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The map label for this gene is ffh [H]

Identifier: 170025580

GI number: 170025580

Start: 3690233

End: 3691594

Strand: Reverse

Name: ffh [H]

Synonym: YPK_3365

Alternate gene names: 170025580

Gene position: 3691594-3690233 (Counterclockwise)

Preceding gene: 170025583

Following gene: 170025579

Centisome position: 78.72

GC content: 48.24

Gene sequence:

>1362_bases
ATGTTTGAGAACTTAACTGATCGATTGTCGCGCACACTGCGCAATATCAGCGGCCGTGGCCGGCTGACAGAAGAAAATAT
TAAAGAAACGCTACGTGAAGTGCGCATGGCATTACTTGAAGCTGACGTCGCTCTGCCCGTTGTTCGTGACTTTATAAACC
GAGTAAAAGAGCGGGCTGTTGGGCATGAAGTTAATAAAAGTCTGACGCCAGGCCAAGAATTCGTCAAAATAGTTAAAAAT
GAATTGATCAGCGCCATGGGCGAGGTCAATAACGAACTGAATCTGGCTGCACAACCGCCAGCAGTTGTGTTAATGGCTGG
CTTGCAAGGTGCGGGTAAGACCACCAGTGTAGCGAAACTGGGGAAATTTCTTAAAGAAAAACAGAAGAAAAAAGTGCTGA
TCGTGTCTGCTGACGTTTATCGCCCTGCGGCGATCAAACAGTTGGAAACCCTGGCTCAGGGTGTTGGCATTGATTTCTTC
CCGTCTGATGCACAGGAAAAACCGATTGATATTGTGAATCGTGCCCTGCAACAGGCAAAGCTTAAATTTTATGATGTTCT
GATTGTCGATACCGCAGGTCGCTTACACGTTGATGAAGCGATGATGGACGAAATCAAACAGGTTCATGCGGCGATTAAGC
CTGTTGAAACCTTGTTTGTCGTCGATGCGATGACCGGTCAGGATGCGGCGAATACCGCCAAAGCATTCAACGAAGCACTG
CCACTCACCGGTGTCGTGCTGACTAAAGTGGATGGCGATGCGCGCGGTGGTGCGGCTTTATCTATCCGCCATATCACCGG
TAAACCTATTAAATTCCTTGGCGTCGGTGAGAAATCTGATGCACTGGAACCGTTCCATCCAGACCGAATAGCTTCACGTA
TCTTGGGTATGGGCGATGTGCTGTCGCTGATTGAAGATATCGAAAGCAAAGTTGACCGTGTGCAAGCGGAGAAACTGGCA
ACAAAACTGAAAAAAGGCGATGGTTTCGATCTCAATGACTTCCTCGACCAGTTGAAGCAGATGCGCAACATGGGGGGGAT
GGCCAGTATGTTGAGTAAAATGCCAGGGGCAGGTCAGTTGCCAGAAAACGTAAAATCGCAAATGGATGATAAAGTCACGG
TGCGGATGGAGGCGATCATCAATTCTATGACGCTGAAAGAGCGCGCTAAACCTGAAATTATCAAAGGTTCACGTAAGCGC
CGTATCGCAACCGGTTCTGGTGTGCAGGTACAGGATGTTAACCGTTTGCTGAAACAGTTTGATGAAATGCAGCGCATGAT
GAAGAAAATGAAAAACGGCGGTTTGGCCAAAATGATGCGTGGCATGAAAGGTATGATGCCACCCGGGTTCCCAGGTCGCT
AA

Upstream 100 bases:

>100_bases
AACCGTTCTCCGACGTGAGGGCAGAGATCGTTTGCACTTCGTGTTATAATCCCCTAATTGTGTCGCCAGAGCGGCCTGTT
TCCACGTTGAGTATGAGACA

Downstream 100 bases:

>100_bases
AAGCCATCTCACACTGTGGCGTTAACCGGTGTGAAGTGAGTATAGATTTCCCGCAGAAAATGGCGGTAAACGATGAAAAT
GGTACTCAGTACAAAATGTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLIVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRVQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR

Sequences:

>Translated_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLIVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRVQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
>Mature_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAVGHEVNKSLTPGQEFVKIVKN
ELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLIVSADVYRPAAIKQLETLAQGVGIDFF
PSDAQEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDVLSLIEDIESKVDRVQAEKLA
TKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQLPENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKR
RIATGSGVQVQDVNRLLKQFDEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=33.0357142857143, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI226371618, Length=350, Percent_Identity=35.4285714285714, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=39.375, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=27.1812080536913, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=27.1812080536913, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=88.5209713024283, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=35.0943396226415, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=453, Percent_Identity=30.242825607064, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=28.9473684210526, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=31.0810810810811, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=27.1565495207668, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=29.7297297297297, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.1818181818182, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49823; Mature: 49823

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKNELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHH
GKFLKEKQKKKVLIVSADVYRPAAIKQLETLAQGVGIDFFPSDAQEKPIDIVNRALQQAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRVQAEKLATKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKRRIATGSGVQVQDVNRLLKQF
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKNELISAMGEVNNELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHH
GKFLKEKQKKKVLIVSADVYRPAAIKQLETLAQGVGIDFFPSDAQEKPIDIVNRALQQAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKSDALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRVQAEKLATKLKKGDGFDLNDFLDQLKQMRNMGGMASMLSKMPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PENVKSQMDDKVTVRMEAIINSMTLKERAKPEIIKGSRKRRIATGSGVQVQDVNRLLKQF
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMKNGGLAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]