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The map label for this gene is hisD

Identifier: 170024751

GI number: 170024751

Start: 2767665

End: 2768996

Strand: Direct

Name: hisD

Synonym: YPK_2526

Alternate gene names: 170024751

Gene position: 2767665-2768996 (Clockwise)

Preceding gene: 170024750

Following gene: 170024752

Centisome position: 59.02

GC content: 53.45

Gene sequence:

>1332_bases
ATGCAGCCGACGAATTTCAATACCCTGATCAATTGGCAACAATGCAGTGAAGAACAGCAAAAAGCGCTGTTGAGCCGCCC
GGCCATCAATGCATCCGAGAGGATCACTGCGGCGGTCAGTGACATCCTGGACCGGGTGAAAGCGGAAGGCGATAGCGCCC
TGCGTGATTTTAGCCAGCGTTTTGACCATGTGCAGGTCGCGGATATCCGTATCACTGCATCAGAGATCGCTGCGGCCTCG
GCGCGCCTGAGTGACGATGTCAAGCACGCCATGGCACAGGCGGTACGTAATATTGAAATCTTCCACAACGCGCAGAAAAT
GCCGGTGGTGGATGTTGAAACTCAGCCGGGTGTGCGTTGTCAGCAAATCACGCGTCCGATTGCTTCCGTCGGCTTGTATA
TTCCCGGTGGTTCTGCACCGTTGCCATCAACCGTACTGATGCTCGGCACCCCAGCACGTATTGCCGGTTGTCAGCGGGTC
GTTTTATGTTCTCCACCGCCTATTGCCGATGAAATTTTGTATGCCGCTCAACTGTGCGGTATTCAGGAAGTATTCCAGAT
CGGCGGGGCACAAGCGATCGCCGCCATGGCATTCGGCAGTGAATCAGTACCTAAAGTGCACAAAATTTTTGGGCCGGGCA
ACGCTTATGTCACTGAAGCAAAACGTCAGGTTAGCCAGCGCCTGGACGGTGCTGCCATCGATATGCCCGCAGGCCCATCA
GAGGTGTTGGTGATCGCCGACAGCGGTGCTACACCTGCGTTTATCGCGGCGGATTTACTCTCACAAGCGGAACACGGGCC
TGATTCTCAAGTGATCTTACTGACACCTGATGCCGCTATCGCACAAGCGGTGGCAGTCGAAGTTGAGCAACAACTCGCGC
TGTTATCCCGAGCCGATATTGCCCGTCAGGCACTGGAAAGCAGCCGTTTGATCGTGACCAACGATTTACAGCAATGCATT
GATATCAGTAATGCATACGGCCCTGAGCATTTGATTCTACAAATTCGTCAACCAGAAGAAATCATTGACCAGATTGATAA
CGCTGGCTCCGTGTTTATGGGCGATTGGTCACCGGAATCGGCTGGGGATTACGCCTCGGGCACCAACCACGTACTGCCAA
CCTACGGTTATACCTCAACCTATTCCAGTTTAGGTTTGGCTGACTTTGTTAAGCGTATGACCGTACAGCAATTGACACCA
CAGGGTTTGTTAGGGCTGGCCTCCACCATCGAAACACTGGCACAGGCCGAACAACTGACCGCACACAAAAATGCAGTTAC
CCTGCGCGTTACCGCCTTGAATAACGCCCTGACCGCCGTGAATAAGGAGTAA

Upstream 100 bases:

>100_bases
CAGCAGCGAAACGTTGTTCTGGGAAACCATGGAGAAATTGAAGGCGCTGGGTGCCAGCTCCATTCTGGTATTACCGATTG
AAAAAATGATGGAGTAACCC

Downstream 100 bases:

>100_bases
GCATGAGCCAATCTAATAACGTCACGGACCTGGCCCGTGCCAACATCCGTGCTCTGACTCCCTATATGTCCGCACGTCGG
TTAGGCGGTAATGGCGATGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITAAVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE

Sequences:

>Translated_443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITAAVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE
>Mature_443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITAAVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=430, Percent_Identity=75.8139534883721, Blast_Score=681, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=45.0471698113208, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_YERPE (Q8ZFX5)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0188
- RefSeq:   NP_669924.1
- RefSeq:   NP_992801.1
- RefSeq:   YP_002346564.1
- ProteinModelPortal:   Q8ZFX5
- SMR:   Q8ZFX5
- IntAct:   Q8ZFX5
- GeneID:   1147568
- GeneID:   1174387
- GeneID:   2765680
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1548
- KEGG:   ypk:y2621
- KEGG:   ypm:YP_1437
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   YPES187410:Y2621-MONOMER
- BioCyc:   YPES214092:YPO1548-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47233; Mature: 47233

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 329-329 ACT_SITE 330-330 BINDING 133-133 BINDING 191-191 BINDING 214-214 BINDING 240-240 BINDING 262-262 BINDING 265-265 BINDING 330-330 BINDING 363-363 BINDING 417-417 BINDING 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITAAVSDILDRVKAEGDSALRDFSQR
CCCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FDHVQVADIRITASEIAAASARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRC
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
QQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRVVLCSPPPIADEILYAAQLCG
HHHHHHHHHCEEECCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
IQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
HHHHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARQALESSRLIVTNDLQQCIDISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPES
HHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCC
AGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTPQGLLGLASTIETLAQAEQLT
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AHKNAVTLRVTALNNALTAVNKE
HCCCEEEEEEEECCCHHHHCCCC
>Mature Secondary Structure
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITAAVSDILDRVKAEGDSALRDFSQR
CCCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FDHVQVADIRITASEIAAASARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRC
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
QQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRVVLCSPPPIADEILYAAQLCG
HHHHHHHHHCEEECCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
IQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
HHHHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARQALESSRLIVTNDLQQCIDISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPES
HHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCC
AGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTPQGLLGLASTIETLAQAEQLT
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AHKNAVTLRVTALNNALTAVNKE
HCCCEEEEEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430