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The map label for this gene is xanP [H]

Identifier: 170026389

GI number: 170026389

Start: 4612362

End: 4613780

Strand: Direct

Name: xanP [H]

Synonym: YPK_4182

Alternate gene names: 170026389

Gene position: 4612362-4613780 (Clockwise)

Preceding gene: 170026387

Following gene: 170026390

Centisome position: 98.36

GC content: 50.81

Gene sequence:

>1419_bases
ATGCCCCCTTTGCCGATCTGGAAATACCACGCCATGTCTACGCAATCTGCCGAACTTGATACTGCACCGCCATCACCGGC
TCGCCCCAGCGAATTGATCTACCACCTAGAAGACCGACCGCCACTCCCACAAACACTGTTTGCCGCTTGCCAGCATCTCT
TGGCGATGTTTGTTGCGGTAATCACCCCCGGTTTATTGATTTGTCAGGCTTTGGGGTTACCCGCAGAAGATACTCAACGC
ATTATTAGTATGTCGTTATTTGCTTCGGGCCTAGCGTCTTTACTGCAGATTAAAACTTGGGGCCCCGTGGGTTCAGGCCT
GTTATCCATTCAAGGCACCAGTTTTAACTTTGTTTCTCCGTTGATTATGGGGGGGCTGGCGCTAAAAAACGGTGGGGCAG
ATATCCCAACGATGATGGCGGCGCTGTTCGGTACGTTAATGGTTGCGTCCTGCACCGAGATCTTACTCTCACGTGTGCTG
CATCTGGCACGCCGTATTATCACCCCGCTGGTATCCGGTATTGTGGTGATGATTATCGGCCTGTCATTGATTCAAGTTGG
GCTGACATCTATTGGTGGTGGTTATGGTGCGATGAGCGATAACACCTTTGGTGCACCGAAAAACTTATTATTAGCCGGTG
CCGTATTGGGGGTGATCATTCTGCTTAACCGCCAGCGTAACCCGTATTTACGTGTTGCCTCTTTGGTTATCGCTATGGCC
GTGGGTTATCTGCTCGCCTGGGCATTGGGGATGTTGCCTGAGAGCCGCCCAGTTGTAGATACCGCGCTGATTACTATTCC
AACGCCGTTGTACTATGGGCTGTCCTTCGACTGGAACTTACTGATTCCTCTGATGCTGATCTTTATGGTGACCTCACTGG
AAACCATAGGCGATATTACCGCAACATCTGATGTATCAGAGCAACCGGTTCGCGGCCCGTTATATATGAAACGCCTAAAA
GGCGGTGTACTGGCCAATGGTTTGAACTCGATGCTGTCCGCTATATTCAATACCTTCCCCAACTCCTGCTTCGGTCAGAA
TAATGGCGTGATCCAATTGACCGGCGTTGCCAGCCGTTATGTCGGTTTTGTTGTGGCAATAATGCTCATCATTTTGGGCC
TGTTCCCTGCTGTCGCTGGGTTTGTGCAGCATATTCCTGAGCCGGTACTGGGTGGAGCAACTCTCGTGATGTTCGGGACT
ATCGCAGCGTCTGGAGTGCGTATTGTGTCACGCGAGACCCTGAATCGCCGGGCGATTATGATAATGGCCTTATCATTAGC
GGTTGGTATGGGTGTCGCACAGCAGCCATTGATTTTGCAATTTGCGCCTGACTGGATCAAAACGCTGTTCTCTTCTGGGA
TTGCCGCTGGCGGTATTACTGCCATCGTACTTAACTTACTCTTCCCACAAGAAAAATAG

Upstream 100 bases:

>100_bases
AGAATACAAGTTTAGTTATAAAAAATGTGAGTTAGCAAAAAAATAGAAATAATATAAAAACCCAGCGCAAACGATTGCTT
TTGTGAGCCGGATCATTAAA

Downstream 100 bases:

>100_bases
TCTTTACGCTAACACATCACCTAAATGGCCGGTCATTAATGATACCGGCCATTTTTTATGGTCCGATAGCTGATTATCTA
TTGAGCTAATGGAAAAATTG

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MPPLPIWKYHAMSTQSAELDTAPPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQR
IISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVL
HLARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMA
VGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLK
GGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGT
IAASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Sequences:

>Translated_472_residues
MPPLPIWKYHAMSTQSAELDTAPPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQR
IISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVL
HLARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMA
VGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLK
GGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGT
IAASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
>Mature_471_residues
PPLPIWKYHAMSTQSAELDTAPPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRI
ISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLH
LARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAV
GYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKG
GVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTI
AASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI40316845, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=84.1991341991342, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=440, Percent_Identity=46.5909090909091, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=31.0869565217391, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=27.0676691729323, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081818, Length=447, Percent_Identity=25.7270693512304, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=450, Percent_Identity=24, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=269, Percent_Identity=26.7657992565056, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 50014; Mature: 49883

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLPIWKYHAMSTQSAELDTAPPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAV
CCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
ITPGLLICQALGLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSP
HCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHH
LIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIG
HHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMA
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDIT
HHHHHHHHHHCCCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
ATSDVSEQPVRGPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRY
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHH
VGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PPLPIWKYHAMSTQSAELDTAPPSPARPSELIYHLEDRPPLPQTLFAACQHLLAMFVAV
CCCCCEEECCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
ITPGLLICQALGLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSP
HCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHH
LIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIG
HHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMA
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDIT
HHHHHHHHHHCCCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
ATSDVSEQPVRGPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRY
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHH
VGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]