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The map label for this gene is sapA [H]

Identifier: 170024131

GI number: 170024131

Start: 2098412

End: 2100055

Strand: Reverse

Name: sapA [H]

Synonym: YPK_1892

Alternate gene names: 170024131

Gene position: 2100055-2098412 (Counterclockwise)

Preceding gene: 170024132

Following gene: 170024130

Centisome position: 44.78

GC content: 49.03

Gene sequence:

>1644_bases
ATGCGTGGTTTACTGATTTTGCTGTTGTCGCTGATTTGCCTTGCAACCCCTGTGCTGGCACAACCTGTTGCAGCGGAGCA
ACCGCTACCGGATATCCGTCAGCGCGGATTTGTCTATTGTGTCAGTGGGATACTCAACACATTTAACCCCCAAATGGCCA
GTAGCGGTTTAACCGTCGATACACTTGCAGCACAACTCTATGACCGCCTACTGGATGTTGACCCCTATACCTACCGGTTA
ATCCCAGAACTGGCGGAAAGTTGGCAAGTTCTGGATAACGGCGCAACCTACCGTTTTCATTTACGTAAAGATGTGCCATT
TCAGACTACCGACTGGTTTACGCCTACGCGGATGATGAACGCCGATGATGTGGTCTTCAGTTTTCAGCGAGTATTTGACT
CAAAGCATCCGTACCACAAGGTCAACGGCGGAGAGTACCCCTACTTTGATAGTTTGCAGTTTGCAAGCGCCGTAAAAAGC
GTAAAAAAATTGGATGATTACACCGTTGAATTTAAGCTAAAAGCCCCAGATGCGTCGTTTCTTTGGCATTTAGCAACTCA
TTACGCCCCCGTATTGTCTTCAGAATACGCCGATGTCCTGACCCAGAAAGGGAAGGAAGAACAGATTGACCGTGAGCCAG
TCGGGACCGGGCCTTTTCTATTGGATGAATATCGTTCTGGGCAATATATCCGCTTGTTCCGCAACAGCCACTATTGGAAA
GGTGTGCCACGTATGCCACAGGTGGTTATCGACTTAGGGGTCGGTGGAACGGGGCGTTTATCAAAACTGTTGACCGGAGA
GTGTGATGTGCTGGCCTATCCCGCCGCCAGCCAATTATCTATTTTACGTGATGACCCACGCCTACGCCTGACACTGCGCC
CAGGGATGAACGTCGCCTATCTCGCCTTCAATACCCGCAAGCCCCCGTTAAGTGATCAACGGGTTCGCCAAGCGATCGCT
TTGTCGATCAATAACCAACGATTGATGCAATCAATCTATTACGGCACAGCTGAAACGGCAGCCTCTATTTTACCTAGAGC
ATCATGGGCTTATGATAATCAGGCGCAGGTGACCGAATATAATCCGGAAAAAGCCAAAGAGATCCTCAAAGATTTGGGGA
TAACCCAACTGCAACTTAACTTATGGGTCCCTACTGCATCGCAATCTTATAATCCTAGCCCATTGAAAACTGCTGAATTG
ATCCAAGCGGATTTAGCACAAGTGGGGATTTCCGTCACTATTGTTCCCGTCGAGGGCCGTTTCCAAGAGGCCCGTCTGAT
GGAGATGAACCACGATCTGACACTTTCCGGTTGGTCTACTGACAGTAATGACCCCGACAGTTTCTTCCGGCCATTATTAA
GCTGTGCAGCAATTCGTTCGCAAACAAACTATGCTCACTGGTGTGATCCGGCCTTTGATGAATTACTGCAAAAGGCATTA
CGTTCCCAACAATTATCGGAGCGTATTGAGTATTATCAGCAGGCTCAGCGTATTCTGGAGCAACAATTGCCGTTACTGCC
ACTGGCATCGTCCCTGCGGCTTCAGGCATACCGTTATGACATTAAAGGCTTGGTATTAAGCCCGTTCGGTAACTCTTCTT
TCGCCGGTGTATACCGCGAAAGCGATGAGGGCAAGACGCCATGA

Upstream 100 bases:

>100_bases
GCAATCCCCTCAGATGAAACAGTTGTTTTGTGCAATGGATTGGGGGGATCGTCAGATTACGGTACACTAAGCGTATTGCT
TACTCACTGCGAAAGCGTTT

Downstream 100 bases:

>100_bases
TTATTTTCACATTACGGCGATTATTACTGCTCGTGATAACCCTGTTTATGTTGTCATTAGTCAGCTTTAGCCTGAGCTAT
TTTACCCCCTATGCACCGTT

Product: extracellular solute-binding protein

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAIA
LSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAEL
IQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKAL
RSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP

Sequences:

>Translated_547_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAIA
LSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAEL
IQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKAL
RSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP
>Mature_547_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAIA
LSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAEL
IQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKAL
RSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1787551, Length=544, Percent_Identity=76.2867647058823, Blast_Score=850, Evalue=0.0,
Organism=Escherichia coli, GI1789966, Length=536, Percent_Identity=38.4328358208955, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1787052, Length=513, Percent_Identity=26.5107212475634, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787762, Length=492, Percent_Identity=24.7967479674797, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1789397, Length=526, Percent_Identity=27.9467680608365, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1789887, Length=456, Percent_Identity=25, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1787495, Length=491, Percent_Identity=25.6619144602851, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081878, Length=454, Percent_Identity=25.3303964757709, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61802; Mature: 61802

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00027 HOMEOBOX_1 ; PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHH
TLAAQLYDRLLDVDPYTYRLIPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCC
ADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKSVKKLDDYTVEFKLKAPDASF
CHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHH
LWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNVAY
CCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHEEECCCCEEEEECCCCCEEE
LAFNTRKPPLSDQRVRQAIALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEY
EEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEECC
NPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAELIQADLAQVGISVTIVPVEGR
CHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKAL
CHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECEEEECCCCCCCCCEEEEE
SDEGKTP
CCCCCCC
>Mature Secondary Structure
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHH
TLAAQLYDRLLDVDPYTYRLIPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCC
ADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKSVKKLDDYTVEFKLKAPDASF
CHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHH
LWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNVAY
CCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHEEECCCCEEEEECCCCCEEE
LAFNTRKPPLSDQRVRQAIALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEY
EEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEECC
NPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAELIQADLAQVGISVTIVPVEGR
CHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKAL
CHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECEEEECCCCCCCCCEEEEE
SDEGKTP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223423; 11677609 [H]