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The map label for this gene is rppH [H]

Identifier: 170746546

GI number: 170746546

Start: 101978

End: 102532

Strand: Reverse

Name: rppH [H]

Synonym: Mrad2831_0096

Alternate gene names: 170746546

Gene position: 102532-101978 (Counterclockwise)

Preceding gene: 170746547

Following gene: 170746545

Centisome position: 1.69

GC content: 69.73

Gene sequence:

>555_bases
ATGGTCGCCGCGATGGTAACGGATTCGGACCCAGGCACTGCCCTGCCCTATCGCCCCTGCGTGGGCATCGCCCTGATCGC
GCCGTCGGGCGGCGTCTTCGTCGGGCGTCGCAGCAAGGAGGCGGGTCCCGAGCACGTCGACGGTCCGCACATGTGGCAGA
TGCCGCAGGGCGGCATCGATCCCGGTGAGGATGCGGAAGCCGCCGCACGGCGCGAGCTCTACGAGGAGACCAACGTCCCG
CCGGAGGCGGTGAAGCTCCTCGCCGAGATCCCGGACTGGCTGCCCTACGACCTGCCCCCGGCGGTGATGAAGCAGGCCTG
GAAGGGCCGCTACCGTGGCCAGACGCAGAAATGGTTCGCCTACGGCTTCGTCGGCAGCGAGGACCTGATCGACGTGCTCC
GGCCCGGCGGCGGCGCTCACAAGGCGGAATTCGACGCTTGGCGCTGGGCGCAACTCTCCGAACTTCCGGACCTGATCGTC
CCCTTCAAGCGGCCGGTCTACGAGCGGGTCGTCGCGGCCTTCTCCGGCCTCGATCGCTGGGCGGCGCGGTCATGA

Upstream 100 bases:

>100_bases
GATTGAACGCGACCGTGTCGAAAGTCAGCGCAAGTAGATCCGGCACCGTCCGGATCGGTGAAGACTTGGTCGACGTTGCC
GCCTCGCCCACCCCTGACCT

Downstream 100 bases:

>100_bases
CCGCGCGGACGGGGCGCTGAGGCCGTGCGCTGGCTCGCGGTCCCGGTCGCCCTCGCCCTGGCGTGGCTCGCCTTCACGAT
GAGCCCGCTCTGGTCGCTCT

Product: NUDIX hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MVAAMVTDSDPGTALPYRPCVGIALIAPSGGVFVGRRSKEAGPEHVDGPHMWQMPQGGIDPGEDAEAAARRELYEETNVP
PEAVKLLAEIPDWLPYDLPPAVMKQAWKGRYRGQTQKWFAYGFVGSEDLIDVLRPGGGAHKAEFDAWRWAQLSELPDLIV
PFKRPVYERVVAAFSGLDRWAARS

Sequences:

>Translated_184_residues
MVAAMVTDSDPGTALPYRPCVGIALIAPSGGVFVGRRSKEAGPEHVDGPHMWQMPQGGIDPGEDAEAAARRELYEETNVP
PEAVKLLAEIPDWLPYDLPPAVMKQAWKGRYRGQTQKWFAYGFVGSEDLIDVLRPGGGAHKAEFDAWRWAQLSELPDLIV
PFKRPVYERVVAAFSGLDRWAARS
>Mature_184_residues
MVAAMVTDSDPGTALPYRPCVGIALIAPSGGVFVGRRSKEAGPEHVDGPHMWQMPQGGIDPGEDAEAAARRELYEETNVP
PEAVKLLAEIPDWLPYDLPPAVMKQAWKGRYRGQTQKWFAYGFVGSEDLIDVLRPGGGAHKAEFDAWRWAQLSELPDLIV
PFKRPVYERVVAAFSGLDRWAARS

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=38.5093167701863, Blast_Score=106, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20285; Mature: 20285

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAMVTDSDPGTALPYRPCVGIALIAPSGGVFVGRRSKEAGPEHVDGPHMWQMPQGGID
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCC
PGEDAEAAARRELYEETNVPPEAVKLLAEIPDWLPYDLPPAVMKQAWKGRYRGQTQKWFA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
YGFVGSEDLIDVLRPGGGAHKAEFDAWRWAQLSELPDLIVPFKRPVYERVVAAFSGLDRW
EECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHH
AARS
HCCC
>Mature Secondary Structure
MVAAMVTDSDPGTALPYRPCVGIALIAPSGGVFVGRRSKEAGPEHVDGPHMWQMPQGGID
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCC
PGEDAEAAARRELYEETNVPPEAVKLLAEIPDWLPYDLPPAVMKQAWKGRYRGQTQKWFA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
YGFVGSEDLIDVLRPGGGAHKAEFDAWRWAQLSELPDLIVPFKRPVYERVVAAFSGLDRW
EECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHH
AARS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA