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The map label for this gene is uhpA [H]

Identifier: 170024724

GI number: 170024724

Start: 2732670

End: 2733299

Strand: Direct

Name: uhpA [H]

Synonym: YPK_2499

Alternate gene names: 170024724

Gene position: 2732670-2733299 (Clockwise)

Preceding gene: 170024723

Following gene: 170024727

Centisome position: 58.27

GC content: 48.73

Gene sequence:

>630_bases
ATGATTAATGTTGCATTGATTGACGACCATATTGTCGTCCGTTCTGGTTTTGCTCAATTACTGTCACTGGAAGAAGATAT
ACGTATTATTGGCGAATACGGTTGTGCGGCCGAGGCATGGGAAAATCTGCCCAAAACGGATGTACATGTGGCGGTAATAG
ATATTTCAATGCCGGATGAGAGTGGGCTAAGCCTGCTCAAGCGCCTGCGCCAACAGATACCGCATTTTCGCGCCATTATT
CTGAGTATTTATGACACAACCGCCTTTGTGCAGAGTGCAATGGACGCCGGAGCCAGTGGCTACCTGACCAAACGCTGTGA
TCCAGCGGCATTGGTACAGGCACTGCGCACCGTCAATGGCGGCGGCCTTTATCTGTGTACCGATGCGCTACGGGCGCTAC
GCCAAATGCCTCAACAGCCGAGTAAGCTGACAATTTTAACTCCGCGAGAAAAAGAGATTTTTCAATTATTGGTCAAAGGG
ATAAGTGTAAAAGCCCTTGCCGAACAGTTGTCGCTCAGCCATAAAACCGTTCATGTCCATCGGGCCAATATTCTGAGTAA
ACTCAATTGTGAAACCACCATTGAACTGGTGCACTTCGCACTACAGCATCAGCTACTGGCGGGTAACTGA

Upstream 100 bases:

>100_bases
TCCCATAGATGCTAAGCCCATTATATTTTTGATAACAACCATTGCTCCGCGATAAAGAGATGAGCATCATGCTGTTTCTC
TCCCCCAATAATTAGAAATC

Downstream 100 bases:

>100_bases
TATGGCGTAATTGCGGTCAGTTGGCTTATGGCGTATTGAAGTCGGGCAAACCATTTGCGGCCTAAATACCGCTTGCCGAT
AGTTGGCAAGACGGTATTTA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MINVALIDDHIVVRSGFAQLLSLEEDIRIIGEYGCAAEAWENLPKTDVHVAVIDISMPDESGLSLLKRLRQQIPHFRAII
LSIYDTTAFVQSAMDAGASGYLTKRCDPAALVQALRTVNGGGLYLCTDALRALRQMPQQPSKLTILTPREKEIFQLLVKG
ISVKALAEQLSLSHKTVHVHRANILSKLNCETTIELVHFALQHQLLAGN

Sequences:

>Translated_209_residues
MINVALIDDHIVVRSGFAQLLSLEEDIRIIGEYGCAAEAWENLPKTDVHVAVIDISMPDESGLSLLKRLRQQIPHFRAII
LSIYDTTAFVQSAMDAGASGYLTKRCDPAALVQALRTVNGGGLYLCTDALRALRQMPQQPSKLTILTPREKEIFQLLVKG
ISVKALAEQLSLSHKTVHVHRANILSKLNCETTIELVHFALQHQLLAGN
>Mature_209_residues
MINVALIDDHIVVRSGFAQLLSLEEDIRIIGEYGCAAEAWENLPKTDVHVAVIDISMPDESGLSLLKRLRQQIPHFRAII
LSIYDTTAFVQSAMDAGASGYLTKRCDPAALVQALRTVNGGGLYLCTDALRALRQMPQQPSKLTILTPREKEIFQLLVKG
ISVKALAEQLSLSHKTVHVHRANILSKLNCETTIELVHFALQHQLLAGN

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=47.9591836734694, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=35.4066985645933, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1788521, Length=204, Percent_Identity=32.843137254902, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=27.8606965174129, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=32.0652173913043, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788712, Length=204, Percent_Identity=24.0196078431373, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23043; Mature: 23043

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVALIDDHIVVRSGFAQLLSLEEDIRIIGEYGCAAEAWENLPKTDVHVAVIDISMPDE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEECCCH
SGLSLLKRLRQQIPHFRAIILSIYDTTAFVQSAMDAGASGYLTKRCDPAALVQALRTVNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
GGLYLCTDALRALRQMPQQPSKLTILTPREKEIFQLLVKGISVKALAEQLSLSHKTVHVH
CCEEEHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCHHEEEEH
RANILSKLNCETTIELVHFALQHQLLAGN
HHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINVALIDDHIVVRSGFAQLLSLEEDIRIIGEYGCAAEAWENLPKTDVHVAVIDISMPDE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEECCCH
SGLSLLKRLRQQIPHFRAIILSIYDTTAFVQSAMDAGASGYLTKRCDPAALVQALRTVNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
GGLYLCTDALRALRQMPQQPSKLTILTPREKEIFQLLVKGISVKALAEQLSLSHKTVHVH
CCEEEHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCHHEEEEH
RANILSKLNCETTIELVHFALQHQLLAGN
HHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]