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The map label for this gene is alr2 [H]

Identifier: 170024003

GI number: 170024003

Start: 1960360

End: 1961589

Strand: Reverse

Name: alr2 [H]

Synonym: YPK_1764

Alternate gene names: 170024003

Gene position: 1961589-1960360 (Counterclockwise)

Preceding gene: 170024004

Following gene: 170023983

Centisome position: 41.83

GC content: 45.04

Gene sequence:

>1230_bases
ATGCACGTTCGTTTTCATCATTTATTCTTATTACCATTAATAACTTTGGTCGCTTGTAGCCAACCCGTATCAAAAAACCA
TCTTAGCCTGACCTCACTATCTGCCAACGCCCAGCAACCTGTAGTAAATAATGCGTGGCTTGAAATCTCTCAAGGTGCGC
TGGATTTCAATACTAAAAAGATGCTTACACTGCTGGATAATAAATCCACACTTTGTGCAATATTAAAAGGTGATGCCTAT
GGACATGACCTGACCTTAGTCACACCGGTGATGCTAAAAAACAATGTGCAATGTATTGGGGTTGCCAGCAATCAGGAACT
AAAAACGGTACGTGATCTAGGATTTACGGGGCAGTTGATACGGGTCAGAAGTGCAACATTAAAAGAAATGCAACAAGCTA
TGGCTTACGATGTTGAAGAACTTATTGGCGATAAAACCGTCGCTGAGCAGTTAAATAATATTGCAAAACTGAATGGAAAA
GTTCTGCGTATCCATCTGGCACTGAACTCCGCAGGGATGTCTCGTAATGGGCTGGAGGTCAGTAAGGCCCGCGGTTTAAA
TGACGCAAAGACAATTGTAGGTTTAAAAAATCTGACAATCGTTGGCATCATGTCGCACTACCCGGTGGAAGATGCTAGCG
AAATCAAAGCAGACTTGGCTCGATTCCAGCAACAAGCCAAAGATGTTATCGCGGTCACGGGGCTAAAACGTGAAAAGATT
AAGCTCCACGTCGCCAATACATTCGCGACCTTAGCGGTGCCTGATTCATGGTTGGATATGGTCCGTGTGGGAGGGGTGTT
TTATGGTGACACCATCGCCAGCACAGAGTATAAGCGGGTCATGACCTTCAAATCTAACATCGCATCGCTGAACAACTACC
CTAAGGGCGGTACTGTTGGCTATGACCGGACCTATACATTGAAACGTGATTCCCTGCTGGCGAATATCCCCGTGGGTTAT
GCCGATGGGTATCGCCGAGTATTTAGTAATGCGGGGCATGTGATTATTCAAGGTCAGCGCCTGCCCGTATTAGGCAAAAC
ATCAATGAATACGGTCATGGTAGACGTCACCGATCTGAAAAAAGTGAGTTTAGGTGATGAAGTTGTCTTGTTCGGTAAGC
AAGGCAATGCGGAAATTCAGGCAGAAGAAATTGAAGATCTCAGTGGCGCACTCTTTACCGAAATGTCAATTCTGTGGGGC
GCAACCAATAAGCGTATTCTGGTAGATTAA

Upstream 100 bases:

>100_bases
ACAAACCTCGTCACAAAAATATATTTTTAATAAAAATCCTATACCAGTTACTTCATTGTTTTAGTTAAAAAACTAATAGG
AAATTTATTCAGGAGATTTC

Downstream 100 bases:

>100_bases
GTTATTTCACCGTCTGTTTTCATTAACACTGTCGTGAAAACAGACGGCCAGTATTGCGTATAACCCCCTTTATCCCGATA
ACTTGTTTTCAACGAGTGAC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHVRFHHLFLLPLITLVACSQPVSKNHLSLTSLSANAQQPVVNNAWLEISQGALDFNTKKMLTLLDNKSTLCAILKGDAY
GHDLTLVTPVMLKNNVQCIGVASNQELKTVRDLGFTGQLIRVRSATLKEMQQAMAYDVEELIGDKTVAEQLNNIAKLNGK
VLRIHLALNSAGMSRNGLEVSKARGLNDAKTIVGLKNLTIVGIMSHYPVEDASEIKADLARFQQQAKDVIAVTGLKREKI
KLHVANTFATLAVPDSWLDMVRVGGVFYGDTIASTEYKRVMTFKSNIASLNNYPKGGTVGYDRTYTLKRDSLLANIPVGY
ADGYRRVFSNAGHVIIQGQRLPVLGKTSMNTVMVDVTDLKKVSLGDEVVLFGKQGNAEIQAEEIEDLSGALFTEMSILWG
ATNKRILVD

Sequences:

>Translated_409_residues
MHVRFHHLFLLPLITLVACSQPVSKNHLSLTSLSANAQQPVVNNAWLEISQGALDFNTKKMLTLLDNKSTLCAILKGDAY
GHDLTLVTPVMLKNNVQCIGVASNQELKTVRDLGFTGQLIRVRSATLKEMQQAMAYDVEELIGDKTVAEQLNNIAKLNGK
VLRIHLALNSAGMSRNGLEVSKARGLNDAKTIVGLKNLTIVGIMSHYPVEDASEIKADLARFQQQAKDVIAVTGLKREKI
KLHVANTFATLAVPDSWLDMVRVGGVFYGDTIASTEYKRVMTFKSNIASLNNYPKGGTVGYDRTYTLKRDSLLANIPVGY
ADGYRRVFSNAGHVIIQGQRLPVLGKTSMNTVMVDVTDLKKVSLGDEVVLFGKQGNAEIQAEEIEDLSGALFTEMSILWG
ATNKRILVD
>Mature_409_residues
MHVRFHHLFLLPLITLVACSQPVSKNHLSLTSLSANAQQPVVNNAWLEISQGALDFNTKKMLTLLDNKSTLCAILKGDAY
GHDLTLVTPVMLKNNVQCIGVASNQELKTVRDLGFTGQLIRVRSATLKEMQQAMAYDVEELIGDKTVAEQLNNIAKLNGK
VLRIHLALNSAGMSRNGLEVSKARGLNDAKTIVGLKNLTIVGIMSHYPVEDASEIKADLARFQQQAKDVIAVTGLKREKI
KLHVANTFATLAVPDSWLDMVRVGGVFYGDTIASTEYKRVMTFKSNIASLNNYPKGGTVGYDRTYTLKRDSLLANIPVGY
ADGYRRVFSNAGHVIIQGQRLPVLGKTSMNTVMVDVTDLKKVSLGDEVVLFGKQGNAEIQAEEIEDLSGALFTEMSILWG
ATNKRILVD

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1787439, Length=359, Percent_Identity=26.1838440111421, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1790487, Length=345, Percent_Identity=26.3768115942029, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 44797; Mature: 44797

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVRFHHLFLLPLITLVACSQPVSKNHLSLTSLSANAQQPVVNNAWLEISQGALDFNTKK
CCEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCE
MLTLLDNKSTLCAILKGDAYGHDLTLVTPVMLKNNVQCIGVASNQELKTVRDLGFTGQLI
EEEEECCCCEEEEEEECCCCCCCEEEEEHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEE
RVRSATLKEMQQAMAYDVEELIGDKTVAEQLNNIAKLNGKVLRIHLALNSAGMSRNGLEV
EHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCH
SKARGLNDAKTIVGLKNLTIVGIMSHYPVEDASEIKADLARFQQQAKDVIAVTGLKREKI
HHHCCCCCHHHHEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCEEE
KLHVANTFATLAVPDSWLDMVRVGGVFYGDTIASTEYKRVMTFKSNIASLNNYPKGGTVG
EEEEECEEEEEECCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YDRTYTLKRDSLLANIPVGYADGYRRVFSNAGHVIIQGQRLPVLGKTSMNTVMVDVTDLK
CCEEEEEECCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCEECCCCCCEEEEEEECCE
KVSLGDEVVLFGKQGNAEIQAEEIEDLSGALFTEMSILWGATNKRILVD
EECCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHEECCCCCEEEEC
>Mature Secondary Structure
MHVRFHHLFLLPLITLVACSQPVSKNHLSLTSLSANAQQPVVNNAWLEISQGALDFNTKK
CCEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCE
MLTLLDNKSTLCAILKGDAYGHDLTLVTPVMLKNNVQCIGVASNQELKTVRDLGFTGQLI
EEEEECCCCEEEEEEECCCCCCCEEEEEHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEE
RVRSATLKEMQQAMAYDVEELIGDKTVAEQLNNIAKLNGKVLRIHLALNSAGMSRNGLEV
EHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCH
SKARGLNDAKTIVGLKNLTIVGIMSHYPVEDASEIKADLARFQQQAKDVIAVTGLKREKI
HHHCCCCCHHHHEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCEEE
KLHVANTFATLAVPDSWLDMVRVGGVFYGDTIASTEYKRVMTFKSNIASLNNYPKGGTVG
EEEEECEEEEEECCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YDRTYTLKRDSLLANIPVGYADGYRRVFSNAGHVIIQGQRLPVLGKTSMNTVMVDVTDLK
CCEEEEEECCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCEECCCCCCEEEEEEECCE
KVSLGDEVVLFGKQGNAEIQAEEIEDLSGALFTEMSILWGATNKRILVD
EECCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]