Click here to switch to the map view.

The map label for this gene is alsR [H]

Identifier: 170024492

GI number: 170024492

Start: 2515021

End: 2515899

Strand: Reverse

Name: alsR [H]

Synonym: YPK_2265

Alternate gene names: 170024492

Gene position: 2515899-2515021 (Counterclockwise)

Preceding gene: 170024502

Following gene: 170024488

Centisome position: 53.65

GC content: 51.08

Gene sequence:

>879_bases
ATGGAGTTACGTCATATACGCTATTTTCTGGCTGTTGCTGAAGAACGACATTTCACACGCGCTGCCGCCCGGCTAGGAAT
AGGGCAGCCTCCTCTCAGTCAGCAAATTAAGGATCTGGAGAGGGAACTCGGTGCGTTGTTGTTCCGGCGGGTTTCTTATG
GCGCAGAATTAACTGAGGCAGGTATTGCATTTCTGGATGTTGTCAAAGAGATACCTGTGATGGCAGAAAGAGCGACCCAA
GCTGCGCAGCGGGCTGTCAGGGGAGAACTCGGCGTACTCAGAGTTGGCTTTACTGCGTCATCAGCATTTAACAGCGTAGT
GCCTACGGCGATCCGTGCCTTTAGACGTGCATATCCTGATGTACGATTACAGCTAGAGGAAGATAACACGACTCGACTGG
CTGATGGATTGAATGAAGGCTCGCTCGATGTCGCTTTCCTGAGGCCAGGCTTTGCTGGCAGCGAACGTTTCCACCTCAGA
ATGCTATCTGAAGAGCCGATGATGATTGTCATGGCGGAAAATCACCCGGCGGCATCGTATGAAGAAATTTCGCTTAGCGC
ATTCAGGGATGAAACTTTCCTGCTATTTCCACGAGAGATTGGTCTGACGCTTTACGATTCAGTGATTGAGTCATGCCGTA
CTGCGGGTTTTGAGCCGACTATTGGCCAACTGGCACCACAAATCGCTTCGGTCATTAATCTCGTTGCGGCAGAAATGGGC
GTTTCAATCGTTCCGGCTTCCATGAGCCAAGTGAAAGTTATTGGGGTTGTATATCGACACATTGCTGACCAGACGCCGAC
AGCAAAGCTCGCGTTGGCGTACCGGCGAGGGGATACCTCGCCGGTATTAAGAAACTTTGTCCTGACCGTGTTTCCTTGA

Upstream 100 bases:

>100_bases
AGACATGATGTTCCTCCTCCAACTTCGCTTAGTCTATGGTCGCCGTTATCATTTATCCAATATATGATACCGGTGTGTTT
AATTGCTTTTGGATATGAAG

Downstream 100 bases:

>100_bases
ATTCTCTCCGTAGGTTAAGGCGACTCAATAGGTTAAAACGATCCAATCGGTTAAAAAACGCCCCAAGAGCAAAATTATTG
GCTATCAATATCCGGCCTGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERATQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Sequences:

>Translated_292_residues
MELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERATQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
>Mature_292_residues
MELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERATQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=40.418118466899, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=34.1379310344828, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI2367136, Length=282, Percent_Identity=31.2056737588652, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=31.8021201413428, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI157672245, Length=250, Percent_Identity=32.4, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787601, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081904, Length=189, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789173, Length=138, Percent_Identity=38.4057971014493, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=24.3027888446215, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082132, Length=298, Percent_Identity=25.1677852348993, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787589, Length=174, Percent_Identity=29.8850574712644, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32223; Mature: 32223

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GIAFLDVVKEIPVMAERATQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
VRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAASY
EEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCCH
EEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
HHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
CEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC
>Mature Secondary Structure
MELRHIRYFLAVAEERHFTRAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GIAFLDVVKEIPVMAERATQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
VRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAASY
EEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCCH
EEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
HHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
CEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]