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The map label for this gene is eefC [H]

Identifier: 170681888

GI number: 170681888

Start: 1855128

End: 1856501

Strand: Reverse

Name: eefC [H]

Synonym: EcSMS35_1834

Alternate gene names: 170681888

Gene position: 1856501-1855128 (Counterclockwise)

Preceding gene: 170683789

Following gene: 170680921

Centisome position: 36.63

GC content: 53.78

Gene sequence:

>1374_bases
ATGTTGCGTCGTTCTCTTATTTTTCTGGTGTTGTTGAGTGCGGGATGTGTCTCGCTCGATCCTCACTACAGTACGCCTGA
ATCCCCAATCCCGGCGACCTTGCCGGGAGCACAGGGCCAGGGGAAGGCAATCAGCCATGACTGGCAGCAGGTGATTCACG
ATCCCCGATTGCAGCAGGTAGTAACCATTGCACTGAACAGTAACCGCGATGTGCAAAAAGCGATTGCTGATATTGACTCA
GCACGGGCGCTCTATGGGCAAACTAATGCGTCGTTATTTCCGACGGTGAATGCGGCCTTAAGTTCGACTCGCAGTCGTTC
GCTGGCGAATGGTACGGGAACAACTGCCGAGGCTGACGGCACGGTGTCCAGTTATACGTTAGATCTGTTTGGTCGTAATC
AGAGTTTATCTCGGGCGGCGCGGGAAACCTGGCTTGCCAGTGAATTTACAGCCCAGAACACTCGTTTAACGCTGATTGCT
GAAATCAGCACCGCCTGGCTGACACTGGCGGCTGATAACAGCAACCTGGCCCTGGCAAAAGAAACGATGGCCAGTGCAGA
AAACTCATTGAAAATTATCCAGCGCCAGCAACAGGTTGGCACGGCGGCAGCGACAGATGTCAGTGAGGCGATGAGTGTTT
ATCAGCAAGCGCGCGCCAGCGTTGCCAGCTATCAGACACAAGTGATGCAGGATAAAAATGCGCTGAACTTACTGGCAGGT
ACAACGCTTGCGGAAAATCTGCTACCGGGAACACTGGAAAGCCTGCCGGAACAAATGATAAGTCTGGTTCCTGCGGGAGT
ATCATCTGATGTTCTGCTGCGTCGCCCGGATATCCAGGAAGCGGAACATAATTTGAAGAGCGCCAATGCCGATATTGGCG
CGGCACGGGCTAACTTTTTCCCGACGATTTCGCTGACTGCCAGTGCCGGTGTTGGCAGTGACGCGTTGTCGTCGTTGTTC
AGCCACGGAATGCAGATCTGGTCATTTGCGCCATCGGTCACATTACCGCTGTTTACTGGCGGAAGTAATCTGGCGCAGCT
TCGTTACGCAGAAGCACAAAAGCGTGGACTCATTGCCACCTATGAAAAAACCGTTCAGAGCGCATTTAAAGATGTCGCTA
ACGCACTGGCGCGGCGGACCACGCTTGAAGAGCAACTGGATGCACAGCGCCAGTATGTTAAAGCTGAACAACAAACGGTC
GATGTTGGCTTGCGTCGCTATCAGGCGGGTGTTGGTGATTACCTGACCGTGTTGACGGCGCAGCGCAGCTTGTGGAGCGC
ACAGCAGGAGCTGCTGGCACTGCAACTGACTGATTTTACAAACCGAATCACGCTCTGGCAGTCGCTGGGCGGCGGCATGT
CATCACTCAAGTAA

Upstream 100 bases:

>100_bases
CACGCTGACCGCTACATTACTGGCCATTTTCTTCGTTCCTCTGTTTTTTGTACTGGTGAAACGTTTGTTTGCCGGTAAAC
CGCGCCGTCAGGAGTAAGTT

Downstream 100 bases:

>100_bases
GGAATAATATGGCTAGAGTCTCTCTTTCATGGGCATTGATTCTTGGTCTTTTAGCCGGTATCGGCCCGATGTGTACCGAT
CTTTATTTGCCGGCTTTGCC

Product: multidrug efflux outer membrane protein EefC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQVVTIALNSNRDVQKAIADIDS
ARALYGQTNASLFPTVNAALSSTRSRSLANGTGTTAEADGTVSSYTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIA
EISTAWLTLAADNSNLALAKETMASAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAG
TTLAENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFFPTISLTASAGVGSDALSSLF
SHGMQIWSFAPSVTLPLFTGGSNLAQLRYAEAQKRGLIATYEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTV
DVGLRRYQAGVGDYLTVLTAQRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK

Sequences:

>Translated_457_residues
MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQVVTIALNSNRDVQKAIADIDS
ARALYGQTNASLFPTVNAALSSTRSRSLANGTGTTAEADGTVSSYTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIA
EISTAWLTLAADNSNLALAKETMASAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAG
TTLAENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFFPTISLTASAGVGSDALSSLF
SHGMQIWSFAPSVTLPLFTGGSNLAQLRYAEAQKRGLIATYEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTV
DVGLRRYQAGVGDYLTVLTAQRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK
>Mature_457_residues
MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQVVTIALNSNRDVQKAIADIDS
ARALYGQTNASLFPTVNAALSSTRSRSLANGTGTTAEADGTVSSYTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIA
EISTAWLTLAADNSNLALAKETMASAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAG
TTLAENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFFPTISLTASAGVGSDALSSLF
SHGMQIWSFAPSVTLPLFTGGSNLAQLRYAEAQKRGLIATYEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTV
DVGLRRYQAGVGDYLTVLTAQRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK

Specific function: The outer membrane component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solven

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=456, Percent_Identity=36.4035087719298, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI2367348, Length=343, Percent_Identity=25.6559766763848, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49120; Mature: 49120

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQV
CCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHE
VTIALNSNRDVQKAIADIDSARALYGQTNASLFPTVNAALSSTRSRSLANGTGTTAEADG
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TVSSYTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIAEISTAWLTLAADNSNLALAK
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECEEEEEEEECCCCCCHHH
ETMASAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TTLAENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHCCCC
PTISLTASAGVGSDALSSLFSHGMQIWSFAPSVTLPLFTGGSNLAQLRYAEAQKRGLIAT
CEEEEEECCCCCHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHH
YEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTVDVGLRRYQAGVGDYLTVLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQV
CCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHE
VTIALNSNRDVQKAIADIDSARALYGQTNASLFPTVNAALSSTRSRSLANGTGTTAEADG
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TVSSYTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIAEISTAWLTLAADNSNLALAK
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECEEEEEEEECCCCCCHHH
ETMASAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TTLAENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHCCCC
PTISLTASAGVGSDALSSLFSHGMQIWSFAPSVTLPLFTGGSNLAQLRYAEAQKRGLIAT
CEEEEEECCCCCHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHH
YEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTVDVGLRRYQAGVGDYLTVLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]