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The map label for this gene is tetR [H]

Identifier: 169629466

GI number: 169629466

Start: 2438263

End: 2438922

Strand: Reverse

Name: tetR [H]

Synonym: MAB_2380c

Alternate gene names: 169629466

Gene position: 2438922-2438263 (Counterclockwise)

Preceding gene: 169629479

Following gene: 169629464

Centisome position: 48.13

GC content: 63.64

Gene sequence:

>660_bases
ATGTCAATGCGCGCAGACGAAACAACCAGGCGTGGCGCCACCCTGCAATTGGAAGCAGTCGTGACCCAGGCGCTCGCGCT
GGTCAACGAGGGCGGGCTGGAGGCCCTGACGATGAGGCGGCTCGCTACCGACCTCGACGCGCATCTCCCGACGCTCTATC
GACTGTTCGGCAATAAGGACGCGCTCATCGATGAGATGGCCGAGTCGATCCTGGCCCAGGCGTCAGCCAATGCCCAAGCC
GGGCGGGGCAATTGGGATGACAAGCTGGTAGATCTCGCCCGGTCCTTGCGGTCCGCCCTGCTCGGCCAGCGCGACGGAGC
GCGAATCGTCGGCGGAAACTATGCCGCCAAACGGCACAATTTGACCTTTGTCGACCTGCTGGTGGCGCATGCGTCCAAAT
CCGGGCTAGCGCCAGAATCTGCGCTGTGGGCCGCCAGTTCGGTCTTCTGCTTTGTGTTGGGCGAGGCACTCGAACAGCAG
GGCGCTACTGGGGAGGAGCTCGACGCCGTCAGGGGCATCGCGCATCCTGAGCTGTATCCGCATCTTGCCGCCAGTCCGGT
GGAGCGGCTCTTCGAATTCGAGGAAAGATTCGATTTCGGTCTTGGCCTGCTCGTCGGCGGGATGCGTCGACTTCTGGAGG
CAGTGCCGTCGCCTGGATAG

Upstream 100 bases:

>100_bases
GAACGGCGACCTTCAGTGTGGCACCGGTATCATTCATGCTTGTCAGCCCATCTGTTAACAACGTTAATTCTCCTTCAAAC
ATACTGATAACATCGATAAC

Downstream 100 bases:

>100_bases
ACCACATTGTCACATTGGTCGGACCGACAGGATTTGAACCTGCGACCACTTGACCCCCAGTACAGATACGAAGGCGCTAT
CACTGGTCAGGGAGGTTTTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSMRADETTRRGATLQLEAVVTQALALVNEGGLEALTMRRLATDLDAHLPTLYRLFGNKDALIDEMAESILAQASANAQA
GRGNWDDKLVDLARSLRSALLGQRDGARIVGGNYAAKRHNLTFVDLLVAHASKSGLAPESALWAASSVFCFVLGEALEQQ
GATGEELDAVRGIAHPELYPHLAASPVERLFEFEERFDFGLGLLVGGMRRLLEAVPSPG

Sequences:

>Translated_219_residues
MSMRADETTRRGATLQLEAVVTQALALVNEGGLEALTMRRLATDLDAHLPTLYRLFGNKDALIDEMAESILAQASANAQA
GRGNWDDKLVDLARSLRSALLGQRDGARIVGGNYAAKRHNLTFVDLLVAHASKSGLAPESALWAASSVFCFVLGEALEQQ
GATGEELDAVRGIAHPELYPHLAASPVERLFEFEERFDFGLGLLVGGMRRLLEAVPSPG
>Mature_218_residues
SMRADETTRRGATLQLEAVVTQALALVNEGGLEALTMRRLATDLDAHLPTLYRLFGNKDALIDEMAESILAQASANAQAG
RGNWDDKLVDLARSLRSALLGQRDGARIVGGNYAAKRHNLTFVDLLVAHASKSGLAPESALWAASSVFCFVLGEALEQQG
ATGEELDAVRGIAHPELYPHLAASPVERLFEFEERFDFGLGLLVGGMRRLLEAVPSPG

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23538; Mature: 23407

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMRADETTRRGATLQLEAVVTQALALVNEGGLEALTMRRLATDLDAHLPTLYRLFGNKD
CCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALIDEMAESILAQASANAQAGRGNWDDKLVDLARSLRSALLGQRDGARIVGGNYAAKRHN
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHCC
LTFVDLLVAHASKSGLAPESALWAASSVFCFVLGEALEQQGATGEELDAVRGIAHPELYP
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
HLAASPVERLFEFEERFDFGLGLLVGGMRRLLEAVPSPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SMRADETTRRGATLQLEAVVTQALALVNEGGLEALTMRRLATDLDAHLPTLYRLFGNKD
CCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALIDEMAESILAQASANAQAGRGNWDDKLVDLARSLRSALLGQRDGARIVGGNYAAKRHN
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHCC
LTFVDLLVAHASKSGLAPESALWAASSVFCFVLGEALEQQGATGEELDAVRGIAHPELYP
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
HLAASPVERLFEFEERFDFGLGLLVGGMRRLLEAVPSPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1479961 [H]