Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 170024750

GI number: 170024750

Start: 2766762

End: 2767661

Strand: Direct

Name: hisG [H]

Synonym: YPK_2525

Alternate gene names: 170024750

Gene position: 2766762-2767661 (Clockwise)

Preceding gene: 170024748

Following gene: 170024751

Centisome position: 59.0

GC content: 51.56

Gene sequence:

>900_bases
ATGCTGGATAAAACACGTTTACGTATCGCGATGCAGAAATCGGGTCGCCTGAGTGATGAATCCCAAGAGTTGTTGTCCCG
CTGCGGGATTAAAATCAACCTGCAACAGCAGCGCCTGATAGCCTTCGCAGAGAACATGCCCATCGATATTCTGCGGGTCC
GTGATGACGATATCCCCGGTTTGGTGATGGATGGTGTGGTCGATCTGGGTATTATCGGCGAGAACGTGCTGGAAGAAGAG
TTACTTAATCGCCGCGCTCAAGGCGACGACCCTCGCTATTTCACCCTACGTCGCCTGGATTTTGGTGGCTGCCGCCTTTC
ACTGGCCGCCCCACTGGATGCTGAATACACTGGGCCGCAATGCCTGCAAGATACGCGTATCGCCACCTCTTATCCGCACA
TTTTAAAACAGTATCTCGATAAACAAGGCGTTCGTTTTAAATCCTGTTTATTGAATGGTTCTGTTGAAGTAGCCCCGCGT
GCTGGTTTGGCCGATGCCATCTGTGATTTGGTATCCACCGGTGCCACGCTGGAAGCCAATGGTCTGCGTGAAGTTGAAGT
GATCTACCGCTCAAAAGCCTGCCTGATCCAACGTGATGGTGAAATGTCCGTTGATAAACAGCAACTGATTGATCGCCTGA
TGACCCGTATTCAAGGGGTGATCCAAGCGCGTGAATCCAAGTACATCATGATGCACGCGCCGAGCGAACGTCTGGACGAA
ATCATTACTCTGTTACCAGGGGCTGAACGCCCAACCATTCTGCCACTGGCCGGTGACAAGAGCCGTGTTGCCATGCACAT
GGTCAGCAGCGAAACGTTGTTCTGGGAAACCATGGAGAAATTGAAGGCGCTGGGTGCCAGCTCCATTCTGGTATTACCGA
TTGAAAAAATGATGGAGTAA

Upstream 100 bases:

>100_bases
CAATGAGTCAATGAGTCAGTAAGTTGGGCGAGTGAATGTAGCTAACAACCCTGCGACGTCAAGGACGAAGGGGATAAATT
AATAAATTAAGAGGATTACC

Downstream 100 bases:

>100_bases
CCCATGCAGCCGACGAATTTCAATACCCTGATCAATTGGCAACAATGCAGTGAAGAACAGCAAAAAGCGCTGTTGAGCCG
CCCGGCCATCAATGCATCCG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQCLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDE
IITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQCLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDE
IITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
>Mature_299_residues
MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEE
LLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQCLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDE
IITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=87.9598662207358, Blast_Score=540, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320896, Length=299, Percent_Identity=30.4347826086957, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33456; Mature: 33456

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPG
CCCCHHEEEEECCCCCCCCHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEELLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQ
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHH
CLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
HHHCCCCCCCCHHHHHHHHHHCCCEEEHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDE
CCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
IITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
HHHHCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPG
CCCCHHEEEEECCCCCCCCHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEELLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQ
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHH
CLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
HHHCCCCCCCCHHHHHHHHHHCCCEEEHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDE
CCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
IITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
HHHHCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA