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The map label for this gene is aaeR [H]

Identifier: 170024338

GI number: 170024338

Start: 2333087

End: 2333992

Strand: Reverse

Name: aaeR [H]

Synonym: YPK_2104

Alternate gene names: 170024338

Gene position: 2333992-2333087 (Counterclockwise)

Preceding gene: 170024341

Following gene: 170024333

Centisome position: 49.77

GC content: 53.75

Gene sequence:

>906_bases
ATGCACGATCTCAATGATCTCTACTACTACGCAGAAGTTGTAGAACATGGCGGGTTCAGCGCCGCTGCACGGGTGTTGGG
CTTGCCTAAGTCCAAGCTAAGCCGCCGATTGGCTCTGCTTGAGGAACGTCTGGGGGTGCGGCTCATTCAACGCTCAACCC
GGCGCTTTGCTGTCACTGATGTTGGCCGTACCTATTACGAGCATTGTAAAGCGATGATCGAAGAGGCAAGAGCGGCGCAG
GAGTCTATTGATTTAACACGTGCGGAACCACGCGGTGTGGTGCGAATCACCTGCCCGGTGGCGCTGTTGCAGGCGACGGT
CAGTACCATGCTGGCGGATTTTATGGCCAGTTGTCCTCTGGTGACGATTCATCTGGAAGCGACTAACCGGCAGGTTGATC
CCGTTGCTGAGGCCATTGATATTGCGATTCGCGTGCGGCCACCGCCATTACAAAATAGCGATTTAGTGCTGCGGGTTCTG
GGTAATCGCTGCCAGTGTTTGGTCGCTAGCCCTGAGTTGATAGGGCGACAGGGTGAAGTAAATACTCCAGTTGATCTAAC
CGGTTGGCCAAGCCTTGGGTTAGGGCAACCTCAGCAAACGTTTATTTGGAACTTAGAAGGGCCGGAGAAGGCTCATGCAG
CGGTGTATCATCAGCCGCGGTTGGTGACAGCAGATATGAATACCTTACGCAGTGCGGCATTGGCCGGTGTAGGGGTAGTA
CAATTGCCACTGATGATGGTGACGGAACAACTGGCCGAAGGCACATTAGTTCGCCTATTGCCTGATTGGTCAGTCCGCCA
TGAGATTATTCATGCGGTCTATCCTTCAAGGCGCGGGTTGCTACCTTCGGTACGCAGCGTATTGGATTATCTTGTTCAGC
GCTTCAGCCAATTGGATGAACGGTGA

Upstream 100 bases:

>100_bases
TTTTAGGATAATGTGAGCGGTAGTCGGCAAAATTAACTCTCACTGTTCCACAAATAGAACAATACTTGTCGAATTGCTTA
TTATAAAGAGAGAGGCGGAT

Downstream 100 bases:

>100_bases
GAGTTTGGTGTTTATACCGCTAACGTTTGCACCGCTAGTGCTTATGTTGATGATACTTATGTTGATTATGCTTATGTCGA
GGATGTTTATGCTGATGGTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MHDLNDLYYYAEVVEHGGFSAAARVLGLPKSKLSRRLALLEERLGVRLIQRSTRRFAVTDVGRTYYEHCKAMIEEARAAQ
ESIDLTRAEPRGVVRITCPVALLQATVSTMLADFMASCPLVTIHLEATNRQVDPVAEAIDIAIRVRPPPLQNSDLVLRVL
GNRCQCLVASPELIGRQGEVNTPVDLTGWPSLGLGQPQQTFIWNLEGPEKAHAAVYHQPRLVTADMNTLRSAALAGVGVV
QLPLMMVTEQLAEGTLVRLLPDWSVRHEIIHAVYPSRRGLLPSVRSVLDYLVQRFSQLDER

Sequences:

>Translated_301_residues
MHDLNDLYYYAEVVEHGGFSAAARVLGLPKSKLSRRLALLEERLGVRLIQRSTRRFAVTDVGRTYYEHCKAMIEEARAAQ
ESIDLTRAEPRGVVRITCPVALLQATVSTMLADFMASCPLVTIHLEATNRQVDPVAEAIDIAIRVRPPPLQNSDLVLRVL
GNRCQCLVASPELIGRQGEVNTPVDLTGWPSLGLGQPQQTFIWNLEGPEKAHAAVYHQPRLVTADMNTLRSAALAGVGVV
QLPLMMVTEQLAEGTLVRLLPDWSVRHEIIHAVYPSRRGLLPSVRSVLDYLVQRFSQLDER
>Mature_301_residues
MHDLNDLYYYAEVVEHGGFSAAARVLGLPKSKLSRRLALLEERLGVRLIQRSTRRFAVTDVGRTYYEHCKAMIEEARAAQ
ESIDLTRAEPRGVVRITCPVALLQATVSTMLADFMASCPLVTIHLEATNRQVDPVAEAIDIAIRVRPPPLQNSDLVLRVL
GNRCQCLVASPELIGRQGEVNTPVDLTGWPSLGLGQPQQTFIWNLEGPEKAHAAVYHQPRLVTADMNTLRSAALAGVGVV
QLPLMMVTEQLAEGTLVRLLPDWSVRHEIIHAVYPSRRGLLPSVRSVLDYLVQRFSQLDER

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=302, Percent_Identity=30.4635761589404, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786401, Length=290, Percent_Identity=31.0344827586207, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87081978, Length=295, Percent_Identity=29.8305084745763, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=27.9461279461279, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787128, Length=291, Percent_Identity=25.085910652921, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789440, Length=308, Percent_Identity=26.9480519480519, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787589, Length=279, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788706, Length=270, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI157672245, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787601, Length=116, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789173, Length=267, Percent_Identity=24.3445692883895, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33453; Mature: 33453

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50931 HTH_LYSR ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLNDLYYYAEVVEHGGFSAAARVLGLPKSKLSRRLALLEERLGVRLIQRSTRRFAVTD
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHH
VGRTYYEHCKAMIEEARAAQESIDLTRAEPRGVVRITCPVALLQATVSTMLADFMASCPL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCE
VTIHLEATNRQVDPVAEAIDIAIRVRPPPLQNSDLVLRVLGNRCQCLVASPELIGRQGEV
EEEEEECCCCCCHHHHHHHEEEEEECCCCCCCCCHHHEECCCCCEEEEECHHHHCCCCCC
NTPVDLTGWPSLGLGQPQQTFIWNLEGPEKAHAAVYHQPRLVTADMNTLRSAALAGVGVV
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHCCHHH
QLPLMMVTEQLAEGTLVRLLPDWSVRHEIIHAVYPSRRGLLPSVRSVLDYLVQRFSQLDE
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure
MHDLNDLYYYAEVVEHGGFSAAARVLGLPKSKLSRRLALLEERLGVRLIQRSTRRFAVTD
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHH
VGRTYYEHCKAMIEEARAAQESIDLTRAEPRGVVRITCPVALLQATVSTMLADFMASCPL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCE
VTIHLEATNRQVDPVAEAIDIAIRVRPPPLQNSDLVLRVLGNRCQCLVASPELIGRQGEV
EEEEEECCCCCCHHHHHHHEEEEEECCCCCCCCCHHHEECCCCCEEEEECHHHHCCCCCC
NTPVDLTGWPSLGLGQPQQTFIWNLEGPEKAHAAVYHQPRLVTADMNTLRSAALAGVGVV
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHCCHHH
QLPLMMVTEQLAEGTLVRLLPDWSVRHEIIHAVYPSRRGLLPSVRSVLDYLVQRFSQLDE
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]