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The map label for this gene is sthA [H]

Identifier: 170026285

GI number: 170026285

Start: 4501595

End: 4502995

Strand: Direct

Name: sthA [H]

Synonym: YPK_4078

Alternate gene names: 170026285

Gene position: 4501595-4502995 (Clockwise)

Preceding gene: 170026281

Following gene: 170026287

Centisome position: 95.99

GC content: 48.39

Gene sequence:

>1401_bases
ATGCAACAGCACTTCCATTTTGATGCCATTGTGATTGGCTCGGGCCCTGGCGGTGAAGGTGCCGCGATGGGGCTGGTCAA
GCAAGGGGCACGCGTTGCCGTGATTGAACGGTATAATAATGTGGGTGGCGGATGTACCCATTGGGGTACCATTCCTTCTA
AAGCCTTGCGCCACGCCGTTAGCCGTATTATCGAGTTCAACCAAAACCCCCTCTACAGCGACAATGCCAGAACCATAAAA
TCCTCTTTCGCTGATATTTTAAACCATGCAGATCGTGTTATTAATCAGCAAACCCGTATGCGGCAAGGCTTTTATGATCG
CAACCATTGCCACATGTTCTCAGGTGATGCCAGCTTCATTGATGCCAATACGGTTAATGTGCGTTACGCCGACGGTACCA
GTGATACCTTGCAGGCCGATAACATTGTCATTGCAACTGGCTCGCGCCCTTATCGCCCAGTCAATGTTGATTTTAACCAT
GAACGCATTTATGACAGCGATACCATTTTGCAGCTCAGCCATGAGCCACAGCACGTCATTATTTATGGTGCAGGGGTGAT
TGGTTGCGAATATGCGTCTATCTTCCGTGGGTTGAGTGTCAAAGTCGATTTGATCAATACCCGTGACCGCCTACTGGCTT
TCCTTGATCAGGAAATGTCAGATGCGCTCTCTTATCACTTCTGGAATAACGGCGTGGTTATCCGCCATAACGAAGAATTT
GAGCAGATTGAAGGGACAACGGACGGCGTGATTGTCCATTTGAAATCAGGCAAAAAGGTCAAAGCAGACTGCTTGTTATA
TGCTAATGGACGAACAGGTAATACCAGCGGTTTAGGCTTGGAAAATATTGGCCTGGAAGCCGATAGCCGTGGTTTGCTGA
AAGTGAACAGCATGTACCAAACCGCGCTGTCTCATGTCTATGCTGTCGGTGATGTGATTGGTTACCCAAGTCTGGCATCT
GCGGCTTATGATCAGGGGCGTATTGCTGCACAAGCCATGATCAAAGGTGAAGCCAACGTTCACCTGATTGAAGATATCCC
GACAGGCATTTACACCATTCCTGAAATCAGTTCTGTCGGGAAAACCGAACAAGAGCTGACGGCGATGAAAGTGCCCTACG
AAGTGGGCCGGGCGCAATTTAAACATCTGGCGCGGGCGCAAATTGTTGGGATGGATACCGGTAGTTTGAAAATCCTGTTC
CATCGGGAAACGAAGCAAATTTTGGGTATTCATTGCTTTGGTGAACGTGCTGCTGAAATTATCCACATCGGGCAAGCTAT
CATGGAACAGAAAGGAGAAGGCAATACGCTCGAGTATTTCGTTAATACTACCTTCAACTACCCAACCATGGCAGAAGCCT
ACCGTGTGGCCGCACTCAATGGCTTAAATCGCCTGTTCTAA

Upstream 100 bases:

>100_bases
ACAACACACATTATGGTGATTCCCCTATCGTTGATTGGGTTCTGCCTAAGATGATGTTAATGTATCGTTGTAATTTTGTA
TAAAAACAGGTCTCTCCTAC

Downstream 100 bases:

>100_bases
TGATGGGGCCATGCGCTCTTGCATGTGATCACGTATTGCCTCGGCAAGTTGTTCATAGCGGCCACGCAATGGAGAACCGG
GGCGATACACCAACGCAATG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDNARTIK
SSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFIDANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNH
ERIYDSDTILQLSHEPQHVIIYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEF
EQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQTALSHVYAVGDVIGYPSLAS
AAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILF
HRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_466_residues
MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDNARTIK
SSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFIDANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNH
ERIYDSDTILQLSHEPQHVIIYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEF
EQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQTALSHVYAVGDVIGYPSLAS
AAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILF
HRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_466_residues
MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDNARTIK
SSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFIDANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNH
ERIYDSDTILQLSHEPQHVIIYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEF
EQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQTALSHVYAVGDVIGYPSLAS
AAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILF
HRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=478, Percent_Identity=30.9623430962343, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI22035672, Length=464, Percent_Identity=27.1551724137931, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=26.3616557734205, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=24.0909090909091, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI33519430, Length=441, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI33519428, Length=441, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI33519426, Length=441, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI148277065, Length=441, Percent_Identity=24.4897959183673, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI148277071, Length=441, Percent_Identity=24.4897959183673, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI291045268, Length=315, Percent_Identity=25.3968253968254, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI21389617, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI226437568, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI65787454, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=83.4763948497854, Blast_Score=823, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=477, Percent_Identity=29.3501048218029, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=26.7241379310345, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=27.2517321016166, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.9349240780911, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=26.0042283298097, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=341, Percent_Identity=26.099706744868, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=341, Percent_Identity=26.099706744868, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=257, Percent_Identity=28.4046692607004, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559934, Length=241, Percent_Identity=24.0663900414938, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=481, Percent_Identity=29.1060291060291, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=26.1904761904762, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=26.4270613107822, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=31.1965811965812, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24640549, Length=488, Percent_Identity=26.6393442622951, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24640553, Length=484, Percent_Identity=26.6528925619835, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640551, Length=484, Percent_Identity=26.6528925619835, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=24.6913580246914, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51383; Mature: 51383

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAV
CCCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYSDNARTIKSSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFI
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
DANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNHERIYDSDTILQLSHEPQHVI
ECCEEEEEECCCCCCCEECCCEEEEECCCCCCEEECCCCCCEECCCCCEEEECCCCCEEE
IYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEF
EEECCCHHCCHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHH
EQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQ
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEEHHHHH
TALSHVYAVGDVIGYPSLASAAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVG
HHHHHHHHHHHHHCCCCHHHHHHCCCHHEEEHEEECCCCEEEEECCCCCEEECCCCHHCC
KTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILFHRETKQILGIHCFGERAAEI
CCHHHHHEEECCHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCEEEEEEEECHHHHHH
IHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAV
CCCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYSDNARTIKSSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFI
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
DANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNHERIYDSDTILQLSHEPQHVI
ECCEEEEEECCCCCCCEECCCEEEEECCCCCCEEECCCCCCEECCCCCEEEECCCCCEEE
IYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEF
EEECCCHHCCHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHH
EQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQ
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEEHHHHH
TALSHVYAVGDVIGYPSLASAAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVG
HHHHHHHHHHHHHCCCCHHHHHHCCCHHEEEHEEECCCCEEEEECCCCCEEECCCCHHCC
KTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILFHRETKQILGIHCFGERAAEI
CCHHHHHEEECCHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCEEEEEEEECHHHHHH
IHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA