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The map label for this gene is ddc [H]

Identifier: 170024772

GI number: 170024772

Start: 2791691

End: 2793238

Strand: Reverse

Name: ddc [H]

Synonym: YPK_2547

Alternate gene names: 170024772

Gene position: 2793238-2791691 (Counterclockwise)

Preceding gene: 170024773

Following gene: 170024771

Centisome position: 59.56

GC content: 42.51

Gene sequence:

>1548_bases
ATGTACAAAGATATCTATGAGGAAAACCATTTTATAGATCAAGGTAATGATATAACTGATGTGCTTTGTTTAGGAAACTT
CTTAAATAAAGATAGCGCTGAACACTATTATGAGAGCGTGAATAATATCACTGCAAGGATTAAGGCTATATTCACCCTAG
TAGATAAACCTTTTAGCGGGATATTACCCTCTGAACTATCACCTGATTTTTATTGTATTGATTTAAATCAGCCACTAACG
TCATTGGATAGCGCATTAGATGAATTACAGCAGCTATATATTAAGGATGCTATATACTTTCATCACCCTAAATATGTTGC
GCATCTTAATTGCCCGGTTGTTCTCCCTGCAGTTCTGGCAGAAAGCATTATTAGTACCCTTAATTCTTCGTTGGATACCT
GGGATCAAAGTGCCGGTGCGACCTTAATTGAGCAGAAAGTTCTGGATTGGACCCGCGATAAAATGGCCCTAGGTAGCCAG
GGCGACGGTATTTTCACCAGCGGTGGAACACAGTCAAATCTTATGGCGATACTGCTGGCCCGTGATCATTTTTGCCACCA
ACGTGATGCTAACCACCAGAATAAATTGCAGGGATTACCCGCTGATTCTCATAAATTTCGTATCTTTACTTCGGTGGTTA
GCCATTTCAGTACACAAAAAGCCGCAGCACTATTGGGCCTTGGCTATAACGCGGTTGTTGCCGTGCCCTATGACAGTGAA
TTCAAGATGGATGCGCAGGCATTGGATCAAAGCATTGCGCTCTGTTTATCACAAGGCAATATTCCCTTAGCCATTGTTGC
TACCACCGGAACGACTGACTTTGGCAGTATTGACCCCTTGCACACTATTTCGACGTTGGCCAAACAGTACGGTCTTTGGT
TACATGTGGATGCTGCCTACGGCTGTGGCCTATTAGTTTCCTCACACTATGAACAGCTACTTTCCGGTATTGAAATGGCT
GATTCTGTGACGGTGGATTATCACAAGTCCTTTTTTCAACCGGTAAGTTGCAGTGCTTTTTTTGTTAAAGATAAACAGCA
TTTTTCTTATCTGACTTATCACGTGGAATACCTCAATCCATTAAGTGCATCACTGGAAGGTACGCCGAATTTAGTGAACA
AAAGTATTCAGACCACCCGTCGCTTTGATGCGCTAAAGCTGTGGTTAACGCTACGGATTATGGGAGCCAAACAGCTTGGT
TTGGCTTTTGAACATGTTATGGATACGGCACAGCAGGCTTATCAACTTATGTTGCCTAATCCGTATTTTGAACTAATACA
TCGCCCGGTATTAAGCACGCTGGTATTTCGTTTTATGCCGGAACAGCCTCGCAGCGATGACGATATTGATCGAACCAATG
CCTATATTCGCAAAGCGTTATTCCGTGAGGGGCATACGGTTATTGCAGGTACCAAAGTAAATGGTAAACAGTATTTGAAA
TTTACCTTCCTTAATCCGACGACCACACTCCAGCACCTGAACGAAATTGTGGATGCCATTATTACCGAGGGTAAAAACTA
TCCGACTCTCTATAACAGTCAATCATGA

Upstream 100 bases:

>100_bases
GCATTTATATCTACGTCTTATATTTACCTACAGTTAATTATAATAAAAAATATAATAAATATAGCGTCACTAAATGCCAC
TTTATATTTAAGGATATATT

Downstream 100 bases:

>100_bases
GATTGATGTTGTTTGATCAGGAGTAATTAGAACAATGCGACCTTATGACTTTATTGGCATCGGTATTGGCCCGTTTAACC
TCGGGCTAGCATGTTTAACC

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHVEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS

Sequences:

>Translated_515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHVEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
>Mature_515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHVEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=431, Percent_Identity=28.7703016241299, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4503875, Length=431, Percent_Identity=28.7703016241299, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI194294551, Length=431, Percent_Identity=29.9303944315545, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI197383062, Length=429, Percent_Identity=28.2051282051282, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI58331246, Length=426, Percent_Identity=28.169014084507, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI92110055, Length=439, Percent_Identity=25.5125284738041, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4503281, Length=406, Percent_Identity=24.6305418719212, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI132814448, Length=406, Percent_Identity=24.6305418719212, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71993062, Length=418, Percent_Identity=27.9904306220096, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17555682, Length=418, Percent_Identity=27.9904306220096, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71993058, Length=344, Percent_Identity=31.1046511627907, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534819, Length=435, Percent_Identity=22.9885057471264, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17534817, Length=435, Percent_Identity=22.7586206896552, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI133931025, Length=446, Percent_Identity=22.6457399103139, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17551992, Length=482, Percent_Identity=24.0663900414938, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71981211, Length=505, Percent_Identity=22.7722772277228, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71981217, Length=514, Percent_Identity=21.7898832684825, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17136594, Length=417, Percent_Identity=30.6954436450839, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24657193, Length=383, Percent_Identity=31.5926892950392, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24657185, Length=383, Percent_Identity=31.5926892950392, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24657188, Length=383, Percent_Identity=31.5926892950392, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356415, Length=387, Percent_Identity=27.906976744186, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17136190, Length=402, Percent_Identity=25.3731343283582, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24652373, Length=415, Percent_Identity=26.0240963855422, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585135, Length=415, Percent_Identity=24.8192771084337, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585139, Length=416, Percent_Identity=25, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI221476190, Length=416, Percent_Identity=25, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24585143, Length=416, Percent_Identity=25, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24586044, Length=433, Percent_Identity=22.8637413394919, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28573972, Length=442, Percent_Identity=24.2081447963801, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 57659; Mature: 57659

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILPSELSPDFYCIDLNQPLTSLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLA
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHH
ESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQGDGIFTSGGTQSNLMAILLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHEEEEEH
RDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAY
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GCGLLVSSHYEQLLSGIEMADSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHVEYLNP
CCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCEEEEEECCCHHEEEEEEHHHHCC
LSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLGLAFEHVMDTAQQAYQLMLPN
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILPSELSPDFYCIDLNQPLTSLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLA
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHH
ESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQGDGIFTSGGTQSNLMAILLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHEEEEEH
RDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAY
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GCGLLVSSHYEQLLSGIEMADSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHVEYLNP
CCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCEEEEEECCCHHEEEEEEHHHHCC
LSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLGLAFEHVMDTAQQAYQLMLPN
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]