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The map label for this gene is grxC [C]

Identifier: 170026287

GI number: 170026287

Start: 4504042

End: 4504773

Strand: Direct

Name: grxC [C]

Synonym: YPK_4080

Alternate gene names: 170026287

Gene position: 4504042-4504773 (Clockwise)

Preceding gene: 170026285

Following gene: 170026288

Centisome position: 96.05

GC content: 46.31

Gene sequence:

>732_bases
ATGTTTACTAGCCAAGAAGGTAAAAAAGTCCCGCAGGTAACTTTCCATACCCGTCAGGGCGACCAGTGGATTGACGTAAC
AACCGACGATTTATTCAGTAATAAAACCGTGATTGTATTTTCACTACCGGGTGCCTTTACCCCAACCTGTTCTTCCAGTC
ATCTGCCACGTTATAACGAATTAGCGGGTGTATTTAAACAACACGGTGTTGATAGCATTCTGTGTGTGTCGGTCAATGAT
ACCTTCGTAATGAACGCTTGGAAATCAGATCAACACGCTGAAAATATTACATTTGTTCCAGATGGTAACGGTGAGTTTAC
CAAAGGGATGAATATGTTGGTTGAGAAAGCAGATCTGGGCTTCGGTCCACGTTCATGGCGTTACTCCATGCTGGTACGTA
ATGGCGTGGTAGAAAAAATGTTTGTCGAGCCAAACAAACCGGGCGACCCGTTTGAAGTATCTGATGCCGACACCATGTTG
AAATATCTGGCACCTGATTTTAAAGTGCAGGAATCCGTGGCTGTCTTTACCAAACCGGGCTGCCCATTCTGTGCCAAAGC
GAAACAAATGCTGCAAGATCATGGCCTTCAATATGAAGAAATTGTATTGGGTAAAGATGCAACGACCGTCAGCTTGCGTG
CTGTAAGCGGCCGCTCCACGGTGCCACAGATCTTTATCGGAGGCCGTCACATTGGTGGCAGCGACGATCTGGAAAAGTAC
CTACCAGCCTAA

Upstream 100 bases:

>100_bases
CAGTGATTAGAACTATCAAGAGATAAAATTAATAATATGACCCAACAAAGAGACACCCAAAAAAATCTAACTTTTCTATT
TTTTAATGAAGGAATTACAG

Downstream 100 bases:

>100_bases
TTATGTTGATTAACAAACATATTAATAAAAATTAAAGCAATAGGAAGTAACTTGGTAGGCTCCGGCCTACCTTTTTTTCT
GTTAGGAGTAGACATGAAAA

Product: glutaredoxin family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTDDLFSNKTVIVFSLPGAFTPTCSSSHLPRYNELAGVFKQHGVDSILCVSVND
TFVMNAWKSDQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPDFKVQESVAVFTKPGCPFCAKAKQMLQDHGLQYEEIVLGKDATTVSLRAVSGRSTVPQIFIGGRHIGGSDDLEKY
LPA

Sequences:

>Translated_243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTDDLFSNKTVIVFSLPGAFTPTCSSSHLPRYNELAGVFKQHGVDSILCVSVND
TFVMNAWKSDQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPDFKVQESVAVFTKPGCPFCAKAKQMLQDHGLQYEEIVLGKDATTVSLRAVSGRSTVPQIFIGGRHIGGSDDLEKY
LPA
>Mature_243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTDDLFSNKTVIVFSLPGAFTPTCSSSHLPRYNELAGVFKQHGVDSILCVSVND
TFVMNAWKSDQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPDFKVQESVAVFTKPGCPFCAKAKQMLQDHGLQYEEIVLGKDATTVSLRAVSGRSTVPQIFIGGRHIGGSDDLEKY
LPA

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=145, Percent_Identity=36.551724137931, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790039, Length=67, Percent_Identity=44.7761194029851, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323138, Length=134, Percent_Identity=34.3283582089552, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=47.2, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=47.2, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26893; Mature: 26893

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTSQEGKKVPQVTFHTRQGDQWIDVTTDDLFSNKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEEEEECCCCEEEEEECHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAGVFKQHGVDSILCVSVNDTFVMNAWKSDQHAENITFVPDGNGEFTKGMNMLVEKADLG
HHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
FGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTMLKYLAPDFKVQESVAVFTKPG
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCEECCCHHHHHHHHCCCCEECCCEEEEECCC
CPFCAKAKQMLQDHGLQYEEIVLGKDATTVSLRAVSGRSTVPQIFIGGRHIGGSDDLEKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCEECCCCHHHHHH
LPA
CCC
>Mature Secondary Structure
MFTSQEGKKVPQVTFHTRQGDQWIDVTTDDLFSNKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEEEEECCCCEEEEEECHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAGVFKQHGVDSILCVSVNDTFVMNAWKSDQHAENITFVPDGNGEFTKGMNMLVEKADLG
HHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
FGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTMLKYLAPDFKVQESVAVFTKPG
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCEECCCHHHHHHHHCCCCEECCCEEEEECCC
CPFCAKAKQMLQDHGLQYEEIVLGKDATTVSLRAVSGRSTVPQIFIGGRHIGGSDDLEKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCEECCCCHHHHHH
LPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]