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The map label for this gene is gppA [H]

Identifier: 170026247

GI number: 170026247

Start: 4453331

End: 4454827

Strand: Direct

Name: gppA [H]

Synonym: YPK_4037

Alternate gene names: 170026247

Gene position: 4453331-4454827 (Clockwise)

Preceding gene: 170026246

Following gene: 170026249

Centisome position: 94.97

GC content: 50.7

Gene sequence:

>1497_bases
ATGATGCTAAGTTCCACCTCACTTTATGCTGCCATCGATCTTGGCTCCAATAGTTTTCATATGTTGGTAGTACGTGAGGT
GGCTGGCAGTATCCAAACGCTGGCACGTATTAAGCGGAAGGTCCGCCTGGCGGCTGGTCTGGATAACCAAAATCATCTAT
CGCAGGAAGCGATGGAACGAGGCTGGCAATGCCTAAAACTTTTCTCAGAGCGTTTACAGGATATTCCTCTGGATCAAATC
CGCGTGGTCGCAACGGCAACCTTGCGCCTGGCCTCTAATGCCGACGAATTCTTGCGTACTGCAACCGAGATCCTCGGCTG
CCCTATTCAAGTCATCAGTGGCGAAGAAGAAGCCCGTCTGATTTATCATGGCGTAGCGCATACGACTGGCGGGCCAGAAC
AGCGGTTGGTCGTCGATATTGGGGGGGGCAGCACTGAGTTGGTTACAGGCAATGGGGCTCAGGCGAATATTTTGGTCAGC
CTATCAATGGGTTGTGTTACCTGGTTAGAACGTTATTTTGGTGACCGCCATCTGGCAAAGGAAAATTTTGAACGCGCTGA
ATTGGCCGCTCATGAGATGATCAAGCCCGTCGCCCAACGTTTTCGTGAACATGGCTGGCAAGTTTGTGTCGGCGCTTCAG
GCACCGTTCAGGCACTACAAGAGATCATGGTCGCTCAAGGTATGGACGAGCTGATCACCTTAGCCAAGCTGCAACAGCTC
AAACAAAGAGCGATTCAGTGTGGCAAATTAGAAGAGTTGGAAATCCCTGGTTTAACCTTGGAACGAGCGCTGGTCTTCCC
CAGTGGTCTGTCCATCTTAATTGCGATATTCCAGGAGTTGTCCATTGAAAGCATGACACTGGCAGGTGGCGCACTGCGCG
AAGGGCTGGTCTATGGCATGCTCCATTTACCGGTCGAGCAAGATATTCGCCGCCGGACACTACGTAATTTACAGCGCCGC
TATTTACTGGATACCGAGCAAGCTAAGCGCGTCAGTTGTTTGGCGGATAACTTTTTCCTACAAGTGGAAAAAGAGTGGCA
TCTCGATGGCCGATGTCGCGAATTTTTGCAAAACGCCTGTTTGATCCATGAAATTGGCCTCAGTGTCGATTTTAAACATG
CTCCGCAACATGCCGCTTATCTGATCCGTAATCTGGATCTACCCGGTTTTACCCCTGCACAAAAGCTGCTACTTTCTGCT
CTGTTACAAAACCAGAGTGACACTATCGACCTATCGCTCTTGAACCAGCAGAATGCATTACCTGCCGACATGGCACAGCA
TTTGTGTCGTCTACTGCGCTTGGCCATTATTTTTTCCAGCCGTCGCCGGGATGATACCCTGCCAGCAGTCAGGTTGCGGG
CCGATAATAATGCGCTTTATGTGCTGGTCCCCCAAGGTTGGTTGGAACAGCACCCCTACCGCGCCGAAGCGTTAGAACAA
GAGAGTCACTGGCAAAGTTATGTTCAATGGCCACTGCTATTGGAAGAGCTTAGCTAA

Upstream 100 bases:

>100_bases
ACGCCTGGCCCGTACCCGCACCGGGAATGGCCCACGCCGTAATTCTGCCCCACGCCGCAGTGGAGCACCACGGAATAACC
GTAAGCGACCAGGCTGATAA

Downstream 100 bases:

>100_bases
GTGTGTTGGTGGGGATTACCCATAGCATTTCAGCGACGTTAAAAACGTCACGGTTGATGGTCAATCAGTCGCGCCTTAAT
GCATGGCTAACGGGCAATAG

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVS
LSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQL
KQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRR
YLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSA
LLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQ
ESHWQSYVQWPLLLEELS

Sequences:

>Translated_498_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVS
LSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQL
KQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRR
YLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSA
LLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQ
ESHWQSYVQWPLLLEELS
>Mature_498_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVS
LSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQL
KQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRR
YLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSA
LLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQ
ESHWQSYVQWPLLLEELS

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=491, Percent_Identity=74.745417515275, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=499, Percent_Identity=38.2765531062124, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55927; Mature: 55927

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMER
CCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GWQCLKLFSERLQDIPLDQIRVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCEE
IYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVSLSMGCVTWLERYFGDRHLAK
EEEEHHCCCCCCCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHCCHHHHH
ENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
KQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGM
HHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
LHLPVEQDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNAC
HHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCH
LIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNAL
HHHHHCCCEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCHHHCCCCHHHHHHH
ESHWQSYVQWPLLLEELS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMER
CCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GWQCLKLFSERLQDIPLDQIRVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCEE
IYHGVAHTTGGPEQRLVVDIGGGSTELVTGNGAQANILVSLSMGCVTWLERYFGDRHLAK
EEEEHHCCCCCCCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHCCHHHHH
ENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQGMDELITLAKLQQL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
KQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGM
HHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
LHLPVEQDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNAC
HHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCH
LIHEIGLSVDFKHAPQHAAYLIRNLDLPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNAL
HHHHHCCCEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCHHHCCCCHHHHHHH
ESHWQSYVQWPLLLEELS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA