Click here to switch to the map view.

The map label for this gene is lldD

Identifier: 170024731

GI number: 170024731

Start: 2741665

End: 2742810

Strand: Reverse

Name: lldD

Synonym: YPK_2506

Alternate gene names: 170024731

Gene position: 2742810-2741665 (Counterclockwise)

Preceding gene: 170024732

Following gene: 170024729

Centisome position: 58.49

GC content: 55.15

Gene sequence:

>1146_bases
ATGATCATTTCTGCCTCAACGGATTATCGTGCCGCCGCGCAGCGTAAATTGCCGCCGTTTCTTTTCCACTACATCGACGG
TGGTGCGTACAACGAACAAACTCTACGGCGCAATACCGCCGATTTGGCTGATATCGCCCTGCGCCAGCGTGTGCTGAAGA
ACATGTCTGAACTGAGTCTGGAAACGCAGCTTTTCGGCGAGACGCAGGCAATGCCTGTTGTCCTTGGGCCAGTCGGTCTG
AGCGGCATGTACGCACGGCGTGGTGAAGTGCAGGCCGCGCGGGCGGCGGATAAAAAAGGTATTCCTTTCACCCTCTCAAC
CCTTTCGGTTTGCCCTATCGAAGAGGTGGCTCCTGCCATTGCCCGGCCAATGTGGTTTCAGCTTTATGTCCTGAAAGATC
GGGGTTTTATGCGTAATGCACTGACGCGTGCACAGGCCGCTGGCGTGAAGACGTTGGTGTTTACCGTAGATATGCCGGTA
CCTGGCGCACGTTACCGCGATGCACACTCTGGTATGAGTGGGCCGAATGCTGCCGCTCGCCGCTTGCTTCAGGCGATAGC
CCACCCACAGTGGGCTTGGGATGTGGGCTTAAACGGCAAGCCCCATGACTTGGGGAATATATCGGCCTATCTCGGTAAGC
CAACCACGCTGGAGGATTATATGGGTTGGATAGCGACAAATTTCGACCCATCGATCTCGTGGAAAGATTTGGAGTGGGTA
CGTGAGTTCTGGCAAGGGCCGATGATCATTAAAGGTATTCTCGATCCGGAAGATGCCAAAGATGCAGTGAAATTTGGTGC
TGATGGCATTGTGGTGTCAAACCACGGCGGGCGTCAGCTTGACGGTGTGCTCTCCACCGCTCGTGCCTTGCCAGCCATTG
CAGATGCTGTCAAAGGGGATATCACTATTCTGGCTGATTCCGGCATCCGTACTGGGTTGGACGTCGTACGAATGATAGCG
CTCGGCGCGGATAGCGTGTTGTTAGGCCGTGCCTTCGTCTATGCTCTGGCCACCGCAGGAGAAGCCGGTGTTATCAATCT
GCTGACGCTGATCGAGCAAGAAATGCGTGTGGCGATGACGTTGACCGGAGCGAAGCGAATTGCCGATATCAACCGGGATT
CTTTGGCAGTAAGTGAACGGGGGTAA

Upstream 100 bases:

>100_bases
CAGTCAGTGACTGGGGTGAACGAAAGCCGCCAACACACCAGCAGCTTGAAATATAACGGGTATATTTTTATCAACCATAA
CACCATTATGGACCGTGAAG

Downstream 100 bases:

>100_bases
AAGAATAATAAATAAAAAGCGTTTCAGAGCCTGTATCGGGTGATGGCTGTCTGATGATTTGGCTGAATACCGGCCTGATT
TACTGTGACACGAGAAGGGT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSLETQLFGETQAMPVVLGPVGL
SGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAIARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWV
REFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGDITILADSGIRTGLDVVRMIA
LGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMTLTGAKRIADINRDSLAVSERG

Sequences:

>Translated_381_residues
MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSLETQLFGETQAMPVVLGPVGL
SGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAIARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWV
REFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGDITILADSGIRTGLDVVRMIA
LGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMTLTGAKRIADINRDSLAVSERG
>Mature_381_residues
MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSLETQLFGETQAMPVVLGPVGL
SGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAIARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWV
REFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGDITILADSGIRTGLDVVRMIA
LGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMTLTGAKRIADINRDSLAVSERG

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=383, Percent_Identity=35.7702349869452, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI54234014, Length=380, Percent_Identity=35.7894736842105, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI7705393, Length=380, Percent_Identity=35.7894736842105, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=83.2, Blast_Score=659, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=375, Percent_Identity=33.0666666666667, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.0422535211268, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=28.5340314136126, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI78707188, Length=371, Percent_Identity=34.2318059299191, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281363140, Length=372, Percent_Identity=34.1397849462366, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI78707190, Length=372, Percent_Identity=34.1397849462366, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_YERP3 (A7FJF0)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401378.1
- ProteinModelPortal:   A7FJF0
- SMR:   A7FJF0
- STRING:   A7FJF0
- GeneID:   5384779
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2409
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   NFDPSIG
- ProtClustDB:   PRK11197
- BioCyc:   YPSE349747:YPSIP31758_2409-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 41259; Mature: 41259

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSL
CEEECCCCHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
ETQLFGETQAMPVVLGPVGLSGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAI
HHHHHCCCCCCEEEEECCCCCCHHHCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
ARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPVPGARYRDAHSGMSGPNAAAR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWV
HHHHHHCCCCCEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
REFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGD
HHHHCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITILADSGIRTGLDVVRMIALGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHE
LTGAKRIADINRDSLAVSERG
ECCHHHHHHCCCCCEECCCCC
>Mature Secondary Structure
MIISASTDYRAAAQRKLPPFLFHYIDGGAYNEQTLRRNTADLADIALRQRVLKNMSELSL
CEEECCCCHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
ETQLFGETQAMPVVLGPVGLSGMYARRGEVQAARAADKKGIPFTLSTLSVCPIEEVAPAI
HHHHHCCCCCCEEEEECCCCCCHHHCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
ARPMWFQLYVLKDRGFMRNALTRAQAAGVKTLVFTVDMPVPGARYRDAHSGMSGPNAAAR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RLLQAIAHPQWAWDVGLNGKPHDLGNISAYLGKPTTLEDYMGWIATNFDPSISWKDLEWV
HHHHHHCCCCCEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
REFWQGPMIIKGILDPEDAKDAVKFGADGIVVSNHGGRQLDGVLSTARALPAIADAVKGD
HHHHCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITILADSGIRTGLDVVRMIALGADSVLLGRAFVYALATAGEAGVINLLTLIEQEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHE
LTGAKRIADINRDSLAVSERG
ECCHHHHHHCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA