Click here to switch to the map view.

The map label for this gene is adk

Identifier: 170762193

GI number: 170762193

Start: 287104

End: 287745

Strand: Direct

Name: adk

Synonym: UPA3_0259

Alternate gene names: 170762193

Gene position: 287104-287745 (Clockwise)

Preceding gene: 170762149

Following gene: 170762236

Centisome position: 38.2

GC content: 28.5

Gene sequence:

>642_bases
ATGAAAATCCTTTTAATTGGCCCCCCAGGGAGTGGTAAGGGAAGTGTTAGTGAATTATTAACTAAAAATAATACATTAAA
ACATGTTTCCACAGGTAATTTATTTCGTGCAATTCTAAAAGAGGATAGCGAATTAGCACGTAAAATTAAAGAGATTAATG
TTTCTGGTGGTAAATTAGTACCAGATGAAATTACTAATCAAGTTGCTAAATCAGCAATTGATGAATTAATTAAAAATGAA
CAATCATTTATTTTAGATGGTTATCCACGCACAATTAATCAAGCCTTAGCATTAGAACAATATTGTAATTTAGATTATAT
TTTTTATCTAGATATTGATCATCAAGAATTAATGAAACGTTTAACTGGGCGTTGAATGTGCCCAAAATGTGCAGGAATTT
ATAATATTCATTTTAAAAAACCACAAGTTCATGGTTTATGTGACAATGATCAAGCTACTCTTTATCAACGAGCTGATGAT
CATGCAGATGCTGTAAGTATTCGATTAGATGAATATGATAAATTAACCCTACCTTTGATTAAGCATTATGAAACTAATCC
ACGTTTTATTAAAATCAATGCTAATCAACCTATTGAAGATGTTTATAAAAACATTAACAATTATTTAAAACAAAATAAGT
AA

Upstream 100 bases:

>100_bases
CAACATCATACGCTTACCAAAGAAAAGAATTAGAAACATCCATTACAGTAAGCGCTGAAAGTGACAAGAGTAGTAAGTCA
CAAATTTGATAGAGGTATTT

Downstream 100 bases:

>100_bases
AAAAAAGTAGATGAAGTTAAAACCATGGTTATTGTTAAAACAGAAAAAGATATTGCTGCTATTAAAGAAGCTGTGCGAAT
TTGAAAAATTGCTCGTGAAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLVPDEITNQVAKSAIDELIKNE
QSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKRLTGRWMCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADD
HADAVSIRLDEYDKLTLPLIKHYETNPRFIKINANQPIEDVYKNINNYLKQNK

Sequences:

>Translated_213_residues
MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLVPDEITNQVAKSAIDELIKNE
QSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKRLTGR*MCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADD
HADAVSIRLDEYDKLTLPLIKHYETNPRFIKINANQPIEDVYKNINNYLKQNK
>Mature_213_residues
MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLVPDEITNQVAKSAIDELIKNE
QSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKRLTGR*MCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADD
HADAVSIRLDEYDKLTLPLIKHYETNPRFIKINANQPIEDVYKNINNYLKQNK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI310110345, Length=185, Percent_Identity=34.0540540540541, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI53832003, Length=185, Percent_Identity=34.0540540540541, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI8051579, Length=185, Percent_Identity=34.0540540540541, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI53832001, Length=185, Percent_Identity=34.0540540540541, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=34.2391304347826, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=34.1232227488152, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=34.1232227488152, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=27.0531400966184, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144897, Length=207, Percent_Identity=29.951690821256, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=207, Percent_Identity=29.951690821256, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI237858799, Length=124, Percent_Identity=33.0645161290323, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI22749187, Length=172, Percent_Identity=26.7441860465116, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=34.7222222222222, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=31.3084112149533, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=201, Percent_Identity=28.3582089552239, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=23.8317757009346, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=203, Percent_Identity=25.1231527093596, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=220, Percent_Identity=34.5454545454545, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=26.8867924528302, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=31.6326530612245, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=39.6739130434783, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=39.6739130434783, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=33.0232558139535, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24663208, Length=200, Percent_Identity=24, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647141, Length=200, Percent_Identity=24, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24127; Mature: 24127

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLV
CEEEEECCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEC
PDEITNQVAKSAIDELIKNEQSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKR
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
LTGRMCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADDHADAVSIRLDEYDKLTLPLIK
HHHHCCHHHCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
HYETNPRFIKINANQPIEDVYKNINNYLKQNK
HCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLV
CEEEEECCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEC
PDEITNQVAKSAIDELIKNEQSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKR
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
LTGRMCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADDHADAVSIRLDEYDKLTLPLIK
HHHHCCHHHCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
HYETNPRFIKINANQPIEDVYKNINNYLKQNK
HCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA