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The map label for this gene is tppB [H]

Identifier: 170024125

GI number: 170024125

Start: 2090946

End: 2092481

Strand: Reverse

Name: tppB [H]

Synonym: YPK_1886

Alternate gene names: 170024125

Gene position: 2092481-2090946 (Counterclockwise)

Preceding gene: 170024126

Following gene: 170024124

Centisome position: 44.62

GC content: 47.85

Gene sequence:

>1536_bases
ATGACCGGTAGTGAAAAATTAGAGGTCCCAGTGTCAACAGCAAACAACAACCAACCAGAAAGCATCAGTATGAACGCTTT
CAAACAACCAAAAGCGTTTTATCTTATTTTCTCTATAGAACTTTGGGAGCGCTTTGGTTACTACGGCCTGCAAGGGATCA
TGGCTGTCTACCTGGTAAAAATGCTCGGGATGAGCGAAGCCGATTCAATCACCTTGTTCTCCTCATTCAGCGCCTTGGTG
TATGGTTTTGTCGCCATTGGTGGCTGGTTAGGCGATAAAGTCCTTGGGGCGAAGCGGGTTATTGTCCTTGGTGCACTCAC
GCTAGCGGTCGGTTATTCCATGATAGCCTACTCCGGCCACGAGATTTTCTGGGTTTATCTGGGCATGGCAACCATTGCCG
TTGGTAATGGCTTATTTAAAGCCAACCCTTCATCTCTACTTTCAACCTGCTACAGCAAGGACGATCCGCGTTTGGACGGT
GCATTTACCATGTACTATATGTCCATCAATATCGGTTCGTTCTTCTCTATGTTGGCAACCCCATGGCTGGCGGCTAAATA
TGGCTGGAGCGTTGCGTTTTCTCTGAGCGTTGTGGGGATGTTGATTACACTGGTCAATTTCTGGTTCTGCCGTAAATGGG
TAAAAAACCAAGGCTCCAAACCAGACTTTCTCCCTCTGCAATTTAAAAAATTACTGATGGTCTTAGTGGGTATTATCGCG
TTGATAACCCTTTCCAACTGGTTACTCCACAACCAGATTATTGCACGCTGGGCGCTGGCACTGGTCTCCCTAGGGATTAT
CTTCATCTTTACCAAAGAAACGCTCTTCTTGCAGGGCATTGCGCGCCGCAGAATGATTGTCGCCTTCTTGTTGATGCTGG
AAGCGGTCATTTTCTTTGTGCTATACAGCCAAATGCCAACCTCACTGAACTTCTTCGCTATCCACAATGTGGAGCACTCA
ATCTTTGGCATTGGTTTTGAACCAGAACAATTTCAGGCACTGAATCCCTTCTGGATCATGCTTGCCAGCCCTATTTTGGC
GGCTATCTATAATAAGATGGGCGACCGTCTACCAATGCCGCATAAGTTTGCCTTTGGTATGATGCTCTGCTCCGCTGCCT
TCTTGGTGCTGCCATGGGGAGCAAGCTTTGCTAATGAACACGGTATTGTGTCTGTTAACTGGCTTATCTTAAGTTATGCA
CTGCAAAGTATCGGTGAGTTGATGATCTCCGGCTTAGGTCTGGCCATGGTTGCTCAATTAGTACCTCAGCGTTTAATGGG
CTTCATCATGGGGTCATGGTTCCTGACTACCGCGGCCGCGGCTCTGATCGCGGGTAAAGTGGCCGCATTGACTGCGGTCC
CAAGTGATGCCATCACTGACGCACATGCATCCCTGGCGATTTATAGCCACGTATTTATGCAAATTGGTATTGTGACCGCC
ATTATCGCCGTACTGATGATGCTGACTGCACCGAAACTGTATCGTATGACGCTGGCCCCTAGCGATCACAACGATGTCAA
AATCATGACCCAATAA

Upstream 100 bases:

>100_bases
TCTCACTGACAAAGATAGTGAACATTAACCGCCGCTAATCATCTTATAACAACACAAAAGGGTGTGATTTTCACATTCAC
TTTTGTCTTTCCTGTCAGTT

Downstream 100 bases:

>100_bases
GCTGACTAAACGCGCTCCTGCGGGAGCGCTTTTAGTGCTAGTTAGGTGCCCCCGACCTGCACACCTGCCCCCCTACACAA
CAACAGATTGCTCAAAAAAA

Product: putative tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTGSEKLEVPVSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALV
YGFVAIGGWLGDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDG
AFTMYYMSINIGSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIA
LITLSNWLLHNQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHS
IFGIGFEPEQFQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYA
LQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTA
IIAVLMMLTAPKLYRMTLAPSDHNDVKIMTQ

Sequences:

>Translated_511_residues
MTGSEKLEVPVSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALV
YGFVAIGGWLGDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDG
AFTMYYMSINIGSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIA
LITLSNWLLHNQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHS
IFGIGFEPEQFQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYA
LQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTA
IIAVLMMLTAPKLYRMTLAPSDHNDVKIMTQ
>Mature_510_residues
TGSEKLEVPVSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALVY
GFVAIGGWLGDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDGA
FTMYYMSINIGSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIAL
ITLSNWLLHNQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHSI
FGIGFEPEQFQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYAL
QSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTAI
IAVLMMLTAPKLYRMTLAPSDHNDVKIMTQ

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=22.9974160206718, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787922, Length=486, Percent_Identity=75.7201646090535, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=493, Percent_Identity=51.7241379310345, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1786927, Length=479, Percent_Identity=30.4801670146138, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1790572, Length=473, Percent_Identity=30.4439746300211, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17541704, Length=397, Percent_Identity=23.4256926952141, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569141, Length=372, Percent_Identity=25.2688172043011, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71987453, Length=379, Percent_Identity=22.9551451187335, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639585, Length=346, Percent_Identity=25.4335260115607, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639581, Length=344, Percent_Identity=26.453488372093, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24639583, Length=331, Percent_Identity=25.9818731117825, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571098, Length=391, Percent_Identity=24.2966751918159, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571102, Length=391, Percent_Identity=24.2966751918159, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571100, Length=391, Percent_Identity=24.2966751918159, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 56354; Mature: 56223

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSEKLEVPVSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVK
CCCCCCEEEEEECCCCCCCCCEECCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHH
MLGMSEADSITLFSSFSALVYGFVAIGGWLGDKVLGAKRVIVLGALTLAVGYSMIAYSGH
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
EIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDGAFTMYYMSINIGSFFSMLAT
EEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHC
PWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LITLSNWLLHNQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYSQMPTSLNFFAIHNVEHSIFGIGFEPEQFQALNPFWIMLASPILAAIYNKMGDRLPMP
HHHCCCCCCEEEEEECCCHHEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
HKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYALQSIGELMISGLGLAMVAQL
HHHHHHHHHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
IIAVLMMLTAPKLYRMTLAPSDHNDVKIMTQ
HHHHHHHHCCCHHEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
TGSEKLEVPVSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVK
CCCCCEEEEEECCCCCCCCCEECCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHH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HHHHHHHHCCCHHEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]