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The map label for this gene is upp

Identifier: 170762026

GI number: 170762026

Start: 151752

End: 152375

Strand: Reverse

Name: upp

Synonym: UPA3_0122

Alternate gene names: 170762026

Gene position: 152375-151752 (Counterclockwise)

Preceding gene: 170761932

Following gene: 170762302

Centisome position: 20.27

GC content: 29.01

Gene sequence:

>624_bases
ATGCATAAAATAATTAATCACCCATTAATTAAAGATAAACTAACACGTATGCGAAAAGTTTCAACAGTTTCTACTGTTTT
TCGTACAAATTTAGAAGAACTTACACAATTGATGGTTTATGAAGCAACAAAAGATTTAGAGTTAAATGAAATAGAAATTG
AAACTCCTGTTGTTAAGGTTGCAAAAGGTTATAAATTAAAAAATAAAATTTGTTTAATACCTATTTTGCGCGCTGGAATT
GGAATGGTTGATGGTGTTAAAAGTTTAATTCCAACAGCCACAATCGGTCATATCGGTTTATATCGTAATGAACAAACACT
AAAACCAGTAGAATATTTTAAAAAATTTCCTAAAAATATTTCTGAATCAGATGTTATTATTTTAGATCCAATGTTAGCAA
CAGGAGGTAGTGTTGTTGAAGCTGTTAATATTATTAAAAAATACAATCCAAAATCCATTAAATTTGTATGTATTGTTGCA
GCTCCAGAAGGTCTTAAATATGTTCAAGAAGTTCATCCTGAAGTTGATGTTTATATCGCAGCATTAGATGATAAATTAAA
TGAAAATGGATATATCACTCCTGGTTTAGGTGATGCTGGTGATCGAATTTTCGGTACTAAATAA

Upstream 100 bases:

>100_bases
GTTTTTTTCATTTTATTAAGTTATTTATAATAATAAATTTTATAATTAAGAACGAATATTAAAATTATATATACAAGTTA
AATGATTTAAGGAGTTAAAA

Downstream 100 bases:

>100_bases
TTTTAATAATTAAGTAAAGAATAAAAAAAGCAATTCATAATAGAATTGCTTTTTTATTTATTAATGGAGCAGATGACGAG
AATCGAACTCGCGTCTCGAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKVAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLKYVQEVHPEVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK

Sequences:

>Translated_207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKVAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLKYVQEVHPEVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK
>Mature_207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKVAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLKYVQEVHPEVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=28.921568627451, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=28.921568627451, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.0588235294118, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=49.2610837438424, Blast_Score=203, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17539892, Length=195, Percent_Identity=27.1794871794872, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17539894, Length=195, Percent_Identity=27.1794871794872, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=35.4166666666667, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45550449, Length=210, Percent_Identity=29.0476190476191, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573516, Length=210, Percent_Identity=29.0476190476191, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573514, Length=210, Percent_Identity=29.0476190476191, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573512, Length=210, Percent_Identity=29.0476190476191, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358379, Length=151, Percent_Identity=25.8278145695364, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_UREP2 (B1AIA5)

Other databases:

- EMBL:   CP000942
- RefSeq:   YP_001752199.1
- ProteinModelPortal:   B1AIA5
- SMR:   B1AIA5
- GeneID:   6155393
- GenomeReviews:   CP000942_GR
- KEGG:   upa:UPA3_0122
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   UPAR505682:UPA3_0122-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23035; Mature: 23035

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 192-192 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHH
AKGYKLKNKICLIPILRAGIGMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNI
HCCCEECCCEEEEEHHHHCCCHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHHHCCCC
SESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVAAPEGLKYVQEVHPEVDVYIA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCEEEEE
ALDDKLNENGYITPGLGDAGDRIFGTK
EECCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHH
AKGYKLKNKICLIPILRAGIGMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNI
HCCCEECCCEEEEEHHHHCCCHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHHHCCCC
SESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVAAPEGLKYVQEVHPEVDVYIA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCEEEEE
ALDDKLNENGYITPGLGDAGDRIFGTK
EECCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA