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The map label for this gene is ctaB

Identifier: 170746481

GI number: 170746481

Start: 31886

End: 32836

Strand: Reverse

Name: ctaB

Synonym: Mrad2831_0031

Alternate gene names: 170746481

Gene position: 32836-31886 (Counterclockwise)

Preceding gene: 170746482

Following gene: 170746480

Centisome position: 0.54

GC content: 70.03

Gene sequence:

>951_bases
ATGACGAGCCTGACGAACACGATCGGACCGGACGTTCCGGGTCCGGCCCTCACGACCGCCGGCGGCGACGTTCCGGACTA
CTTCGCCCTGCTGAAGCCCCGGGTGATGGTCCTCGTCATCTTCACCGCGCTGGTCGGCATGGTGGTCTCGCAGGGCCACG
TGCAGCCGGCCATCGGCGCGATCTCGCTCCTCGCCATCGCGGTCGGAGCCGGGGCGTCCGGCTGCCTGAACATGTGGTGG
GACGCCGACATCGATGCGGTCATGAGCCGGACCGCCACCCGGCCGATCCCGTCGGGCCGGATCACCTCGGAGGAGGCGCT
GGGCTTCGGGCTGTTCCTGTCGGTCGCCTCGGTGGTCGTGCTCGGGCTCGCCGCCAATCTCCTGGCCGCCGCGCTCCTCG
CCTTCACCATCGTGTTCTACGCGGTGGTGTACTCGATGTGGCTGAAGCGGGCGACCGCTCAGAATATCGTCATCGGCGGC
GCCGCGGGCGCCCTGCCGCCGGTCATCGGCCAGGCGGTGGTGACCGGGTCGATCGGCATCGAGTCGCTGATCCTGTTCGC
CATCATCTTCATCTGGACCCCGCCGCACTTCTGGGCGCTCGCCCTGATCAAGGCCGACGAGTACGCCCGCGCCGGCATCC
CGATGATGCCCAACGTGGCCGGCCCGGCCTCCACCCGCCGCCAGATCGTGTGGTACTCGCTGCTCCTCGCGCCGCTCGGC
CTCGTCCCGGTGGCGCTGGGCTTCGGCGGGCTCGTCTACGCTGTGGTCGGCCTGGTGGGCGGCCTCGGCATGGTGGCCTT
CAGCATCCGGGTGCTTCGGAACCCGGAGGGCGATGCCGAGCGGCGCGCCGCCATGGGCATGTTCGGCTTCTCGATCCTCT
ACCTGTTCGCGCTGTTCTCGGCGCTCCTGGCCGAGCAGAGCTTCGGCCTGTTCCGCCCGGTCCTGGGTTGA

Upstream 100 bases:

>100_bases
CTGGGCCCCGCTCACGCCGATCCTTGGAACACGTCGAATTCGAGACACGACTCGGCCGTGACGCGCGCGGCCGGGCGCCG
ACACAGCAGCGGCAGACGCG

Downstream 100 bases:

>100_bases
GCGCCATGGCGGATCCCGAGATCCAGTACCGGCCGCTCACGCCCGAGCAGGAGGCGCGGCGCCGCAAGCGGTCGATCGCG
ATCGCGCTGGCCCTCGGTGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTSLTNTIGPDVPGPALTTAGGDVPDYFALLKPRVMVLVIFTALVGMVVSQGHVQPAIGAISLLAIAVGAGASGCLNMWW
DADIDAVMSRTATRPIPSGRITSEEALGFGLFLSVASVVVLGLAANLLAAALLAFTIVFYAVVYSMWLKRATAQNIVIGG
AAGALPPVIGQAVVTGSIGIESLILFAIIFIWTPPHFWALALIKADEYARAGIPMMPNVAGPASTRRQIVWYSLLLAPLG
LVPVALGFGGLVYAVVGLVGGLGMVAFSIRVLRNPEGDAERRAAMGMFGFSILYLFALFSALLAEQSFGLFRPVLG

Sequences:

>Translated_316_residues
MTSLTNTIGPDVPGPALTTAGGDVPDYFALLKPRVMVLVIFTALVGMVVSQGHVQPAIGAISLLAIAVGAGASGCLNMWW
DADIDAVMSRTATRPIPSGRITSEEALGFGLFLSVASVVVLGLAANLLAAALLAFTIVFYAVVYSMWLKRATAQNIVIGG
AAGALPPVIGQAVVTGSIGIESLILFAIIFIWTPPHFWALALIKADEYARAGIPMMPNVAGPASTRRQIVWYSLLLAPLG
LVPVALGFGGLVYAVVGLVGGLGMVAFSIRVLRNPEGDAERRAAMGMFGFSILYLFALFSALLAEQSFGLFRPVLG
>Mature_315_residues
TSLTNTIGPDVPGPALTTAGGDVPDYFALLKPRVMVLVIFTALVGMVVSQGHVQPAIGAISLLAIAVGAGASGCLNMWWD
ADIDAVMSRTATRPIPSGRITSEEALGFGLFLSVASVVVLGLAANLLAAALLAFTIVFYAVVYSMWLKRATAQNIVIGGA
AGALPPVIGQAVVTGSIGIESLILFAIIFIWTPPHFWALALIKADEYARAGIPMMPNVAGPASTRRQIVWYSLLLAPLGL
VPVALGFGGLVYAVVGLVGGLGMVAFSIRVLRNPEGDAERRAAMGMFGFSILYLFALFSALLAEQSFGLFRPVLG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=210, Percent_Identity=32.8571428571429, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=32.258064516129, Blast_Score=114, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=265, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=218, Percent_Identity=29.8165137614679, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921064, Length=300, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_METRJ (B1M595)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001752741.1
- GeneID:   6136330
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_0031
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32902; Mature: 32770

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12787c8c)-; HASH(0x150fa048)-; HASH(0x150efe9c)-; HASH(0x150e5cf4)-; HASH(0x150f81ec)-; HASH(0x150edc2c)-; HASH(0x150f5f60)-; HASH(0x150f5ed0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLTNTIGPDVPGPALTTAGGDVPDYFALLKPRVMVLVIFTALVGMVVSQGHVQPAIGA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ISLLAIAVGAGASGCLNMWWDADIDAVMSRTATRPIPSGRITSEEALGFGLFLSVASVVV
HHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGLAANLLAAALLAFTIVFYAVVYSMWLKRATAQNIVIGGAAGALPPVIGQAVVTGSIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCCH
ESLILFAIIFIWTPPHFWALALIKADEYARAGIPMMPNVAGPASTRRQIVWYSLLLAPLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LVPVALGFGGLVYAVVGLVGGLGMVAFSIRVLRNPEGDAERRAAMGMFGFSILYLFALFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAEQSFGLFRPVLG
HHHHHHHCCHHHCCCH
>Mature Secondary Structure 
TSLTNTIGPDVPGPALTTAGGDVPDYFALLKPRVMVLVIFTALVGMVVSQGHVQPAIGA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ISLLAIAVGAGASGCLNMWWDADIDAVMSRTATRPIPSGRITSEEALGFGLFLSVASVVV
HHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGLAANLLAAALLAFTIVFYAVVYSMWLKRATAQNIVIGGAAGALPPVIGQAVVTGSIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCCH
ESLILFAIIFIWTPPHFWALALIKADEYARAGIPMMPNVAGPASTRRQIVWYSLLLAPLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LVPVALGFGGLVYAVVGLVGGLGMVAFSIRVLRNPEGDAERRAAMGMFGFSILYLFALFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAEQSFGLFRPVLG
HHHHHHHCCHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA