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The map label for this gene is aroP [H]

Identifier: 170025709

GI number: 170025709

Start: 3840134

End: 3841531

Strand: Direct

Name: aroP [H]

Synonym: YPK_3494

Alternate gene names: 170025709

Gene position: 3840134-3841531 (Clockwise)

Preceding gene: 170025708

Following gene: 170025712

Centisome position: 81.89

GC content: 48.43

Gene sequence:

>1398_bases
ATGAGTGATCAACAAGAGGGTGCTGAGCTAAAACGGGGGCTTAAAAACCGCCATATTCAGCTTATTGCCCTAGGTGGTGC
AATTGGTACCGGACTATTCCTCGGCATAGCACAGACCATCAAAATGGCTGGGCCTTCGGTTTTACTGGGGTACGCAATTG
GGGGTTTTATTGCGTTTCTGATAATGCGCCAGCTAGGCGAAATGGTGGTTGAAGAACCTGTAGCCGGTTCCTTTAGCCAC
TTTGCGTATAAATATTGGGGACACTTTGCCGGTTTTGCTTCTGGCTGGAACTACTGGGTGCTGTATGTGTTGGTGGCGAT
GGCCGAACTAACCGCAGTGGGGATCTATGTGCAATATTGGTGGCCAGAAATCCCTACCTGGGTCTCCGCCGCCGTCTTCT
TCTTGGCCATCAACGCCATCAACCTGGCTAACGTAAAAGTCTATGGTGAGATGGAGTTTTGGTTTGCCATCATTAAAGTG
ATCGCGATTATTGCGATGATTTTATTTGGCGGTTACCTGCTCATCAGTGGCCGGGGTGGCCCAGAAGCCACGGTAACCAA
CTTATGGGCCCAAGGCGGTTTCTTCCCGAATGGCATCATGGGTCTGGTGATGGCAATGGCGGTAATTATGTTCTCTTTCG
GTGGCCTTGAATTAGTGGGTATCACCGCAGCAGAAGCAGAAGACCCGGCCAAAAGCATTCCGAAGGCAACCAATCAGGTT
ATCTACCGTATTCTTCTGTTTTATATTGGTTCTCTGGCAATCTTGTTATCACTCTATCCATGGGGAAAAGTGGTCGAAGG
CGGCAGCCCATTCGTATTGATTTTCGATGCGCTGGACAGTAATTCAGTCGCCACTGTCTTGAATATTGTCGTACTGACGG
CGGCACTCTCGGTCTACAACAGTTGCGTATACTGTAACAGCCGCATGTTGTTTGGTTTAGCTAAACAAGGTAATGGCCCG
AAAATCCTGTTGAAAGTGGATGGCCGAGGTGTTCCAGTCATTGCGATTGCTGTTTCTGCGTTTGCTACCGCGTTTTGTGT
ACTGATTAACTACCTGTTACCTAGCCGTGCCTTTGAATTACTGATGGCATTAGTGGTATCCGCGTTGGTGATCAACTGGG
CGATGATTAGCCTGGCACACCTGAAATTCCGTGCGGCGAAAAACCGCCAGGGCGTAATACCAAAATTCAAAGCATTTTGG
TATCCGTTCGGTAACTGTTTGTGTTTGTTGTTCCTGACCGGCATCTTAGTGATCATGTTTCTGACACCCAGCATCCGGAT
TTCAGTGATACTTATTCCTGTCTGGGTAGTCGTCCTAGCGATTGGTTATATTCTGAAGAATCAGAGCCAACGTCAGAATC
AGCAACTGAGCGCTAGCAGCAGGAAAGCAACCAAGTAA

Upstream 100 bases:

>100_bases
ATGAATATCGCTAGCGTCTCTGTAACGTCCAATGATGAAGGGTATAGCAAAAAACTAAGATTAAGCCCGCGAGTAGTCAC
AACGACAAAGGATGTAATTG

Downstream 100 bases:

>100_bases
AGAACAACCCATTTCCTTATAAATCAGTTAGTTAACCCTATCTAGGCCAGCACTTAGTGCTGGCCTAGGCTATTGACAAA
GTACCGATGGCGAAGAGAAC

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKV
IAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQV
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
KILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPSRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFW
YPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK

Sequences:

>Translated_465_residues
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKV
IAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQV
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
KILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPSRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFW
YPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
>Mature_464_residues
SDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHF
AYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVI
AIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQVI
YRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGPK
ILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPSRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWY
PFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=397, Percent_Identity=21.6624685138539, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI110347453, Length=284, Percent_Identity=25, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=76.0532150776053, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=442, Percent_Identity=66.5158371040724, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=46.1368653421634, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=41.3394919168591, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=38.9130434782609, Blast_Score=330, Evalue=8e-92,
Organism=Escherichia coli, GI87081915, Length=449, Percent_Identity=37.4164810690423, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=36.405529953917, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=34.3949044585987, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788480, Length=442, Percent_Identity=34.6153846153846, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=35.6347438752784, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=436, Percent_Identity=34.4036697247706, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322892, Length=403, Percent_Identity=36.2282878411911, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=487, Percent_Identity=31.211498973306, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=404, Percent_Identity=31.6831683168317, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=33.1828442437923, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=423, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=408, Percent_Identity=29.656862745098, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=31.3253012048193, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=28.1179138321995, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=28.8177339901478, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=28.8557213930348, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=30, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=29.426433915212, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=418, Percent_Identity=29.4258373205742, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.030303030303, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=25.5489021956088, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667468, Length=399, Percent_Identity=24.812030075188, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668806, Length=379, Percent_Identity=24.0105540897098, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356285, Length=379, Percent_Identity=24.0105540897098, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668802, Length=379, Percent_Identity=24.0105540897098, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666159, Length=288, Percent_Identity=23.6111111111111, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221512776, Length=344, Percent_Identity=22.3837209302326, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50612; Mature: 50481

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEE
WPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRGG
CCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPSRAFEL
HHHHCCCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIMF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
LTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEE
WPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRGG
CCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPSRAFEL
HHHHCCCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIMF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
LTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]