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The map label for this gene is sapB [H]

Identifier: 170024130

GI number: 170024130

Start: 2097450

End: 2098415

Strand: Reverse

Name: sapB [H]

Synonym: YPK_1891

Alternate gene names: 170024130

Gene position: 2098415-2097450 (Counterclockwise)

Preceding gene: 170024131

Following gene: 170024129

Centisome position: 44.75

GC content: 50.72

Gene sequence:

>966_bases
ATGATTATTTTCACATTACGGCGATTATTACTGCTCGTGATAACCCTGTTTATGTTGTCATTAGTCAGCTTTAGCCTGAG
CTATTTTACCCCCTATGCACCGTTACATGGGGCCGGGTTGCTGGATGCCTACCGCTTCTATTTCAGTAGCTTGTTGCAAT
GGGATTTTGGCATTTCCAGCATTAATGGCCAACCAATCAGCGAGCAACTGCGAGAAGCCTTTCCCGCAACCATGGAATTA
TGTGTACTGGCCTTTGGCCTCGCGCTGTTTATCGGTATTCCGCTGGGCATTATTGCCGGTGTAATGCGGGGTAAATGGGC
GGATATCGCCATCAGTACCGTGGCGTTAATCGGCTTCTCGATCCCCGTATTTTGGCTGGCCCTGTTACTGATGTTGTTCT
TTTCTCTGCATCTGGGGTGGTTACCGGTTTCTGGCCGTTTTGACTTGCTTTATCAAGTAAAACCAGTGACGGGGCTGGCA
TTGGTCGATGCCTGGCTATCGCCCTCACCTTACCGCAACGAAATGATGCTCAGTGCACTTCAACATATGATCCTACCAAT
CACCGCACTGGCCGTGGCACCAACAACCGAGGTCATCCGCTTGATGCGTACCAGCACCGACGACGTTATCGGGCAGAACT
ACATTAAAGCCGCCGCAACCCGTGGGCTATCCCGCTTCACTATTATCCGCCGCCATGTTTTGCATAATGCCTTGCCGCCA
ATTATTCCCAAATTGGGGTTGCAGTTCTCCACCATGCTGACACTGGCCATGATCACCGAGGTGGTCTTTAACTGGCCAGG
GTTAGGACGCTGGCTGATTAATGCGATCCGCCAACAGGACTATGCCGCAATCTCTGCGGGGGTGATGGTCGTGGGTTCGT
TAGTGATCGTTATTAATGTGCTGTCGGATATTCTGGGTGCCATGATGACCCCGTTAAAGCATAAGGAATGGTATGCCCTT
CGATAA

Upstream 100 bases:

>100_bases
TTCAGGCATACCGTTATGACATTAAAGGCTTGGTATTAAGCCCGTTCGGTAACTCTTCTTTCGCCGGTGTATACCGCGAA
AGCGATGAGGGCAAGACGCC

Downstream 100 bases:

>100_bases
TGTCTACCGCGAAAAGAAAATGCCCAGCCCATTGCTGTATACCTGGCGTCTTTTCTCTTCTGATGGCCTGGCGATGGTGG
GTTTCTACGGCGTCTTGGGT

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIIFTLRRLLLLVITLFMLSLVSFSLSYFTPYAPLHGAGLLDAYRFYFSSLLQWDFGISSINGQPISEQLREAFPATMEL
CVLAFGLALFIGIPLGIIAGVMRGKWADIAISTVALIGFSIPVFWLALLLMLFFSLHLGWLPVSGRFDLLYQVKPVTGLA
LVDAWLSPSPYRNEMMLSALQHMILPITALAVAPTTEVIRLMRTSTDDVIGQNYIKAAATRGLSRFTIIRRHVLHNALPP
IIPKLGLQFSTMLTLAMITEVVFNWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIVINVLSDILGAMMTPLKHKEWYAL
R

Sequences:

>Translated_321_residues
MIIFTLRRLLLLVITLFMLSLVSFSLSYFTPYAPLHGAGLLDAYRFYFSSLLQWDFGISSINGQPISEQLREAFPATMEL
CVLAFGLALFIGIPLGIIAGVMRGKWADIAISTVALIGFSIPVFWLALLLMLFFSLHLGWLPVSGRFDLLYQVKPVTGLA
LVDAWLSPSPYRNEMMLSALQHMILPITALAVAPTTEVIRLMRTSTDDVIGQNYIKAAATRGLSRFTIIRRHVLHNALPP
IIPKLGLQFSTMLTLAMITEVVFNWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIVINVLSDILGAMMTPLKHKEWYAL
R
>Mature_321_residues
MIIFTLRRLLLLVITLFMLSLVSFSLSYFTPYAPLHGAGLLDAYRFYFSSLLQWDFGISSINGQPISEQLREAFPATMEL
CVLAFGLALFIGIPLGIIAGVMRGKWADIAISTVALIGFSIPVFWLALLLMLFFSLHLGWLPVSGRFDLLYQVKPVTGLA
LVDAWLSPSPYRNEMMLSALQHMILPITALAVAPTTEVIRLMRTSTDDVIGQNYIKAAATRGLSRFTIIRRHVLHNALPP
IIPKLGLQFSTMLTLAMITEVVFNWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIVINVLSDILGAMMTPLKHKEWYAL
R

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4168

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787550, Length=321, Percent_Identity=76.9470404984424, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1789965, Length=344, Percent_Identity=34.593023255814, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1787053, Length=337, Percent_Identity=30.5637982195846, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787761, Length=249, Percent_Identity=40.9638554216867, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789888, Length=270, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1787497, Length=331, Percent_Identity=28.7009063444109, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788504, Length=269, Percent_Identity=26.7657992565056, Blast_Score=88, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35666; Mature: 35666

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFTLRRLLLLVITLFMLSLVSFSLSYFTPYAPLHGAGLLDAYRFYFSSLLQWDFGISS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
INGQPISEQLREAFPATMELCVLAFGLALFIGIPLGIIAGVMRGKWADIAISTVALIGFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IPVFWLALLLMLFFSLHLGWLPVSGRFDLLYQVKPVTGLALVDAWLSPSPYRNEMMLSAL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHH
QHMILPITALAVAPTTEVIRLMRTSTDDVIGQNYIKAAATRGLSRFTIIRRHVLHNALPP
HHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCH
IIPKLGLQFSTMLTLAMITEVVFNWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIVINV
HHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSDILGAMMTPLKHKEWYALR
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIIFTLRRLLLLVITLFMLSLVSFSLSYFTPYAPLHGAGLLDAYRFYFSSLLQWDFGISS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
INGQPISEQLREAFPATMELCVLAFGLALFIGIPLGIIAGVMRGKWADIAISTVALIGFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IPVFWLALLLMLFFSLHLGWLPVSGRFDLLYQVKPVTGLALVDAWLSPSPYRNEMMLSAL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHH
QHMILPITALAVAPTTEVIRLMRTSTDDVIGQNYIKAAATRGLSRFTIIRRHVLHNALPP
HHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCH
IIPKLGLQFSTMLTLAMITEVVFNWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIVINV
HHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSDILGAMMTPLKHKEWYALR
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]