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The map label for this gene is nanT [H]

Identifier: 170023649

GI number: 170023649

Start: 1550617

End: 1552149

Strand: Direct

Name: nanT [H]

Synonym: YPK_1407

Alternate gene names: 170023649

Gene position: 1550617-1552149 (Clockwise)

Preceding gene: 170023648

Following gene: 170023650

Centisome position: 33.07

GC content: 50.55

Gene sequence:

>1533_bases
ATGAGTATTTCAGTAGGTCCATCTCGTGAAGATAAACCATTATCGGGTGGCGCTAAACCACCCCGTTGGTACAAACAACT
TACCCCGGCGCAATGGAAGGCCTTTGTTGCCGCTTGGATCGGTTATGCCCTGGATGGCTTTGACTTTGTTCTGATTACTC
TGGTTCTGACCGATATTAAACAAGAATTTGGCCTGACACTGATTCAGGCGACCAGCCTGATTTCTGCTGCCTTCATCTCA
CGCTGGTTTGGTGGGTTGGTACTGGGTGCGATGGGGGATCGCTATGGCCGTAAACTGGCCATGATCATCAGTATTGTGTT
GTTCTCCTTCGGTACGTTGGCCTGTGGCTTAGCACCTGGCTACACCACGCTGTTTATTGCTCGCTTGATTATCGGTATTG
GCATGGCGGGTGAGTATGGTTCCAGCTCGACCTATGTGATGGAAAGCTGGCCTAAAAACATGCGTAATAAAGCCAGTGGC
TTCCTGATTTCTGGCTTCTCTATCGGTGCGGTACTCGCGGCGCAAGCCTACAGCTACGTGGTGCCCGCATTTGGTTGGCG
TATGTTGTTCTACATTGGATTATTGCCAATTATCTTTGCACTGTGGTTGCGTAAAAACCTACCGGAAGCAGAGGACTGGG
AAAAGGCACAAAGTAAGCAGAAAAAAGGTAAACAGGTCACTGACCGGAATATGGTGGATATTCTGTATCGCAGTCACCTC
AGTTATCTGAATATTGGCCTGACGATATTTGCCGCTGTCTCACTTTACCTCTGTTTTACTGGCATGGTCTCGACGTTGCT
GGTAGTGGTTCTCGGTATTCTTTGCGCTGCAATATTTATCTATTTTATGGTTCAAACCAGTGGCGATCGCTGGCCTACGG
GCGTCATGCTGATGGTCGTGGTGTTCTGTGCGTTCCTCTACTCTTGGCCGATCCAGGCGTTGTTACCGACCTACCTGAAA
ATGGATCTCGGCTATGACCCACACACCGTAGGCAATATATTGTTCTTCAGTGGTTTTGGTGCGGCCGTGGGTTGTTGTGT
TGGCGGTTTCCTTGGCGATTGGTTGGGTACCCGCAAAGCCTATGTGACCAGTTTGCTGATATCACAGCTCTTGATCATCC
CGCTGTTTGCCATCCAAGGCAGCAGTATTTTGTTCTTAGGGGGATTACTGTTCTTACAACAGATGCTGGGGCAGGGGATT
GCGGGCCTGTTGCCGAAACTGCTGGGCGGTTATTTTGATACCGAACAGCGAGCCGCAGGACTGGGCTTTACCTACAACGT
CGGCGCATTGGGAGGGGCATTGGCCCCCATACTGGGGGCATCGATTGCTCAACATCTCAGTTTAGGCACCGCGTTGGGAT
CGCTCTCTTTCAGTCTGACATTCGTGGTGATCCTACTGATTGGTTTTGATATGCCATCCCGTGTACAGCGTTGGGTCCGC
CCATCAGGTTTACGGATGGTGGATGCCATCGATGGCAAACCATTCAGTGGTGCCATTACGGCCCAGCATGCGCGAGTAGT
GACACAGAAATAA

Upstream 100 bases:

>100_bases
AAAGTGATTATAAACAATCACATGCTATGGTTGTACATGCCTCGGGGAAAACCGTTACTGCTGGTGCCATCATTGCCAGT
GGGGAAGAGAGAGCGATGAT

Downstream 100 bases:

>100_bases
CGTTTTTTCAGCCAGAATTTACTTTTCATCCATCATTTATTTTTCATCCATAAACTGTTTTTCTTGCCCGGTGCGCGACG
ACCGGGCTTTTTTTAATTTG

Product: putative sialic acid transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: Sialic acid permease [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFIS
RWFGGLVLGAMGDRYGRKLAMIISIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASG
FLISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHL
SYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLK
MDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGI
AGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVR
PSGLRMVDAIDGKPFSGAITAQHARVVTQK

Sequences:

>Translated_510_residues
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFIS
RWFGGLVLGAMGDRYGRKLAMIISIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASG
FLISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHL
SYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLK
MDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGI
AGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVR
PSGLRMVDAIDGKPFSGAITAQHARVVTQK
>Mature_509_residues
SISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFISR
WFGGLVLGAMGDRYGRKLAMIISIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASGF
LISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHLS
YLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLKM
DLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGIA
GLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVRP
SGLRMVDAIDGKPFSGAITAQHARVVTQK

Specific function: May be a sugar-cation symporter involved in sialic acid uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter family. Sialic acid transporter (TC 2.A.1.12.1) subfamily [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=204, Percent_Identity=24.5098039215686, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87082231, Length=484, Percent_Identity=75.2066115702479, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=455, Percent_Identity=37.1428571428571, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI1790550, Length=510, Percent_Identity=24.9019607843137, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788292, Length=459, Percent_Identity=22.6579520697168, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788942, Length=283, Percent_Identity=27.5618374558304, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081723, Length=410, Percent_Identity=27.0731707317073, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32564663, Length=193, Percent_Identity=25.9067357512953, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=218, Percent_Identity=27.5229357798165, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322632, Length=428, Percent_Identity=22.196261682243, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55275; Mature: 55144

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIK
CCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
QEFGLTLIQATSLISAAFISRWFGGLVLGAMGDRYGRKLAMIISIVLFSFGTLACGLAPG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASGFLISGFSIGAVLAAQAYSYV
HHHHHHHHHHHHCCCCCCCCCCCCEEHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHH
VPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
SYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VFCAFLYSWPIQALLPTYLKMDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKA
HHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
YVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGIAGLLPKLLGGYFDTEQRAAG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHCC
LGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
PSGLRMVDAIDGKPFSGAITAQHARVVTQK
CCCCEEEECCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIK
CCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH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CCCCEEEECCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA