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The map label for this gene is fruA [H]

Identifier: 170024987

GI number: 170024987

Start: 3046904

End: 3048604

Strand: Reverse

Name: fruA [H]

Synonym: YPK_2762

Alternate gene names: 170024987

Gene position: 3048604-3046904 (Counterclockwise)

Preceding gene: 170024988

Following gene: 170024986

Centisome position: 65.01

GC content: 54.09

Gene sequence:

>1701_bases
ATGAAAACGCTACTAATAATTGACAGTTCGCTCGGGCAGGCCAGAGGCCATCTCGCGACACTGATGCTGGGTGCTGCGGC
GAAAAAAGCAGGATTGAGCTGGGTTGAGAAAGCCGCCGACGCTGAACTGGTGATTGTCGCGGGGTCATCCGCCCCGGCTG
ACAGTACGTTGAATGGCAAAAAAGTCTATGTAGGGGACGTGGAAAAAGCGGTTCGCGATCCTGACGGTTTTCTGGCACAG
GCTATTGCGCAGGCGGCACCTTATCAGGCCGCGGCCACCCCTGAGCCAACGTCAGTGACTGGCGCTAAACGTTCCGTCGC
TGGTCCTAAACGTATTGTAGCAATTACGGCTTGTCCGACTGGTGTTGCGCATACCTTTATGGCGGCTGAAGCCATCGAAA
GTGAAGCAAAAAAACGTGGCTGGTGGGTGAAGGTTGAAACCCGTGGTTCCGTTGGCGCAGGCAATGAGATTACGCCAGAG
GAAGTGGCTGCTGCTGATTTAGTGATTGTGGCTGCTGATATCGAAGTGGATCTGAACAAATTTGCCGGCAAACCGATGTA
CCGCACCACAACCGGTCTGGCACTGAAGAAGACGGTGCAAGAATTGGATAAAGCACTGGTCGAGGCTGACGTTTATCAGC
CGAAAACCAGTAGCAGTACGGCGAGTAAGAAAACTGAGACCGGTGGCCCTTATCGCCATCTATTGACGGGTGTGTCTTAC
ATGCTGCCAATGGTGGTTGCCGGGGGGCTGTGTATCGCTTTGTCCTTTGTCTTTGGTATTGAAGCATTCAAAGAGAAAGG
GACGTTGGCCGCCGCATTGATGCAAATCGGTGGTGATTCTGCATTTGCTTTGATGGTGCCAGTGTTAGCGGGCTTTATTG
CATTCTCCATTGCTGACCGTCCAGGTCTGACGCCAGGGTTGATTGGCGGTATGTTGGCTGTCAGCACGGGGGCGGGCTTC
CTTGGTGGTATCATTGCCGGTTTCCTGGCAGGTTATGTGGCGAAAGCCATTAGCACTAAATTGCATTTGCCACAAAGTAT
GGAAGCGCTTAAACCTATTCTGATCATTCCACTGGTTGCCAGTTTGATCGTCGGTTTAACGATGATTTATATCGTCGGTA
CACCGGTGGCAAAAATCATGACGGGCCTGACGCATTGGTTGGAGTCCATGGGGACGGCGAATGCGGTACTGCTCGGGGCT
ATCCTTGGAGCCATGATGTGTACCGATATGGGCGGCCCAGTGAATAAAGCGGCCTATGCCTTTGGTGTGGCGCTGTTGAG
TTCTTCTGTTTATGCACCGATGGCAGCCATTATGGCGGCGGGGATGGTTCCACCGCTGGCAATGGGTCTGGCAACACTGT
TGGCCCGTAATAAGTTCGACAAAGGGGAGCAGGAAGGGGGTAAAGCTGCGCTGGTACTGGGGCTGTGCTTTATTTCGGAA
GGGGCTATCCCATTTGCTGCTCGTGATCCGATGCGTGTCTTGCCGTGCTGTATCGCCGGTGGTGCATTAACGGGTGCGCT
GTCTATGGCGTTTGGTGCGCAACTGATGGCACCACACGGTGGCCTGTTTGTCCTGCTGATCCCAGGGGCTATCCATCCAG
TGCTGTTATATTTGGTGGCAATTGCTGCAGGTACCCTGCTCGCGGGCGGCTTGTATGCCATGCTGAAACGCCCTGACGCG
ATGGTGGCGAAGGTCGCGTAA

Upstream 100 bases:

>100_bases
CCGTCAGCCAGAGCAATGTCGGCATTACGGATCGCCCGCAATTGGCAGCCATGATGGCAAAAGTAGACTTGAAACCTTTT
AATTAATCTCCGGAGGCGAA

Downstream 100 bases:

>100_bases
CGCTCAACGTGCCGGCGCGTTTCAGATCGAATCATCGGCGCTTGTCAGCAGTCTGAAATGCCAGTCAGTTAATTCTGACT
GGCATTTTTTATGGGTGTTA

Product: PTS system fructose-specific transporter subunits IIBC

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKTLLIIDSSLGQARGHLATLMLGAAAKKAGLSWVEKAADAELVIVAGSSAPADSTLNGKKVYVGDVEKAVRDPDGFLAQ
AIAQAAPYQAAATPEPTSVTGAKRSVAGPKRIVAITACPTGVAHTFMAAEAIESEAKKRGWWVKVETRGSVGAGNEITPE
EVAAADLVIVAADIEVDLNKFAGKPMYRTTTGLALKKTVQELDKALVEADVYQPKTSSSTASKKTETGGPYRHLLTGVSY
MLPMVVAGGLCIALSFVFGIEAFKEKGTLAAALMQIGGDSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSTGAGF
LGGIIAGFLAGYVAKAISTKLHLPQSMEALKPILIIPLVASLIVGLTMIYIVGTPVAKIMTGLTHWLESMGTANAVLLGA
ILGAMMCTDMGGPVNKAAYAFGVALLSSSVYAPMAAIMAAGMVPPLAMGLATLLARNKFDKGEQEGGKAALVLGLCFISE
GAIPFAARDPMRVLPCCIAGGALTGALSMAFGAQLMAPHGGLFVLLIPGAIHPVLLYLVAIAAGTLLAGGLYAMLKRPDA
MVAKVA

Sequences:

>Translated_566_residues
MKTLLIIDSSLGQARGHLATLMLGAAAKKAGLSWVEKAADAELVIVAGSSAPADSTLNGKKVYVGDVEKAVRDPDGFLAQ
AIAQAAPYQAAATPEPTSVTGAKRSVAGPKRIVAITACPTGVAHTFMAAEAIESEAKKRGWWVKVETRGSVGAGNEITPE
EVAAADLVIVAADIEVDLNKFAGKPMYRTTTGLALKKTVQELDKALVEADVYQPKTSSSTASKKTETGGPYRHLLTGVSY
MLPMVVAGGLCIALSFVFGIEAFKEKGTLAAALMQIGGDSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSTGAGF
LGGIIAGFLAGYVAKAISTKLHLPQSMEALKPILIIPLVASLIVGLTMIYIVGTPVAKIMTGLTHWLESMGTANAVLLGA
ILGAMMCTDMGGPVNKAAYAFGVALLSSSVYAPMAAIMAAGMVPPLAMGLATLLARNKFDKGEQEGGKAALVLGLCFISE
GAIPFAARDPMRVLPCCIAGGALTGALSMAFGAQLMAPHGGLFVLLIPGAIHPVLLYLVAIAAGTLLAGGLYAMLKRPDA
MVAKVA
>Mature_566_residues
MKTLLIIDSSLGQARGHLATLMLGAAAKKAGLSWVEKAADAELVIVAGSSAPADSTLNGKKVYVGDVEKAVRDPDGFLAQ
AIAQAAPYQAAATPEPTSVTGAKRSVAGPKRIVAITACPTGVAHTFMAAEAIESEAKKRGWWVKVETRGSVGAGNEITPE
EVAAADLVIVAADIEVDLNKFAGKPMYRTTTGLALKKTVQELDKALVEADVYQPKTSSSTASKKTETGGPYRHLLTGVSY
MLPMVVAGGLCIALSFVFGIEAFKEKGTLAAALMQIGGDSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSTGAGF
LGGIIAGFLAGYVAKAISTKLHLPQSMEALKPILIIPLVASLIVGLTMIYIVGTPVAKIMTGLTHWLESMGTANAVLLGA
ILGAMMCTDMGGPVNKAAYAFGVALLSSSVYAPMAAIMAAGMVPPLAMGLATLLARNKFDKGEQEGGKAALVLGLCFISE
GAIPFAARDPMRVLPCCIAGGALTGALSMAFGAQLMAPHGGLFVLLIPGAIHPVLLYLVAIAAGTLLAGGLYAMLKRPDA
MVAKVA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=561, Percent_Identity=77.3618538324421, Blast_Score=856, Evalue=0.0,
Organism=Escherichia coli, GI1786951, Length=433, Percent_Identity=36.4896073903002, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI87082348, Length=462, Percent_Identity=33.982683982684, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1790386, Length=306, Percent_Identity=44.1176470588235, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788729, Length=347, Percent_Identity=26.8011527377522, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790387, Length=88, Percent_Identity=55.6818181818182, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788730, Length=88, Percent_Identity=38.6363636363636, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=43.0769230769231, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 57818; Mature: 57818

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLIIDSSLGQARGHLATLMLGAAAKKAGLSWVEKAADAELVIVAGSSAPADSTLNGK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
KVYVGDVEKAVRDPDGFLAQAIAQAAPYQAAATPEPTSVTGAKRSVAGPKRIVAITACPT
EEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GVAHTFMAAEAIESEAKKRGWWVKVETRGSVGAGNEITPEEVAAADLVIVAADIEVDLNK
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHCEEEEEECCEEEHHH
FAGKPMYRTTTGLALKKTVQELDKALVEADVYQPKTSSSTASKKTETGGPYRHLLTGVSY
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
MLPMVVAGGLCIALSFVFGIEAFKEKGTLAAALMQIGGDSAFALMVPVLAGFIAFSIADR
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PGLTPGLIGGMLAVSTGAGFLGGIIAGFLAGYVAKAISTKLHLPQSMEALKPILIIPLVA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLIVGLTMIYIVGTPVAKIMTGLTHWLESMGTANAVLLGAILGAMMCTDMGGPVNKAAYA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FGVALLSSSVYAPMAAIMAAGMVPPLAMGLATLLARNKFDKGEQEGGKAALVLGLCFISE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHC
GAIPFAARDPMRVLPCCIAGGALTGALSMAFGAQLMAPHGGLFVLLIPGAIHPVLLYLVA
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCHHCCCCCCEEEEECCCHHHHHHHHHHH
IAAGTLLAGGLYAMLKRPDAMVAKVA
HHHHHHHHHHHHHHHCCCCHHHEECC
>Mature Secondary Structure
MKTLLIIDSSLGQARGHLATLMLGAAAKKAGLSWVEKAADAELVIVAGSSAPADSTLNGK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
KVYVGDVEKAVRDPDGFLAQAIAQAAPYQAAATPEPTSVTGAKRSVAGPKRIVAITACPT
EEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GVAHTFMAAEAIESEAKKRGWWVKVETRGSVGAGNEITPEEVAAADLVIVAADIEVDLNK
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHCEEEEEECCEEEHHH
FAGKPMYRTTTGLALKKTVQELDKALVEADVYQPKTSSSTASKKTETGGPYRHLLTGVSY
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
MLPMVVAGGLCIALSFVFGIEAFKEKGTLAAALMQIGGDSAFALMVPVLAGFIAFSIADR
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PGLTPGLIGGMLAVSTGAGFLGGIIAGFLAGYVAKAISTKLHLPQSMEALKPILIIPLVA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLIVGLTMIYIVGTPVAKIMTGLTHWLESMGTANAVLLGAILGAMMCTDMGGPVNKAAYA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FGVALLSSSVYAPMAAIMAAGMVPPLAMGLATLLARNKFDKGEQEGGKAALVLGLCFISE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHC
GAIPFAARDPMRVLPCCIAGGALTGALSMAFGAQLMAPHGGLFVLLIPGAIHPVLLYLVA
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCHHCCCCCCEEEEECCCHHHHHHHHHHH
IAAGTLLAGGLYAMLKRPDAMVAKVA
HHHHHHHHHHHHHHHCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]