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The map label for this gene is nadC [H]

Identifier: 170025712

GI number: 170025712

Start: 3843740

End: 3844648

Strand: Direct

Name: nadC [H]

Synonym: YPK_3497

Alternate gene names: 170025712

Gene position: 3843740-3844648 (Clockwise)

Preceding gene: 170025709

Following gene: 170025713

Centisome position: 81.97

GC content: 48.84

Gene sequence:

>909_bases
ATGCCGCCCCGCTGCTACAATTCCAACAGCCGCCGCGCCGAGCTATTGGAACGAATTCAAAGTGATATACCTGCGACTGT
TGCTCAGGCACTGAGTGAAGACCTAGGCGGAGAGGTCAATGCAGACCGTGATCTCACCGCACAATTACTCCCCGCAGATA
AACAAGCTACCGCCACAATTATTACCCGTGAGGACGGTATCTTTTGTGGGCAACGCTGGTTGAATGAAGTCTTCATTCAA
CTGGGTGCGCAAATCTCAATTCAGTGGCTGGTTACAGATGGCGATAAACTGACAGCCAATCAAACACTTTGCCATTTGAC
CGGACCTGCTCGCATTTTGCTGACAGGTGAGCGCACCGCACTTAACTTCCTGCAAACGCTATCTGGGGTTGCCACCGAGG
TCAGCCGCTATGTTGTACAACTCGCGGGGCTAAAAACACAACTACTCGATACTCGCAAGACACTACCAGGCCTGCGTACT
GCATTAAAATATGCCGTCCTCTGTGGTGGTGGTAATAACCATCGGCTCGGTTTATCTGACGCCTTCCTAATCAAAGAGAA
TCATATTATTGCAGCCGGTTCGATTAAAGAAGCCGTTGCCAAAGCCTTTTGGATACATGCCGATGTCCCTATCGAGGTTG
AAGTCGAATCCCTTGATGAATTACAGCAAGCACTAGAAGCAGGTGCAGATATCGTTATGTTAGATAATTTCACCATTCCA
ATGATGCGTGATGCCGTAAAAATGCGCGATGACCATGCCAAGACTCAAGGCAGTGCACAATTGGAGGTCTCGGGTAATGT
CACTTTAGAAACGTTACGCAGTTACGCTGAAACCGGCATTGACTTCATCTCAGTAGGGGCGCTTACCAAGCACATAACAG
CGTTAGACCTCTCAATGCGTTTCCAGTAA

Upstream 100 bases:

>100_bases
TCACCCTGATCGTTCACTTTGAACGGCTCTTTGATGGCACTTCAGCCTGCAACAGGGTAGCATGTTTAGACGATTGTCTA
TTCGCCATTTCGGAGTTTAT

Downstream 100 bases:

>100_bases
CTCTACCAAACTATCTTCGGCGGATAGCCATTATTATCAGGTCAATATCCTGTTTTGCGAGTGCCGCCGAAGTTATCTGT
TACGTTATTGCAATAACCTA

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPPRCYNSNSRRAELLERIQSDIPATVAQALSEDLGGEVNADRDLTAQLLPADKQATATIITREDGIFCGQRWLNEVFIQ
LGAQISIQWLVTDGDKLTANQTLCHLTGPARILLTGERTALNFLQTLSGVATEVSRYVVQLAGLKTQLLDTRKTLPGLRT
ALKYAVLCGGGNNHRLGLSDAFLIKENHIIAAGSIKEAVAKAFWIHADVPIEVEVESLDELQQALEAGADIVMLDNFTIP
MMRDAVKMRDDHAKTQGSAQLEVSGNVTLETLRSYAETGIDFISVGALTKHITALDLSMRFQ

Sequences:

>Translated_302_residues
MPPRCYNSNSRRAELLERIQSDIPATVAQALSEDLGGEVNADRDLTAQLLPADKQATATIITREDGIFCGQRWLNEVFIQ
LGAQISIQWLVTDGDKLTANQTLCHLTGPARILLTGERTALNFLQTLSGVATEVSRYVVQLAGLKTQLLDTRKTLPGLRT
ALKYAVLCGGGNNHRLGLSDAFLIKENHIIAAGSIKEAVAKAFWIHADVPIEVEVESLDELQQALEAGADIVMLDNFTIP
MMRDAVKMRDDHAKTQGSAQLEVSGNVTLETLRSYAETGIDFISVGALTKHITALDLSMRFQ
>Mature_301_residues
PPRCYNSNSRRAELLERIQSDIPATVAQALSEDLGGEVNADRDLTAQLLPADKQATATIITREDGIFCGQRWLNEVFIQL
GAQISIQWLVTDGDKLTANQTLCHLTGPARILLTGERTALNFLQTLSGVATEVSRYVVQLAGLKTQLLDTRKTLPGLRTA
LKYAVLCGGGNNHRLGLSDAFLIKENHIIAAGSIKEAVAKAFWIHADVPIEVEVESLDELQQALEAGADIVMLDNFTIPM
MRDAVKMRDDHAKTQGSAQLEVSGNVTLETLRSYAETGIDFISVGALTKHITALDLSMRFQ

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=259, Percent_Identity=36.6795366795367, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786299, Length=303, Percent_Identity=68.3168316831683, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=35.9861591695502, Blast_Score=152, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32953; Mature: 32822

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRCYNSNSRRAELLERIQSDIPATVAQALSEDLGGEVNADRDLTAQLLPADKQATATI
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCCEEEE
ITREDGIFCGQRWLNEVFIQLGAQISIQWLVTDGDKLTANQTLCHLTGPARILLTGERTA
EEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCEEEEECCCEEEEEECCHHH
LNFLQTLSGVATEVSRYVVQLAGLKTQLLDTRKTLPGLRTALKYAVLCGGGNNHRLGLSD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHEEEEECCCCCCEECCCC
AFLIKENHIIAAGSIKEAVAKAFWIHADVPIEVEVESLDELQQALEAGADIVMLDNFTIP
EEEEECCCEEEECCHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCCH
MMRDAVKMRDDHAKTQGSAQLEVSGNVTLETLRSYAETGIDFISVGALTKHITALDLSMR
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEEE
FQ
CC
>Mature Secondary Structure 
PPRCYNSNSRRAELLERIQSDIPATVAQALSEDLGGEVNADRDLTAQLLPADKQATATI
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCCEEEE
ITREDGIFCGQRWLNEVFIQLGAQISIQWLVTDGDKLTANQTLCHLTGPARILLTGERTA
EEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCEEEEECCCEEEEEECCHHH
LNFLQTLSGVATEVSRYVVQLAGLKTQLLDTRKTLPGLRTALKYAVLCGGGNNHRLGLSD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHEEEEECCCCCCEECCCC
AFLIKENHIIAAGSIKEAVAKAFWIHADVPIEVEVESLDELQQALEAGADIVMLDNFTIP
EEEEECCCEEEECCHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCCH
MMRDAVKMRDDHAKTQGSAQLEVSGNVTLETLRSYAETGIDFISVGALTKHITALDLSMR
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEEE
FQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]