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The map label for this gene is ubiB [C]

Identifier: 169629479

GI number: 169629479

Start: 2448569

End: 2450089

Strand: Reverse

Name: ubiB [C]

Synonym: MAB_2393c

Alternate gene names: 169629479

Gene position: 2450089-2448569 (Counterclockwise)

Preceding gene: 169629494

Following gene: 169629466

Centisome position: 48.35

GC content: 63.71

Gene sequence:

>1521_bases
ATGAGCACCCCCGAGGGCGCGGGCAACGACGCGGCGCCCCTCGCTGCCGAACTGTCCGAGAACGGGAAACAACAGCCCGT
CATCCCGGAATCTACCTCGGAGCCACCGTCGGCGGGGGCAGATTCGCGTCCTGCCGGCGCAACGATAGATCTCGAGATCA
CCCGTCCGCGAGTCAGACTGCGTCAGCCGCCACTGCGCGTGGAGGCCGGGCGTTTTGGCCTGACAGTCTCCCGGCTGGCC
GGATCGGGCGCGCGATTGCTGGTCAAACCGCGGCGTGGAAGATCCCTGGAGGTGCGCGCCGCGCATGAGCTGCGGCGCAC
CTTCGCCCTCATGGGCCCCACCTACGTCAAACTCGGCCAGCTCATCGCCTCCTCCCCCGGAGTCTTCCCCGAAACACTCT
CCAACGAGTTCCGGACACTGCTCGACAGGGTGCCACCGGCCTCCTCGCAGTTGATTCGCCAGACCGTGCGAGAACAGTTG
GGTGCCGATCCGGCAACGATATTCGCCACTTTCGACGAGCATCCGTTCGCCTCGGCATCCATTGCCCAGGTTCACCACGC
CACCCTCAAATCCGGTGAACGGGTGGTGGTCAAGATTCAGCGCCCGAAGATCCGTACCCGGCTTGCCGCCGACGTGCGCA
TCATCGGGCGACTCGCGCGCTTGATCGTCAAAACCGATCTGGGCCGGGCCACCAACGCCATAGAGGTGGTCGAGGACTTT
GAGCAGAACCTCAACGAAGAGCTGGATTTCGCGGCCGAGGGGCACGCGATGGAACAGTGGATCGCCAGTCTTGCCGATAC
CGAATACGGCGACAAGGTGCGCGTCCCCAAGGTGTTTTGGGAGTACACCACCGAGCGGGTGCTCACGATGGAGTATGTCC
AAGGCATCCGCATCGACAACATCACCGAGCTGGCCGCGGCAGGCTTCGACGGCGTCGCGTTGGTCAAGGCGATCGTCTAT
TCACTGTTCGAAACGGGCTTTCACAAGGGCCTCTTCCACGGAGATCTGCATGCCGGCAATTTGTTGGTGGACTCCGACGG
CCGGATCGTGTTTCTCGACTTCGGCATCGTCGGGCGCATCGACGACCGCAGCCGCAAGATCTTCACCGAGATCATGGTCG
ATCTGTTCGTGAAGAACGACCACGCGGCCGTGGCCAGGGGCATCTACAAGCTGGGCGCGATCGGCGACCGGGGCAAGGTA
GCCGATTCGACGACTGCCGCCAAGACGATTTCCAACTTCACGAGCCCGCTGCAGCAGTCCAAACTCTCGGCCATTGAGTA
CGGCCAGTTGGGCAAGCAGTTGGCCGTGCTGGCCAAGGAATACGACGTGCGGCTGCCCCGCGAGCTGGTGCTGATCTCCA
AACAGCTGCTCTATGTCGAGCGCTACATGAAGCTACTGGCCCCCGACTGGGCACTGCTCGCCGATCCGTCGTTCATCGGG
TACTTCGGCAACATGGTCATTGCGGCCGAGCAGTCGCGCCTGGAGGACGCGGCGGCACGGCAGCCGGTGCGCGGCAGCTG
A

Upstream 100 bases:

>100_bases
CGACAGGCCTGTGGGTGTTGGCGCGGGATTCGACAGCTACTCAGCGGTAGCCCGGCGCACGTTACATACAACTGTGCTCG
TATGTATTACAGTGGCGCTC

Downstream 100 bases:

>100_bases
ACTCTAGTCGGAAAGGCTCAGCTTTCCGGGGTCGATTGTGCGCAGAGCCGAGTCGAGCGGTGCACCTACCGCGGGCGACT
CGACGATGTTCAACAACATC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSTPEGAGNDAAPLAAELSENGKQQPVIPESTSEPPSAGADSRPAGATIDLEITRPRVRLRQPPLRVEAGRFGLTVSRLA
GSGARLLVKPRRGRSLEVRAAHELRRTFALMGPTYVKLGQLIASSPGVFPETLSNEFRTLLDRVPPASSQLIRQTVREQL
GADPATIFATFDEHPFASASIAQVHHATLKSGERVVVKIQRPKIRTRLAADVRIIGRLARLIVKTDLGRATNAIEVVEDF
EQNLNEELDFAAEGHAMEQWIASLADTEYGDKVRVPKVFWEYTTERVLTMEYVQGIRIDNITELAAAGFDGVALVKAIVY
SLFETGFHKGLFHGDLHAGNLLVDSDGRIVFLDFGIVGRIDDRSRKIFTEIMVDLFVKNDHAAVARGIYKLGAIGDRGKV
ADSTTAAKTISNFTSPLQQSKLSAIEYGQLGKQLAVLAKEYDVRLPRELVLISKQLLYVERYMKLLAPDWALLADPSFIG
YFGNMVIAAEQSRLEDAAARQPVRGS

Sequences:

>Translated_506_residues
MSTPEGAGNDAAPLAAELSENGKQQPVIPESTSEPPSAGADSRPAGATIDLEITRPRVRLRQPPLRVEAGRFGLTVSRLA
GSGARLLVKPRRGRSLEVRAAHELRRTFALMGPTYVKLGQLIASSPGVFPETLSNEFRTLLDRVPPASSQLIRQTVREQL
GADPATIFATFDEHPFASASIAQVHHATLKSGERVVVKIQRPKIRTRLAADVRIIGRLARLIVKTDLGRATNAIEVVEDF
EQNLNEELDFAAEGHAMEQWIASLADTEYGDKVRVPKVFWEYTTERVLTMEYVQGIRIDNITELAAAGFDGVALVKAIVY
SLFETGFHKGLFHGDLHAGNLLVDSDGRIVFLDFGIVGRIDDRSRKIFTEIMVDLFVKNDHAAVARGIYKLGAIGDRGKV
ADSTTAAKTISNFTSPLQQSKLSAIEYGQLGKQLAVLAKEYDVRLPRELVLISKQLLYVERYMKLLAPDWALLADPSFIG
YFGNMVIAAEQSRLEDAAARQPVRGS
>Mature_505_residues
STPEGAGNDAAPLAAELSENGKQQPVIPESTSEPPSAGADSRPAGATIDLEITRPRVRLRQPPLRVEAGRFGLTVSRLAG
SGARLLVKPRRGRSLEVRAAHELRRTFALMGPTYVKLGQLIASSPGVFPETLSNEFRTLLDRVPPASSQLIRQTVREQLG
ADPATIFATFDEHPFASASIAQVHHATLKSGERVVVKIQRPKIRTRLAADVRIIGRLARLIVKTDLGRATNAIEVVEDFE
QNLNEELDFAAEGHAMEQWIASLADTEYGDKVRVPKVFWEYTTERVLTMEYVQGIRIDNITELAAAGFDGVALVKAIVYS
LFETGFHKGLFHGDLHAGNLLVDSDGRIVFLDFGIVGRIDDRSRKIFTEIMVDLFVKNDHAAVARGIYKLGAIGDRGKVA
DSTTAAKTISNFTSPLQQSKLSAIEYGQLGKQLAVLAKEYDVRLPRELVLISKQLLYVERYMKLLAPDWALLADPSFIGY
FGNMVIAAEQSRLEDAAARQPVRGS

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=367, Percent_Identity=28.8828337874659, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI41393593, Length=295, Percent_Identity=29.4915254237288, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI217035081, Length=347, Percent_Identity=27.9538904899135, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI27363457, Length=323, Percent_Identity=27.8637770897833, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI217416386, Length=269, Percent_Identity=30.1115241635688, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI34147522, Length=282, Percent_Identity=25.177304964539, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI2367309, Length=372, Percent_Identity=29.8387096774194, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17559152, Length=364, Percent_Identity=28.021978021978, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565180, Length=251, Percent_Identity=30.2788844621514, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=332, Percent_Identity=24.0963855421687, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=195, Percent_Identity=31.7948717948718, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=260, Percent_Identity=24.2307692307692, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI22024280, Length=366, Percent_Identity=27.8688524590164, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24662575, Length=334, Percent_Identity=29.940119760479, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18859849, Length=250, Percent_Identity=30.8, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 55488; Mature: 55357

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPEGAGNDAAPLAAELSENGKQQPVIPESTSEPPSAGADSRPAGATIDLEITRPRVRL
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHC
RQPPLRVEAGRFGLTVSRLAGSGARLLVKPRRGRSLEVRAAHELRRTFALMGPTYVKLGQ
CCCCCEEECCCCCCCHHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCHHHHHHH
LIASSPGVFPETLSNEFRTLLDRVPPASSQLIRQTVREQLGADPATIFATFDEHPFASAS
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
IAQVHHATLKSGERVVVKIQRPKIRTRLAADVRIIGRLARLIVKTDLGRATNAIEVVEDF
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EQNLNEELDFAAEGHAMEQWIASLADTEYGDKVRVPKVFWEYTTERVLTMEYVQGIRIDN
HHHHHHHHCHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ITELAAAGFDGVALVKAIVYSLFETGFHKGLFHGDLHAGNLLVDSDGRIVFLDFGIVGRI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCEEECC
DDRSRKIFTEIMVDLFVKNDHAAVARGIYKLGAIGDRGKVADSTTAAKTISNFTSPLQQS
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLSAIEYGQLGKQLAVLAKEYDVRLPRELVLISKQLLYVERYMKLLAPDWALLADPSFIG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHH
YFGNMVIAAEQSRLEDAAARQPVRGS
HHCCEEEEECHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STPEGAGNDAAPLAAELSENGKQQPVIPESTSEPPSAGADSRPAGATIDLEITRPRVRL
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHC
RQPPLRVEAGRFGLTVSRLAGSGARLLVKPRRGRSLEVRAAHELRRTFALMGPTYVKLGQ
CCCCCEEECCCCCCCHHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCHHHHHHH
LIASSPGVFPETLSNEFRTLLDRVPPASSQLIRQTVREQLGADPATIFATFDEHPFASAS
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
IAQVHHATLKSGERVVVKIQRPKIRTRLAADVRIIGRLARLIVKTDLGRATNAIEVVEDF
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EQNLNEELDFAAEGHAMEQWIASLADTEYGDKVRVPKVFWEYTTERVLTMEYVQGIRIDN
HHHHHHHHCHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ITELAAAGFDGVALVKAIVYSLFETGFHKGLFHGDLHAGNLLVDSDGRIVFLDFGIVGRI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCEEECC
DDRSRKIFTEIMVDLFVKNDHAAVARGIYKLGAIGDRGKVADSTTAAKTISNFTSPLQQS
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLSAIEYGQLGKQLAVLAKEYDVRLPRELVLISKQLLYVERYMKLLAPDWALLADPSFIG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHH
YFGNMVIAAEQSRLEDAAARQPVRGS
HHCCEEEEECHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]