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The map label for this gene is ctaD [H]

Identifier: 170746482

GI number: 170746482

Start: 33052

End: 34680

Strand: Reverse

Name: ctaD [H]

Synonym: Mrad2831_0032

Alternate gene names: 170746482

Gene position: 34680-33052 (Counterclockwise)

Preceding gene: 170746483

Following gene: 170746481

Centisome position: 0.57

GC content: 65.25

Gene sequence:

>1629_bases
ATGGCTACAGCCGCAGCCCATGCAGAGGCCCACGAGGTCCACGACCATAAGCCGTCGTTCTTCGCCCGCTGGTTCCTGTC
GACGAACCACAAGGACATCGGCACGCTCTACCTGCTCTTCGCCTTCTGCGCCGGCATGATCGGCGCGTTCCTCTCCTTCG
GCATCCGGATGGAGATGGAGGCGCCCGGCCTGCAGTACTTCTCGAATCCCGCGACCTACAACGTCTTCGTCACGGGCCAC
GGGCTCATCATGGTGTTCTTCATGGTGATGCCGGCGCTGATCGGCGGCTTCGGCAACTGGTTCGTGCCCCTCATGATCGG
CGCGCCCGACATGGCGTTCCCGCGCATGAACAACATCTCGTTCTGGCTCACGGTCGCGGGTTTCTGCTCGCTGCTCTGCT
CGCTGTTCGTCGAGGGCGCTCCCGGCGCGTCCGGCGCCGGCACCGGCTGGACCGTCTACCCGCCGCTCTCGACCGCCGGC
CATCCCGGCCCGGCCGTCGACTTCGCCATCTTCGCCCTGCACCTGTCGGGCGCGGGCTCGATCCTCGGCGCGATCAACTT
CATCACGACCATCCTGAACATGCGCGCCCCGGGCATGACGCTGCACAAGATGCCGCTCTTCGCCTGGGCCGAGCTGGTGA
CCGCGTTCCTCCTGCTGCTGTCGCTGCCGGTGCTCGCGGGCGCCATCACGATGCTGCTGACCGACCGCAATTTCGGAACG
ACCTTCTTCGATCCGGCCGGCGGCGGTGACCCGATCCTGTACCAGCACCTGTTCTGGTTCTTCGGTCACCCCGAAGTGTA
CATCATGATCCTGCCGGCCTTCGGCATCGTGTCGCACATCATCGCTACCTTCTCGCGCAAGCCGGTCTTCGGCTACCTCG
CGATGGCCTACGCCATGGTGGCGATCGGCGTGGTCGGCTTCGTCGTGTGGGCCCACCACATGTACACCGTCGGTCTGTCG
CTGCAGACGCAGTCCTACTTCGTGTTCGCCACGATGGTGATCGCCGTCCCGACCGGCGTGAAGATCTTCTCGTGGATCGC
CACCATGTGGGGCGGCTCCATCCGCTTCACCGCCGCGATGCACTGGGCGGTGGGCTTCATCTTCCTCTTCACGGTCGGCG
GCGTCACCGGCGTCGTGCTCGCCAACTCGGCGGTCGATAAGTACCTGCACGACACCTATTATGTGGTGGCGCACTTCCAC
TACGTCCTGTCTCTCGGCGCCGTGTTCATCATCTTCGCCGGTATCTACTACTGGTTCCCGAAGATGACCGGCCACATCAT
CCCGGAATGGGCCGGCAAGCTGCACTTCTGGCTGGCCTTCATCGGCGCGAACATCCTGTTCTTCCCGATGCACTTCCTCG
GACTGGCCGGCATGCCGCGCCGCTACGCCGACTACCCGGACGCCTTCGCCCAGTGGCACAAGGTGTCGACCTACGGCGGC
CACATCTTCGGTCTCGGCATGTTCGTGTTCGTGATCGGCGTGGTCCTGGCCTTCCGCTCGAAGGAGCGGGCCGCGGACAA
CCCGTGGGGTGAAGGCGCCACCACCCTCGAGTGGACGCTCTCCTCGCCGCCCCCGTTCCACCAGTTCGAGACGCTGCCCC
GCATCGTCGACGAGCCCGGCGCGCACTGA

Upstream 100 bases:

>100_bases
CCAAGTACGCCCGCATCGACACCGGCACGAGCGTCGCCGAGGCGCGCTGAGCCCCGGCTGACCGACCCGAACCCATCAGA
TCCACAAGGCATCCGAATCC

Downstream 100 bases:

>100_bases
TAGACACCCCGCGAGGGCCGCATCCGCGGCCCTCGCCCTTACCCGGAGGCCGGTCGGCCGACCTCCCGGCAAGGGCGAGC
GATGAGGGCGATCCGCACGG

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MATAAAHAEAHEVHDHKPSFFARWFLSTNHKDIGTLYLLFAFCAGMIGAFLSFGIRMEMEAPGLQYFSNPATYNVFVTGH
GLIMVFFMVMPALIGGFGNWFVPLMIGAPDMAFPRMNNISFWLTVAGFCSLLCSLFVEGAPGASGAGTGWTVYPPLSTAG
HPGPAVDFAIFALHLSGAGSILGAINFITTILNMRAPGMTLHKMPLFAWAELVTAFLLLLSLPVLAGAITMLLTDRNFGT
TFFDPAGGGDPILYQHLFWFFGHPEVYIMILPAFGIVSHIIATFSRKPVFGYLAMAYAMVAIGVVGFVVWAHHMYTVGLS
LQTQSYFVFATMVIAVPTGVKIFSWIATMWGGSIRFTAAMHWAVGFIFLFTVGGVTGVVLANSAVDKYLHDTYYVVAHFH
YVLSLGAVFIIFAGIYYWFPKMTGHIIPEWAGKLHFWLAFIGANILFFPMHFLGLAGMPRRYADYPDAFAQWHKVSTYGG
HIFGLGMFVFVIGVVLAFRSKERAADNPWGEGATTLEWTLSSPPPFHQFETLPRIVDEPGAH

Sequences:

>Translated_542_residues
MATAAAHAEAHEVHDHKPSFFARWFLSTNHKDIGTLYLLFAFCAGMIGAFLSFGIRMEMEAPGLQYFSNPATYNVFVTGH
GLIMVFFMVMPALIGGFGNWFVPLMIGAPDMAFPRMNNISFWLTVAGFCSLLCSLFVEGAPGASGAGTGWTVYPPLSTAG
HPGPAVDFAIFALHLSGAGSILGAINFITTILNMRAPGMTLHKMPLFAWAELVTAFLLLLSLPVLAGAITMLLTDRNFGT
TFFDPAGGGDPILYQHLFWFFGHPEVYIMILPAFGIVSHIIATFSRKPVFGYLAMAYAMVAIGVVGFVVWAHHMYTVGLS
LQTQSYFVFATMVIAVPTGVKIFSWIATMWGGSIRFTAAMHWAVGFIFLFTVGGVTGVVLANSAVDKYLHDTYYVVAHFH
YVLSLGAVFIIFAGIYYWFPKMTGHIIPEWAGKLHFWLAFIGANILFFPMHFLGLAGMPRRYADYPDAFAQWHKVSTYGG
HIFGLGMFVFVIGVVLAFRSKERAADNPWGEGATTLEWTLSSPPPFHQFETLPRIVDEPGAH
>Mature_541_residues
ATAAAHAEAHEVHDHKPSFFARWFLSTNHKDIGTLYLLFAFCAGMIGAFLSFGIRMEMEAPGLQYFSNPATYNVFVTGHG
LIMVFFMVMPALIGGFGNWFVPLMIGAPDMAFPRMNNISFWLTVAGFCSLLCSLFVEGAPGASGAGTGWTVYPPLSTAGH
PGPAVDFAIFALHLSGAGSILGAINFITTILNMRAPGMTLHKMPLFAWAELVTAFLLLLSLPVLAGAITMLLTDRNFGTT
FFDPAGGGDPILYQHLFWFFGHPEVYIMILPAFGIVSHIIATFSRKPVFGYLAMAYAMVAIGVVGFVVWAHHMYTVGLSL
QTQSYFVFATMVIAVPTGVKIFSWIATMWGGSIRFTAAMHWAVGFIFLFTVGGVTGVVLANSAVDKYLHDTYYVVAHFHY
VLSLGAVFIIFAGIYYWFPKMTGHIIPEWAGKLHFWLAFIGANILFFPMHFLGLAGMPRRYADYPDAFAQWHKVSTYGGH
IFGLGMFVFVIGVVLAFRSKERAADNPWGEGATTLEWTLSSPPPFHQFETLPRIVDEPGAH

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=513, Percent_Identity=60.233918128655, Blast_Score=585, Evalue=1e-167,
Organism=Escherichia coli, GI1786634, Length=528, Percent_Identity=43.1818181818182, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6226519, Length=531, Percent_Identity=56.6854990583804, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=62.3853211009174, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6226523, Length=256, Percent_Identity=57.421875, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6226522, Length=79, Percent_Identity=46.8354430379747, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6226521, Length=66, Percent_Identity=46.969696969697, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59498; Mature: 59367

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAAAHAEAHEVHDHKPSFFARWFLSTNHKDIGTLYLLFAFCAGMIGAFLSFGIRMEME
CCCCHHCHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
APGLQYFSNPATYNVFVTGHGLIMVFFMVMPALIGGFGNWFVPLMIGAPDMAFPRMNNIS
CCCCHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEHEECCCCCCCCCCCCCH
FWLTVAGFCSLLCSLFVEGAPGASGAGTGWTVYPPLSTAGHPGPAVDFAIFALHLSGAGS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCHH
ILGAINFITTILNMRAPGMTLHKMPLFAWAELVTAFLLLLSLPVLAGAITMLLTDRNFGT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
TFFDPAGGGDPILYQHLFWFFGHPEVYIMILPAFGIVSHIIATFSRKPVFGYLAMAYAMV
CEECCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AIGVVGFVVWAHHMYTVGLSLQTQSYFVFATMVIAVPTGVKIFSWIATMWGGSIRFTAAM
HHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHH
HWAVGFIFLFTVGGVTGVVLANSAVDKYLHDTYYVVAHFHYVLSLGAVFIIFAGIYYWFP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMTGHIIPEWAGKLHFWLAFIGANILFFPMHFLGLAGMPRRYADYPDAFAQWHKVSTYGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHCCCCC
HIFGLGMFVFVIGVVLAFRSKERAADNPWGEGATTLEWTLSSPPPFHQFETLPRIVDEPG
HHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
AH
CC
>Mature Secondary Structure 
ATAAAHAEAHEVHDHKPSFFARWFLSTNHKDIGTLYLLFAFCAGMIGAFLSFGIRMEME
CCCHHCHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
APGLQYFSNPATYNVFVTGHGLIMVFFMVMPALIGGFGNWFVPLMIGAPDMAFPRMNNIS
CCCCHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEHEECCCCCCCCCCCCCH
FWLTVAGFCSLLCSLFVEGAPGASGAGTGWTVYPPLSTAGHPGPAVDFAIFALHLSGAGS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCHH
ILGAINFITTILNMRAPGMTLHKMPLFAWAELVTAFLLLLSLPVLAGAITMLLTDRNFGT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
TFFDPAGGGDPILYQHLFWFFGHPEVYIMILPAFGIVSHIIATFSRKPVFGYLAMAYAMV
CEECCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AIGVVGFVVWAHHMYTVGLSLQTQSYFVFATMVIAVPTGVKIFSWIATMWGGSIRFTAAM
HHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHH
HWAVGFIFLFTVGGVTGVVLANSAVDKYLHDTYYVVAHFHYVLSLGAVFIIFAGIYYWFP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMTGHIIPEWAGKLHFWLAFIGANILFFPMHFLGLAGMPRRYADYPDAFAQWHKVSTYGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHCCCCC
HIFGLGMFVFVIGVVLAFRSKERAADNPWGEGATTLEWTLSSPPPFHQFETLPRIVDEPG
HHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
AH
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]