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The map label for this gene is fmt [H]

Identifier: 169629346

GI number: 169629346

Start: 2304472

End: 2305410

Strand: Direct

Name: fmt [H]

Synonym: MAB_2260

Alternate gene names: 169629346

Gene position: 2304472-2305410 (Clockwise)

Preceding gene: 169629345

Following gene: 169629359

Centisome position: 45.48

GC content: 59.96

Gene sequence:

>939_bases
ATGCGCGTAGTGTTTTTCGGGTATCAAACATGGGGTTACCGGACTTTGCAGGCATTGATAGATCTGGGGCATGAGATCGT
ACTTGCGGTCACTCATCCCATGAGCGAGGATGCCTACAAAGCGATTTGGGCAGCTCCGGTCGAGGAACTCGCGCGCGAAC
ACGGCATACCTGCGCATTTCACCAAGAGGGTCGACGCCGAGACGATCGATCTGGTCCGGAGTGTCGATCCAGACGTCATC
GTCGTCAATAGCTGGTACAACCGGATGCCGGTCGAGCTATACGATTTACCGCCATACGGCACCTTGAACTTCCACGATTC
GTTGCTGCCGAAATTTACTGGATTCTCACCGGTGCTATGGGCATTGATCAGTGGTGAGTCCGAGTTTGGACTGACCGTGC
ATCGAATGGACAGCGGGCTCGATACGGGTGACATCCTGGTACAGCGTTCACTGCCGATCGGCCCCACCGATACCGGCACC
GAGTTGGTGCTGCGAGGGATGGAACTGATCCCGCGTGTGCTGGCGGAGGCGCTGAATGCGCTGGAGTCCGGCTCGGCCGC
CTGGCGGCCGCAGAACAAGGCTGAACGAACCTTCTGCCACAAGCGATCTGAGCAGGATAGCGCGCTGGACTGGGCGTGGC
CGGCGGAGGATCTGGAACGGTTTGTTCGTGCGCTGTCCGAGCCGTATCCTCGTGCGTTCGCTTTCTACAATACGGAGCGG
ATAGAGGTTTTGGAGGCGCGTGTGTCCGAGGCCCGCTACGGCGGCACGCCGGGGCGAGTGACGGTCCAGGAACAGGGCGG
CGCTGTGGTGTGCGGACCCGGCGCTCATCGCGCCGCAAACCGTGGATTGGTCATTACACGTATTCGGCGTGCTGACGGAA
GCGAAGTCAGTGGGGAAGAGTACTTTCGTCGCGGCGGATACCTAGACGGCGGCAACTGA

Upstream 100 bases:

>100_bases
GGGTGGCGAGCTCTGTTATCGAATCATCGAAAAATGCTGGCTATCAGTCGGGTTCGTAAATCGGCGTGTTGGGCAGCGGC
GAAGAATGGAAAGGAACGAT

Downstream 100 bases:

>100_bases
TCTCGCCGCAGCGCTGTGGGGGCGCTGTAGCACGGGATCGACCACGGGATCGACAGCGCCGCGGGCCGTGTCGGCCTAAT
GGGTGGCTGCGGCGATACGC

Product: putative formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRVVFFGYQTWGYRTLQALIDLGHEIVLAVTHPMSEDAYKAIWAAPVEELAREHGIPAHFTKRVDAETIDLVRSVDPDVI
VVNSWYNRMPVELYDLPPYGTLNFHDSLLPKFTGFSPVLWALISGESEFGLTVHRMDSGLDTGDILVQRSLPIGPTDTGT
ELVLRGMELIPRVLAEALNALESGSAAWRPQNKAERTFCHKRSEQDSALDWAWPAEDLERFVRALSEPYPRAFAFYNTER
IEVLEARVSEARYGGTPGRVTVQEQGGAVVCGPGAHRAANRGLVITRIRRADGSEVSGEEYFRRGGYLDGGN

Sequences:

>Translated_312_residues
MRVVFFGYQTWGYRTLQALIDLGHEIVLAVTHPMSEDAYKAIWAAPVEELAREHGIPAHFTKRVDAETIDLVRSVDPDVI
VVNSWYNRMPVELYDLPPYGTLNFHDSLLPKFTGFSPVLWALISGESEFGLTVHRMDSGLDTGDILVQRSLPIGPTDTGT
ELVLRGMELIPRVLAEALNALESGSAAWRPQNKAERTFCHKRSEQDSALDWAWPAEDLERFVRALSEPYPRAFAFYNTER
IEVLEARVSEARYGGTPGRVTVQEQGGAVVCGPGAHRAANRGLVITRIRRADGSEVSGEEYFRRGGYLDGGN
>Mature_312_residues
MRVVFFGYQTWGYRTLQALIDLGHEIVLAVTHPMSEDAYKAIWAAPVEELAREHGIPAHFTKRVDAETIDLVRSVDPDVI
VVNSWYNRMPVELYDLPPYGTLNFHDSLLPKFTGFSPVLWALISGESEFGLTVHRMDSGLDTGDILVQRSLPIGPTDTGT
ELVLRGMELIPRVLAEALNALESGSAAWRPQNKAERTFCHKRSEQDSALDWAWPAEDLERFVRALSEPYPRAFAFYNTER
IEVLEARVSEARYGGTPGRVTVQEQGGAVVCGPGAHRAANRGLVITRIRRADGSEVSGEEYFRRGGYLDGGN

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=323, Percent_Identity=26.9349845201238, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21614513, Length=325, Percent_Identity=24, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788589, Length=313, Percent_Identity=30.9904153354633, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1789683, Length=277, Percent_Identity=32.4909747292419, Blast_Score=140, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=260, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550868, Length=272, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571984, Length=211, Percent_Identity=26.5402843601896, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34760; Mature: 34760

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVFFGYQTWGYRTLQALIDLGHEIVLAVTHPMSEDAYKAIWAAPVEELAREHGIPAHF
CEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHH
TKRVDAETIDLVRSVDPDVIVVNSWYNRMPVELYDLPPYGTLNFHDSLLPKFTGFSPVLW
HHHCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCHHHHH
ALISGESEFGLTVHRMDSGLDTGDILVQRSLPIGPTDTGTELVLRGMELIPRVLAEALNA
HHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LESGSAAWRPQNKAERTFCHKRSEQDSALDWAWPAEDLERFVRALSEPYPRAFAFYNTER
HHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
IEVLEARVSEARYGGTPGRVTVQEQGGAVVCGPGAHRAANRGLVITRIRRADGSEVSGEE
HHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCHHCCCCEEEEEEECCCCCCCCHHH
YFRRGGYLDGGN
HHHHCCCCCCCC
>Mature Secondary Structure
MRVVFFGYQTWGYRTLQALIDLGHEIVLAVTHPMSEDAYKAIWAAPVEELAREHGIPAHF
CEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHH
TKRVDAETIDLVRSVDPDVIVVNSWYNRMPVELYDLPPYGTLNFHDSLLPKFTGFSPVLW
HHHCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCHHHHH
ALISGESEFGLTVHRMDSGLDTGDILVQRSLPIGPTDTGTELVLRGMELIPRVLAEALNA
HHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LESGSAAWRPQNKAERTFCHKRSEQDSALDWAWPAEDLERFVRALSEPYPRAFAFYNTER
HHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
IEVLEARVSEARYGGTPGRVTVQEQGGAVVCGPGAHRAANRGLVITRIRRADGSEVSGEE
HHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCHHCCCCEEEEEEECCCCCCCCHHH
YFRRGGYLDGGN
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA