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The map label for this gene is tcmP [H]

Identifier: 169629345

GI number: 169629345

Start: 2303551

End: 2304351

Strand: Direct

Name: tcmP [H]

Synonym: MAB_2259

Alternate gene names: 169629345

Gene position: 2303551-2304351 (Clockwise)

Preceding gene: 169629344

Following gene: 169629346

Centisome position: 45.46

GC content: 57.18

Gene sequence:

>801_bases
ATGGCACAGATCGACCTGAGCGGTGTAGCGGAGACAGCAATGTGGACGCTGTACACCCGTGCGAACGAAGCGCAACGGTC
TGATGGCGTCCTGAAGGACCCGCGGTGTATCGAGTTGTTCGAATCCATCGACTACCCCTATGAAAGCAAGTTTGGAAAAG
ACCAGACCGGCTTGCATGGTGAGAAATCTCGAATCTTCGACGTCGTGGTTCGTCAGTGGCTGGCCGAGAACCCTAGCGGC
ACAATCGTCGAGCTGGGTGCTGGTCTGGAAACTCAGTTCCATCGCCTCGATAACGGAACGGTTTTGTGGATATGCCTTGA
CCTTGACGAGGTCATCGCAGTGCGGGAAAAGTTCCTGGCTCCCACCGAGCGGTGCCGTTACATTGCTGCGGATGCCTGCG
ACGTGTCATGGTTCGAGCAGGTGGGCCCCGGCCCGGTTCTCATTACCGCGCAGAGCTTTCTGATGTTCTTACACGAAGAG
CAGGCTCGGCACTTGCTTGTCGCCATCATCGACCGGTTTCCGGGCGTGGAAATTGTCTTCGACACGATTTCGCCTGCCAT
ATCCCAAAAAATGGTCAAGGGCTACAAGCCGACCGAAAACTACGAGTTTCCCGCTGCGCCATGGGGTATCAAGTGGGATG
CCATCGCCCCGTTACTACGGCGATGGCATACAGGTATTTCCAGCGTCGAGGTCCAGAGTTTCGGTGCCGTCCACGGAGCC
TTGAATGTCATCAAGCCGCTGTTCCTGCGGATTCCCGCGCTGCGCGGCATGTTGCCGGCGGTGGCGCATCTGAAAGCGTA
A

Upstream 100 bases:

>100_bases
CGTCAGGAAGCGCGCCGGCGCCGCCGCGCACGGTAGGCGTGCGGGTGAATGTCGTACTTGTACCGATAGTTCTTTCAGTA
CTGATGTGAGGAGTGACGAA

Downstream 100 bases:

>100_bases
GGCAGATAGTCCCCTCGTCTGGGTGGCGAGCTCTGTTATCGAATCATCGAAAAATGCTGGCTATCAGTCGGGTTCGTAAA
TCGGCGTGTTGGGCAGCGGC

Product: putative O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MAQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHGEKSRIFDVVVRQWLAENPSG
TIVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLAPTERCRYIAADACDVSWFEQVGPGPVLITAQSFLMFLHEE
QARHLLVAIIDRFPGVEIVFDTISPAISQKMVKGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVEVQSFGAVHGA
LNVIKPLFLRIPALRGMLPAVAHLKA

Sequences:

>Translated_266_residues
MAQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHGEKSRIFDVVVRQWLAENPSG
TIVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLAPTERCRYIAADACDVSWFEQVGPGPVLITAQSFLMFLHEE
QARHLLVAIIDRFPGVEIVFDTISPAISQKMVKGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVEVQSFGAVHGA
LNVIKPLFLRIPALRGMLPAVAHLKA
>Mature_265_residues
AQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHGEKSRIFDVVVRQWLAENPSGT
IVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLAPTERCRYIAADACDVSWFEQVGPGPVLITAQSFLMFLHEEQ
ARHLLVAIIDRFPGVEIVFDTISPAISQKMVKGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVEVQSFGAVHGAL
NVIKPLFLRIPALRGMLPAVAHLKA

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 29763; Mature: 29631

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHG
CCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCCC
EKSRIFDVVVRQWLAENPSGTIVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLA
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCCCCEEEEEEECHHHHHHHHHHHCC
PTERCRYIAADACDVSWFEQVGPGPVLITAQSFLMFLHEEQARHLLVAIIDRFPGVEIVF
HHHHHHEEECCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEH
DTISPAISQKMVKGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVEVQSFGAVHGA
HHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LNVIKPLFLRIPALRGMLPAVAHLKA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHG
CCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCCC
EKSRIFDVVVRQWLAENPSGTIVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLA
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCCCCEEEEEEECHHHHHHHHHHHCC
PTERCRYIAADACDVSWFEQVGPGPVLITAQSFLMFLHEEQARHLLVAIIDRFPGVEIVF
HHHHHHEEECCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEH
DTISPAISQKMVKGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVEVQSFGAVHGA
HHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LNVIKPLFLRIPALRGMLPAVAHLKA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]