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The map label for this gene is fhs

Identifier: 170762049

GI number: 170762049

Start: 265358

End: 266923

Strand: Direct

Name: fhs

Synonym: UPA3_0228

Alternate gene names: 170762049

Gene position: 265358-266923 (Clockwise)

Preceding gene: 170761980

Following gene: 170762132

Centisome position: 35.3

GC content: 27.39

Gene sequence:

>1566_bases
ATGGCAAAAATTATTGAAGAAATGATTAATAAAAAAGGGTTGTTAATTGATGATTATGAACTTTATGGCAATGAGATTGC
TAAAATTAAATCAATTAAAAAACTAAATAAAAAGGATTCAAAATTAATTGTTATTACCTCAATGAATCCTAATCCAGCTG
GTGAAGGTAAAACAACAACTGCTATTGGTTTAGTTGATGCTTTAAATAAACATGGATACAAAGCAATTGGAGCCTTACGA
GAGCCATCAATGGGACCAGTTTTTGGTATGAAAGGTACGGGTTCTGGAGGAGGATTATCTTTTTTAAAACCCTTTGATAA
AATTAATTTACATTTTAGTGGTGATTTCCATGCGATTACTGCAGCTAATAATTTAATCGTTGCAGTAATAGAAAATGAAA
TACATAATAGGTCTTCAATGCAAATCGATTCTCAAAAAATTTTAATTAAAAGATGTCTAGATGTTAATGATCGTTCTTTA
CGTAATATTGAATATGATATTAACCATCAACAAACAAAAAGTGGTTTCAACATTACAGCAGCGAGTGATTTAATGGCATT
ATTTTGTTTAGCACATGATCATAAAGATTTTGAAGATAAACTTGCGCAAACAATTGTTGCATATAATATAGTAAACCAAC
CTATAAGAATTTGTGATTTAGAATTAACAAAAGCTATTATGGCAATTTTAGAAGATGCTTTATATGCTAATTTAGTACGA
ACTAATGAGGATAACCCTGTTTTTGTTCATGGTGGCCCATTTGCTAATATTGCTCATGGTTGTAATAGTATTATTGCAAC
CAAAAATGCTTTAGCTTTAGGTGATTATGTTGTTACTGAATGTGGTTTTGGTAGCGATTTAGGACTTGAAAAATTTATGA
ATATCAAGATGGCTAGTTTGAATTTAAAACCAGATTTAATTGGTTTAGTTATTAGTCTAAAATCAATCGCATATCATGCT
CAAACAAACGAAAAAGACTACGTTAAACAAGGCTTTGCTAATGTTTTATGTCATATTAATCACATTAAAAAATATAATGT
TTCTTTTATTGTTTATATTAATGTCAATACTAATACTGATAGCGAAGAAGACTTATTAACTTTAGAAAAACTATTAGATG
AACATCAAATTGAACATGCACGTTCTTATGCTTATAGCTATGGTTCTAAAAAAAGTGAAGAAATAACTAAAAAAACAATT
ACTTTAACTAATCAAATTAATGATCATGAATTAAAATTAATTTATGATATTAAAGATCATTTATCATATAAATTAAAAAA
AATATGTGAAAATGTTTATGGTGCTGATGGATATGAATTAAGCTATGAAGCTAAAGAACAATTGAATCGTTATGAACATT
TAGATTTTTATTTATGCATTGCTAAAACACCATATTCAATTTCTGATGATGCAAAATTATTAAATAATCCTAAGAACTTT
AAAATTCATATTGAACGCTTTGAAATTAATTATGCTGCAAAATTAATCATTGCTATTACAACAACTATTTATCGTATGCC
TGGCTTAAATAAAGAACCAGCGGCCAAAAATTTCGTTATGAAATAA

Upstream 100 bases:

>100_bases
TATTTTTAGTGTTAACTGTTATTTTAGGTTTAATTTTTTATTTGATGTATACTATTTTAAAAAGAAAATACACTATCAAA
AAATAAAAGAAGGTTTATAT

Downstream 100 bases:

>100_bases
CTATTAAAAATCTTTATTATTAAAAAAATAAAAAATAAACAAGTTGATCGCTTCAAAGATGCTTGTTTATTTTTTTCATA
CTTTAGAAGATAAAAAAATA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MAKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTTAIGLVDALNKHGYKAIGALR
EPSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAITAANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSL
RNIEYDINHQQTKSGFNITAASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVR
TNEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASLNLKPDLIGLVISLKSIAYHA
QTNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTDSEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTI
TLTNQINDHELKLIYDIKDHLSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNF
KIHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK

Sequences:

>Translated_521_residues
MAKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTTAIGLVDALNKHGYKAIGALR
EPSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAITAANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSL
RNIEYDINHQQTKSGFNITAASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVR
TNEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASLNLKPDLIGLVISLKSIAYHA
QTNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTDSEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTI
TLTNQINDHELKLIYDIKDHLSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNF
KIHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK
>Mature_520_residues
AKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTTAIGLVDALNKHGYKAIGALRE
PSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAITAANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSLR
NIEYDINHQQTKSGFNITAASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVRT
NEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASLNLKPDLIGLVISLKSIAYHAQ
TNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTDSEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTIT
LTNQINDHELKLIYDIKDHLSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNFK
IHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=596, Percent_Identity=32.5503355704698, Blast_Score=285, Evalue=1e-76,
Organism=Homo sapiens, GI36796743, Length=594, Percent_Identity=31.6498316498317, Blast_Score=270, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17568737, Length=599, Percent_Identity=32.0534223706177, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17568739, Length=599, Percent_Identity=32.0534223706177, Blast_Score=267, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321643, Length=597, Percent_Identity=32.6633165829146, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6319558, Length=604, Percent_Identity=29.8013245033113, Blast_Score=249, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24645718, Length=585, Percent_Identity=32.6495726495726, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI17137370, Length=585, Percent_Identity=32.6495726495726, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI62472483, Length=585, Percent_Identity=32.6495726495726, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45551871, Length=585, Percent_Identity=32.6495726495726, Blast_Score=292, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_UREPA (Q9PQS1)

Other databases:

- EMBL:   AF222894
- RefSeq:   NP_078054.1
- ProteinModelPortal:   Q9PQS1
- GeneID:   876396
- GenomeReviews:   AF222894_GR
- KEGG:   uur:UU221
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   CLSK2298835
- BioCyc:   UURE95667:UU221-MONOMER
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58467; Mature: 58336

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTT
CHHHHHHHHCCCCCEEECHHHHCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCH
AIGLVDALNKHGYKAIGALREPSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAIT
HHHHHHHHHHCCCHHHHCCCCCCCCCEECCCCCCCCCCCHHHCCCCCEEEEECCCEEEEE
AANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSLRNIEYDINHQQTKSGFNITA
ECCCEEEEEEECCCCCCCCCEECHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEH
ASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHE
TNEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASL
ECCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCHHEECCCCCCCCCHHHHHCEEEEEE
NLKPDLIGLVISLKSIAYHAQTNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTD
CCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCCC
SEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTITLTNQINDHELKLIYDIKDH
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCCCCCEEEEEEECHHH
LSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNF
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHCCCCCE
KIHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK
EEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTT
HHHHHHHHCCCCCEEECHHHHCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCH
AIGLVDALNKHGYKAIGALREPSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAIT
HHHHHHHHHHCCCHHHHCCCCCCCCCEECCCCCCCCCCCHHHCCCCCEEEEECCCEEEEE
AANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSLRNIEYDINHQQTKSGFNITA
ECCCEEEEEEECCCCCCCCCEECHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEH
ASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHE
TNEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASL
ECCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCHHEECCCCCCCCCHHHHHCEEEEEE
NLKPDLIGLVISLKSIAYHAQTNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTD
CCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCCC
SEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTITLTNQINDHELKLIYDIKDH
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCCCCCEEEEEEECHHH
LSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNF
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHCCCCCE
KIHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK
EEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11048724