCAAGATGCAGGCGCGCGGGGTGCAGCGGGC
CAAGATCATCGCCACGGAAGCCTGCCGCCTCGCGGTGAACGGCGCCGCCTTCGTAGAGCGCGTCCGCCGCGGCGTCGGCC
TCGACCTCGAGATCGTCGACCGGCAAACCGAGGCCTATCTCGCGGTCACCGGCTGCGCGGCGCTCGCGGATCCGCTCGCC
GAATCGGTCATCATCTTCGACATCGGCGGCGGCTCGACCGAGATCGCGTGGCTGGACGGGGCGGCCGCCAACCCGTCGAC
CGACCCGACTCTGCGGATTCGGGCCTGGGATTCTCTTCCGGTGGGCGTGGTGACGCTGGCCGAGCGCCACGGCGGCGCCG
AGGTCACCCGACGGATGTTCGAGGGCATGGTCGAGGAGGTGGCCGAGAAGCTCTCGGCCTTCGCGCTCCGGGCCGCCCCG
GCGGCGACGGCGCCGCACTTTCACCTGCTCGGAACGTCCGGCACCGTCACGACCATCGCGGCGATGCATCTGCGGCTCGC
CCGCTACGAGCGCCGGCGCGTCGACGGCTTGTGGATGAGCGACGACGCGGTCTCGACCGCCATCGACGACCTGCTCGACA
CGCGGCTCGAGCAGCGCGCCGACAACCCCTGTATCGGCCGCGACCGCGCCGATCTCGTGCTCGCGGGCTGCGCGATCCTC
GAGGCGATCCGCCGGGCCTTTCCCTCGGAGCGCCTGCGCATCGCCGATCGCGGCCTGCGCGAAGGATTGCTGATGAACAT
GATGCGGGAGGACGGGGTCTGGAACCGGAAGGCGGTCCGATGA

Upstream 100 bases:

>100_bases
GATGGGACATTGCAGTTCGCCGCCGAGCCTGTAGGGTCGCAGATCAGCGAAGGCCGAGCGCGCTGCTCAAGGCCGACCCG
AAGGATCGACGGCCGCGCCG

Downstream 100 bases:

>100_bases
GGGCGGCGCGATGAGCGACCGGCGCGGCGGCGCGAGTTCCGGCGGCGGTGTCCGGGGCGAACTGAAGCAGCGGGTGAAGA
CCGGCCGCGGACGGACCCTG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MRDETAAAAPSRIQTGAVPLQTQAPIPGRERRRAAYAALDLGTNNCRLLVAEPTFSGFRVIDAFSRIVRLGEGLGTSDRL
SEAAIERTVEALRICRAKMQARGVQRAKIIATEACRLAVNGAAFVERVRRGVGLDLEIVDRQTEAYLAVTGCAALADPLA
ESVIIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGAEVTRRMFEGMVEEVAEKLSAFALRAAP
AATAPHFHLLGTSGTVTTIAAMHLRLARYERRRVDGLWMSDDAVSTAIDDLLDTRLEQRADNPCIGRDRADLVLAGCAIL
EAIRRAFPSERLRIADRGLREGLLMNMMREDGVWNRKAVR

Sequences:

>Translated_360_residues
MRDETAAAAPSRIQTGAVPLQTQAPIPGRERRRAAYAALDLGTNNCRLLVAEPTFSGFRVIDAFSRIVRLGEGLGTSDRL
SEAAIERTVEALRICRAKMQARGVQRAKIIATEACRLAVNGAAFVERVRRGVGLDLEIVDRQTEAYLAVTGCAALADPLA
ESVIIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGAEVTRRMFEGMVEEVAEKLSAFALRAAP
AATAPHFHLLGTSGTVTTIAAMHLRLARYERRRVDGLWMSDDAVSTAIDDLLDTRLEQRADNPCIGRDRADLVLAGCAIL
EAIRRAFPSERLRIADRGLREGLLMNMMREDGVWNRKAVR
>Mature_360_residues
MRDETAAAAPSRIQTGAVPLQTQAPIPGRERRRAAYAALDLGTNNCRLLVAEPTFSGFRVIDAFSRIVRLGEGLGTSDRL
SEAAIERTVEALRICRAKMQARGVQRAKIIATEACRLAVNGAAFVERVRRGVGLDLEIVDRQTEAYLAVTGCAALADPLA
ESVIIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGAEVTRRMFEGMVEEVAEKLSAFALRAAP
AATAPHFHLLGTSGTVTTIAAMHLRLARYERRRVDGLWMSDDAVSTAIDDLLDTRLEQRADNPCIGRDRADLVLAGCAIL
EAIRRAFPSERLRIADRGLREGLLMNMMREDGVWNRKAVR

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=328, Percent_Identity=25.9146341463415, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI48994966, Length=320, Percent_Identity=28.125, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 39092; Mature: 39092

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDETAAAAPSRIQTGAVPLQTQAPIPGRERRRAAYAALDLGTNNCRLLVAEPTFSGFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCCCCCHHH
IDAFSRIVRLGEGLGTSDRLSEAAIERTVEALRICRAKMQARGVQRAKIIATEACRLAVN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEC
GAAFVERVRRGVGLDLEIVDRQTEAYLAVTGCAALADPLAESVIIFDIGGGSTEIAWLDG
HHHHHHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCEEEEEECCCCEEEEEECC
AAANPSTDPTLRIRAWDSLPVGVVTLAERHGGAEVTRRMFEGMVEEVAEKLSAFALRAAP
CCCCCCCCCEEEEEECCCCCCHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AATAPHFHLLGTSGTVTTIAAMHLRLARYERRRVDGLWMSDDAVSTAIDDLLDTRLEQRA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHC
DNPCIGRDRADLVLAGCAILEAIRRAFPSERLRIADRGLREGLLMNMMREDGVWNRKAVR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRDETAAAAPSRIQTGAVPLQTQAPIPGRERRRAAYAALDLGTNNCRLLVAEPTFSGFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCCCCCHHH
IDAFSRIVRLGEGLGTSDRLSEAAIERTVEALRICRAKMQARGVQRAKIIATEACRLAVN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEC
GAAFVERVRRGVGLDLEIVDRQTEAYLAVTGCAALADPLAESVIIFDIGGGSTEIAWLDG
HHHHHHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCEEEEEECCCCEEEEEECC
AAANPSTDPTLRIRAWDSLPVGVVTLAERHGGAEVTRRMFEGMVEEVAEKLSAFALRAAP
CCCCCCCCCEEEEEECCCCCCHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AATAPHFHLLGTSGTVTTIAAMHLRLARYERRRVDGLWMSDDAVSTAIDDLLDTRLEQRA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHC
DNPCIGRDRADLVLAGCAILEAIRRAFPSERLRIADRGLREGLLMNMMREDGVWNRKAVR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]