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The map label for this gene is tycC [H]

Identifier: 169629341

GI number: 169629341

Start: 2285340

End: 2288708

Strand: Direct

Name: tycC [H]

Synonym: MAB_2255

Alternate gene names: 169629341

Gene position: 2285340-2288708 (Clockwise)

Preceding gene: 169629339

Following gene: 169629342

Centisome position: 45.1

GC content: 62.6

Gene sequence:

>3369_bases
ATGTCGACGTCCCGGGCAGGCAACGCGGCCGCTGCGGAGCGCTTGCGATTGCTACGGGCAGTACTGGCCGAACGTGGGCT
CACGGGCTCGGCCGCTGGCGCCCAGAACACGACTGTTCAGGCGCGATCGCCCATGGCTGTGGTCCCCCTATCTTCAACGC
AGCGGCGGATGTGGTTCGCGCAAACCCTTTTTCCCGACGAGGGTGCCTACAACATGCCGGTCGGTCTCCGAATTGATGGA
CCGCTCGATGTCGGCGCGTTGTGTAGGAGTCTTGGCAAGTTGGTCGAACGGCACGCCATTTTGCGGACGCGTTGCGGGCA
TGGCGCTGATGGCGAGCTGATACAACTGATCGGGGACGCTGCAGATTTCACGCTTTCGGTGGTGGACATCGATGTCGATG
CGTCGGGGCGACTTGAGGATGCGGTGCACACCCGCACGCGGGAGATTGTTGATCGCCCTTTTGATCTGGCTTTGGAAAAC
CCGGTGCGAGCGGAGCTTTTGCGGGCCTCAGCCCATACGCATTTTCTGATTCTGGTGCTGCACCATGTCGCCGCGGACGA
GATCACCTGGGACCTGTTGTTCGCTGATCTGTCCGGACAGTACGCCTTCGAGACGGGTCAGAGTGGCTCTGCGCCAACGG
CTCCGGACCTCGAATACGCGGACTACGCCGTGTGGGAACAACAACGACTCAGGCGCGGTGACCTCGACGGTCAGCTGCAG
TACTGGGTCGACCGATTTACCCCAGCGCCGGCCATTGTTGGCTTTCCGGTTACGGCGCAGTCTTCAGGGCAACGCGGCAC
AACCAGTGGTCGGTGCCGGCATGCTTTGCCGGATGCCGCTGTCGCCGGACTGCGAGATCTTGCTGAGGAGCACAAGACCA
CGCCGTTCACGATTGCGCTTGCGGGACTGGCCGCGGTACTGCACCGGTATACGGAGGCAACGGATGTGGTGATCGGGATA
CCGGCACTGATCCGCGATGCGTCCGAAATCGAAGGTGTGTGGGGAAATTTCACCAATACCCTGGCGATGCGGCTGAACGT
CGACGGCGAGACCACCTTTATGGATCTGCTGGGGCGCGCCCGAACGGCGTTCTTCGAAGCCTGCGACAACCGCGACATCC
CCTTCGAGACGATCATTGAACGGGTTGCACCGCAAAGAACGACCGGCCGTTCACCATTGTTCGAGGTCATGTTCGCGGCG
ACTCGCTCGGTCACGAGCCAATTGCAGCTAGCCGGAACGACGGCCACTGATCTGAGACTTCGCAATGCGACGTCGATGTT
CGACCTCGCGATCGACCTGGTCGACGGGCAAGTCCTGGCGGCCAGCTTCCGCACCGGAAAGTACGCGCCGGAATTCATAC
AGCAAGTGTTGGAGCATCTTGCGTCGGTGTTGGCCCATGGAGTGTCGAATCCAGGGCAGTGTGTGCGTGATTTCCCGTTA
CTCACCGAGCGTCAACACCAGCGCATTGTTCACGACTGGAATGCCACCGACGACACCCGCCATCTCGTCAGTGCACCACT
GCACAAACTTTTTGAGCGGCATGTCCGACAGAATCCGGATGCCCTGGCGGTCGTGACCGAGGACGCGCACCTTAGCTACG
GTCAGCTGGATGAGCATGCCGGACGGCTGGCCTCGTTGTTGCGTTCCCTCGACATCGGTTACGACAGTCTTGTCGGGATC
AATATGGAGCGGTCGACGAACCTCGCGGTGGCCTTGCTTGCCGTATTGAAGACCGGTGCCGCGTTTGTGCCGCTGGAACC
GGCCTGGCCGCCGAGCCGGATAGCCGAGGTTTGCGCAAGCGCCCGCCTGGCGGCGGTACTCACCCATGGTGGCCCGGCGC
TACGGCTGCCGAGCCTGGAGATACCGGTGCTGAGTCTGGATGAGAATCATCCGAGCGCAAGGGCTGCGCGCGCCCCTTCG
TTCGGCTCTCAGATGTCCGACCTTGCGTACGTGGTCTTCACGTCCGGTTCCACGGGCGCTCCGAAGGGGGTGATGGTGAC
ACATGCAGGAATCTGTAACCGACTGTTGTGGCAAGCCGATGTCCTGGGATTCGGCGCCGGCGATGTCGCACTGCACAAGT
CGTCACTGGGATTCGACATGGGAATCAACGAGATATTGCTGCCGCTGGTCAGCGGTGGCAGGGTGGTGCTGCCCAAGCCA
GGGGCAGAGTCGGACCCTGCGTACTTGCTCGATCTGATCGGACGCACCGGTGTGACGTTCATCGATCTGGTGCCCTCACT
GCTGGACCCCATGCTGGATCGGCCCGAGTTCGCCGACGCGACACGTTCGTTGGCTTCGGTGTGGACCGGCGGCGAGGTGC
TGACCCCCGAGCTGCTTGAGCGGTTTCTTTCTGCCTGCGCGGTTCCCATGTATCACGGGTACGGGCCCACCGAAGCAACC
GTGGCGTGTACCTACGAGATCTACCGGTCCGGTTCACGCAGACGTGGTGTGACTATCGGCAGCCCGATTGGCAACAGCCA
GGTCTTCATCCTCGACACGTTGCTACGCCCGGTGCCGCCCGGTGTTGCCGGTGAGTTGTATATCGGAGGCGTGCAACTGG
CACGCGGATACGTCGAAGATCCGGTGCGCACCGCTGAGCGGTTCGTCGCAGACCCGGTGTCCGGCACCCCGGGCGCTCGC
ATCTACCGGACCGGCGACCAGGCACGCTTTCTGCCCGACGGCACCATCGAGTTCCTTGGGCGGGTAGACAATCAGTTGAA
AATCCGGGGTCGCAGGATCGCCCCGGAAGAGATCGAGAATGCGCTTACCTCGCATCCCTGCGTCCGTCGCGCCGTGGTCA
TGGCGCAAGGCGACCGATTGGTCGGCTACTGTGCCAGCGATGACCCGGCGCTGACCTGGCTGCAACTGCGTGACTGGCTA
CGCACACGATTGCCGGAGCATCTCGTGCCGCCGACCGGAACCATCCTCGACACGTTGCCGGAGCTGGCGTCGGGCAAGAT
CGATCGCGCTGCGATACAGCGAATTCCCATCGAGGTGAGCGCAGCGATCGTGCCCTACCTCGAACCGAGGTACGCCATGG
AGCGGGTGTTGGTCGACCTGTGGCGCGTGGTGCTCAAGGTTCCCCGCATCGGCGTTGACGACAACTTTTTCGACATGGGC
GGGCATTCGCTGTTACTGGCTCGCGTTCAGGCCAAACTTTCGGAGCAGCTTGGTTTTTCTGTATCGCTGCTCGATTTGTA
CGCACATCCGACCGTCGCGGAGCTCGCCACGTACCTGAACGCCGCCCGCGACGGGGGCACCGAATCCGAATCAATGGACG
GCGGCGGGCTCGTCGCCGCGCGCACTCGAGCCGAGCGTGGGCGTGATGCCCGGGCTCAGCGTCTATCACAGCAACGGCAA
AGGCGGTAG

Upstream 100 bases:

>100_bases
TGCCCCGAAGCACTTTCGGCTCTGCGTCCAACGCTGTACGAACCCGATCGTGCAAACCCGCTGTGATCATGCGGCGTCAA
TGGACAAAGGAGACATAAGA

Downstream 100 bases:

>100_bases
ATCCAGTGATGCAGCACTCTTCAACAGCGGCGGAACTTCAGCGCAAATGGCTGCGGGGGGGAGCTTTCGAACCCGATCGG
CATCCCGCGTTGGTGGTGTT

Product: non-ribosomal peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1122; Mature: 1121

Protein sequence:

>1122_residues
MSTSRAGNAAAAERLRLLRAVLAERGLTGSAAGAQNTTVQARSPMAVVPLSSTQRRMWFAQTLFPDEGAYNMPVGLRIDG
PLDVGALCRSLGKLVERHAILRTRCGHGADGELIQLIGDAADFTLSVVDIDVDASGRLEDAVHTRTREIVDRPFDLALEN
PVRAELLRASAHTHFLILVLHHVAADEITWDLLFADLSGQYAFETGQSGSAPTAPDLEYADYAVWEQQRLRRGDLDGQLQ
YWVDRFTPAPAIVGFPVTAQSSGQRGTTSGRCRHALPDAAVAGLRDLAEEHKTTPFTIALAGLAAVLHRYTEATDVVIGI
PALIRDASEIEGVWGNFTNTLAMRLNVDGETTFMDLLGRARTAFFEACDNRDIPFETIIERVAPQRTTGRSPLFEVMFAA
TRSVTSQLQLAGTTATDLRLRNATSMFDLAIDLVDGQVLAASFRTGKYAPEFIQQVLEHLASVLAHGVSNPGQCVRDFPL
LTERQHQRIVHDWNATDDTRHLVSAPLHKLFERHVRQNPDALAVVTEDAHLSYGQLDEHAGRLASLLRSLDIGYDSLVGI
NMERSTNLAVALLAVLKTGAAFVPLEPAWPPSRIAEVCASARLAAVLTHGGPALRLPSLEIPVLSLDENHPSARAARAPS
FGSQMSDLAYVVFTSGSTGAPKGVMVTHAGICNRLLWQADVLGFGAGDVALHKSSLGFDMGINEILLPLVSGGRVVLPKP
GAESDPAYLLDLIGRTGVTFIDLVPSLLDPMLDRPEFADATRSLASVWTGGEVLTPELLERFLSACAVPMYHGYGPTEAT
VACTYEIYRSGSRRRGVTIGSPIGNSQVFILDTLLRPVPPGVAGELYIGGVQLARGYVEDPVRTAERFVADPVSGTPGAR
IYRTGDQARFLPDGTIEFLGRVDNQLKIRGRRIAPEEIENALTSHPCVRRAVVMAQGDRLVGYCASDDPALTWLQLRDWL
RTRLPEHLVPPTGTILDTLPELASGKIDRAAIQRIPIEVSAAIVPYLEPRYAMERVLVDLWRVVLKVPRIGVDDNFFDMG
GHSLLLARVQAKLSEQLGFSVSLLDLYAHPTVAELATYLNAARDGGTESESMDGGGLVAARTRAERGRDARAQRLSQQRQ
RR

Sequences:

>Translated_1122_residues
MSTSRAGNAAAAERLRLLRAVLAERGLTGSAAGAQNTTVQARSPMAVVPLSSTQRRMWFAQTLFPDEGAYNMPVGLRIDG
PLDVGALCRSLGKLVERHAILRTRCGHGADGELIQLIGDAADFTLSVVDIDVDASGRLEDAVHTRTREIVDRPFDLALEN
PVRAELLRASAHTHFLILVLHHVAADEITWDLLFADLSGQYAFETGQSGSAPTAPDLEYADYAVWEQQRLRRGDLDGQLQ
YWVDRFTPAPAIVGFPVTAQSSGQRGTTSGRCRHALPDAAVAGLRDLAEEHKTTPFTIALAGLAAVLHRYTEATDVVIGI
PALIRDASEIEGVWGNFTNTLAMRLNVDGETTFMDLLGRARTAFFEACDNRDIPFETIIERVAPQRTTGRSPLFEVMFAA
TRSVTSQLQLAGTTATDLRLRNATSMFDLAIDLVDGQVLAASFRTGKYAPEFIQQVLEHLASVLAHGVSNPGQCVRDFPL
LTERQHQRIVHDWNATDDTRHLVSAPLHKLFERHVRQNPDALAVVTEDAHLSYGQLDEHAGRLASLLRSLDIGYDSLVGI
NMERSTNLAVALLAVLKTGAAFVPLEPAWPPSRIAEVCASARLAAVLTHGGPALRLPSLEIPVLSLDENHPSARAARAPS
FGSQMSDLAYVVFTSGSTGAPKGVMVTHAGICNRLLWQADVLGFGAGDVALHKSSLGFDMGINEILLPLVSGGRVVLPKP
GAESDPAYLLDLIGRTGVTFIDLVPSLLDPMLDRPEFADATRSLASVWTGGEVLTPELLERFLSACAVPMYHGYGPTEAT
VACTYEIYRSGSRRRGVTIGSPIGNSQVFILDTLLRPVPPGVAGELYIGGVQLARGYVEDPVRTAERFVADPVSGTPGAR
IYRTGDQARFLPDGTIEFLGRVDNQLKIRGRRIAPEEIENALTSHPCVRRAVVMAQGDRLVGYCASDDPALTWLQLRDWL
RTRLPEHLVPPTGTILDTLPELASGKIDRAAIQRIPIEVSAAIVPYLEPRYAMERVLVDLWRVVLKVPRIGVDDNFFDMG
GHSLLLARVQAKLSEQLGFSVSLLDLYAHPTVAELATYLNAARDGGTESESMDGGGLVAARTRAERGRDARAQRLSQQRQ
RR
>Mature_1121_residues
STSRAGNAAAAERLRLLRAVLAERGLTGSAAGAQNTTVQARSPMAVVPLSSTQRRMWFAQTLFPDEGAYNMPVGLRIDGP
LDVGALCRSLGKLVERHAILRTRCGHGADGELIQLIGDAADFTLSVVDIDVDASGRLEDAVHTRTREIVDRPFDLALENP
VRAELLRASAHTHFLILVLHHVAADEITWDLLFADLSGQYAFETGQSGSAPTAPDLEYADYAVWEQQRLRRGDLDGQLQY
WVDRFTPAPAIVGFPVTAQSSGQRGTTSGRCRHALPDAAVAGLRDLAEEHKTTPFTIALAGLAAVLHRYTEATDVVIGIP
ALIRDASEIEGVWGNFTNTLAMRLNVDGETTFMDLLGRARTAFFEACDNRDIPFETIIERVAPQRTTGRSPLFEVMFAAT
RSVTSQLQLAGTTATDLRLRNATSMFDLAIDLVDGQVLAASFRTGKYAPEFIQQVLEHLASVLAHGVSNPGQCVRDFPLL
TERQHQRIVHDWNATDDTRHLVSAPLHKLFERHVRQNPDALAVVTEDAHLSYGQLDEHAGRLASLLRSLDIGYDSLVGIN
MERSTNLAVALLAVLKTGAAFVPLEPAWPPSRIAEVCASARLAAVLTHGGPALRLPSLEIPVLSLDENHPSARAARAPSF
GSQMSDLAYVVFTSGSTGAPKGVMVTHAGICNRLLWQADVLGFGAGDVALHKSSLGFDMGINEILLPLVSGGRVVLPKPG
AESDPAYLLDLIGRTGVTFIDLVPSLLDPMLDRPEFADATRSLASVWTGGEVLTPELLERFLSACAVPMYHGYGPTEATV
ACTYEIYRSGSRRRGVTIGSPIGNSQVFILDTLLRPVPPGVAGELYIGGVQLARGYVEDPVRTAERFVADPVSGTPGARI
YRTGDQARFLPDGTIEFLGRVDNQLKIRGRRIAPEEIENALTSHPCVRRAVVMAQGDRLVGYCASDDPALTWLQLRDWLR
TRLPEHLVPPTGTILDTLPELASGKIDRAAIQRIPIEVSAAIVPYLEPRYAMERVLVDLWRVVLKVPRIGVDDNFFDMGG
HSLLLARVQAKLSEQLGFSVSLLDLYAHPTVAELATYLNAARDGGTESESMDGGGLVAARTRAERGRDARAQRLSQQRQR
R

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=583, Percent_Identity=24.5283018867925, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI38505220, Length=563, Percent_Identity=23.9786856127886, Blast_Score=107, Evalue=7e-23,
Organism=Homo sapiens, GI42544132, Length=381, Percent_Identity=24.1469816272966, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI122937307, Length=368, Percent_Identity=25.8152173913043, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=368, Percent_Identity=24.7282608695652, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI157311622, Length=368, Percent_Identity=24.7282608695652, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI156151445, Length=558, Percent_Identity=23.2974910394265, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI58082049, Length=368, Percent_Identity=24.7282608695652, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI42794756, Length=506, Percent_Identity=26.6798418972332, Blast_Score=93, Evalue=2e-18,
Organism=Homo sapiens, GI42794760, Length=506, Percent_Identity=26.6798418972332, Blast_Score=93, Evalue=2e-18,
Organism=Homo sapiens, GI42794758, Length=506, Percent_Identity=26.6798418972332, Blast_Score=93, Evalue=2e-18,
Organism=Homo sapiens, GI57165410, Length=525, Percent_Identity=24.5714285714286, Blast_Score=88, Evalue=5e-17,
Organism=Homo sapiens, GI115511026, Length=371, Percent_Identity=23.989218328841, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI57165412, Length=525, Percent_Identity=24.7619047619048, Blast_Score=87, Evalue=1e-16,
Organism=Homo sapiens, GI13375727, Length=380, Percent_Identity=24.7368421052632, Blast_Score=74, Evalue=9e-13,
Organism=Escherichia coli, GI1786801, Length=1074, Percent_Identity=29.3296089385475, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=25.6120527306968, Blast_Score=110, Evalue=7e-25,
Organism=Escherichia coli, GI145693145, Length=536, Percent_Identity=24.0671641791045, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1788107, Length=537, Percent_Identity=23.8361266294227, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI221142682, Length=531, Percent_Identity=23.1638418079096, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17556356, Length=1053, Percent_Identity=22.1272554605888, Blast_Score=155, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17550940, Length=977, Percent_Identity=20.2661207778915, Blast_Score=117, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=476, Percent_Identity=24.7899159663866, Blast_Score=104, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=390, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=511, Percent_Identity=22.5048923679061, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=530, Percent_Identity=23.9622641509434, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=373, Percent_Identity=25.7372654155496, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=371, Percent_Identity=23.7196765498652, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=371, Percent_Identity=23.7196765498652, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=360, Percent_Identity=25.8333333333333, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=371, Percent_Identity=23.7196765498652, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=493, Percent_Identity=23.1237322515213, Blast_Score=78, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32564422, Length=512, Percent_Identity=24.4140625, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564420, Length=512, Percent_Identity=24.4140625, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=948, Percent_Identity=22.7848101265823, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319699, Length=368, Percent_Identity=26.9021739130435, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319264, Length=566, Percent_Identity=24.2049469964664, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24648676, Length=656, Percent_Identity=29.5731707317073, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24581924, Length=350, Percent_Identity=26.8571428571429, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648260, Length=525, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356441, Length=519, Percent_Identity=22.5433526011561, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281365686, Length=508, Percent_Identity=21.8503937007874, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667955, Length=575, Percent_Identity=24.1739130434783, Blast_Score=82, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859661, Length=471, Percent_Identity=24.203821656051, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI62472339, Length=544, Percent_Identity=24.0808823529412, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24667959, Length=382, Percent_Identity=26.1780104712042, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 121795; Mature: 121664

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSRAGNAAAAERLRLLRAVLAERGLTGSAAGAQNTTVQARSPMAVVPLSSTQRRMWFA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHH
QTLFPDEGAYNMPVGLRIDGPLDVGALCRSLGKLVERHAILRTRCGHGADGELIQLIGDA
HHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
ADFTLSVVDIDVDASGRLEDAVHTRTREIVDRPFDLALENPVRAELLRASAHTHFLILVL
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
HHVAADEITWDLLFADLSGQYAFETGQSGSAPTAPDLEYADYAVWEQQRLRRGDLDGQLQ
HHHHHHHHHHEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
YWVDRFTPAPAIVGFPVTAQSSGQRGTTSGRCRHALPDAAVAGLRDLAEEHKTTPFTIAL
HHHHHCCCCCCEEECCEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
AGLAAVLHRYTEATDVVIGIPALIRDASEIEGVWGNFTNTLAMRLNVDGETTFMDLLGRA
HHHHHHHHHHHHHHHEEEECHHHHCCHHHHCCHHCCCCEEEEEEEECCCCHHHHHHHHHH
RTAFFEACDNRDIPFETIIERVAPQRTTGRSPLFEVMFAATRSVTSQLQLAGTTATDLRL
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEE
RNATSMFDLAIDLVDGQVLAASFRTGKYAPEFIQQVLEHLASVLAHGVSNPGQCVRDFPL
CCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCH
LTERQHQRIVHDWNATDDTRHLVSAPLHKLFERHVRQNPDALAVVTEDAHLSYGQLDEHA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
GRLASLLRSLDIGYDSLVGINMERSTNLAVALLAVLKTGAAFVPLEPAWPPSRIAEVCAS
HHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
ARLAAVLTHGGPALRLPSLEIPVLSLDENHPSARAARAPSFGSQMSDLAYVVFTSGSTGA
HHHHHHEECCCCEEECCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCC
PKGVMVTHAGICNRLLWQADVLGFGAGDVALHKSSLGFDMGINEILLPLVSGGRVVLPKP
CCCEEEECHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCEEEECCC
GAESDPAYLLDLIGRTGVTFIDLVPSLLDPMLDRPEFADATRSLASVWTGGEVLTPELLE
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECHHHHH
RFLSACAVPMYHGYGPTEATVACTYEIYRSGSRRRGVTIGSPIGNSQVFILDTLLRPVPP
HHHHHHCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCEECCCCCCCCEEEEEHHHHCCCC
GVAGELYIGGVQLARGYVEDPVRTAERFVADPVSGTPGARIYRTGDQARFLPDGTIEFLG
CCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECCCHHHHHHH
RVDNQLKIRGRRIAPEEIENALTSHPCVRRAVVMAQGDRLVGYCASDDPALTWLQLRDWL
HCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
RTRLPEHLVPPTGTILDTLPELASGKIDRAAIQRIPIEVSAAIVPYLEPRYAMERVLVDL
HHHCCHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCEEEEHHCCCCCCHHHHHHHHHHHH
WRVVLKVPRIGVDDNFFDMGGHSLLLARVQAKLSEQLGFSVSLLDLYAHPTVAELATYLN
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHHH
AARDGGTESESMDGGGLVAARTRAERGRDARAQRLSQQRQRR
HHHCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSRAGNAAAAERLRLLRAVLAERGLTGSAAGAQNTTVQARSPMAVVPLSSTQRRMWFA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHH
QTLFPDEGAYNMPVGLRIDGPLDVGALCRSLGKLVERHAILRTRCGHGADGELIQLIGDA
HHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
ADFTLSVVDIDVDASGRLEDAVHTRTREIVDRPFDLALENPVRAELLRASAHTHFLILVL
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
HHVAADEITWDLLFADLSGQYAFETGQSGSAPTAPDLEYADYAVWEQQRLRRGDLDGQLQ
HHHHHHHHHHEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
YWVDRFTPAPAIVGFPVTAQSSGQRGTTSGRCRHALPDAAVAGLRDLAEEHKTTPFTIAL
HHHHHCCCCCCEEECCEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
AGLAAVLHRYTEATDVVIGIPALIRDASEIEGVWGNFTNTLAMRLNVDGETTFMDLLGRA
HHHHHHHHHHHHHHHEEEECHHHHCCHHHHCCHHCCCCEEEEEEEECCCCHHHHHHHHHH
RTAFFEACDNRDIPFETIIERVAPQRTTGRSPLFEVMFAATRSVTSQLQLAGTTATDLRL
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEE
RNATSMFDLAIDLVDGQVLAASFRTGKYAPEFIQQVLEHLASVLAHGVSNPGQCVRDFPL
CCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCH
LTERQHQRIVHDWNATDDTRHLVSAPLHKLFERHVRQNPDALAVVTEDAHLSYGQLDEHA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
GRLASLLRSLDIGYDSLVGINMERSTNLAVALLAVLKTGAAFVPLEPAWPPSRIAEVCAS
HHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
ARLAAVLTHGGPALRLPSLEIPVLSLDENHPSARAARAPSFGSQMSDLAYVVFTSGSTGA
HHHHHHEECCCCEEECCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCC
PKGVMVTHAGICNRLLWQADVLGFGAGDVALHKSSLGFDMGINEILLPLVSGGRVVLPKP
CCCEEEECHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCEEEECCC
GAESDPAYLLDLIGRTGVTFIDLVPSLLDPMLDRPEFADATRSLASVWTGGEVLTPELLE
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECHHHHH
RFLSACAVPMYHGYGPTEATVACTYEIYRSGSRRRGVTIGSPIGNSQVFILDTLLRPVPP
HHHHHHCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCEECCCCCCCCEEEEEHHHHCCCC
GVAGELYIGGVQLARGYVEDPVRTAERFVADPVSGTPGARIYRTGDQARFLPDGTIEFLG
CCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECCCHHHHHHH
RVDNQLKIRGRRIAPEEIENALTSHPCVRRAVVMAQGDRLVGYCASDDPALTWLQLRDWL
HCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
RTRLPEHLVPPTGTILDTLPELASGKIDRAAIQRIPIEVSAAIVPYLEPRYAMERVLVDL
HHHCCHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCEEEEHHCCCCCCHHHHHHHHHHHH
WRVVLKVPRIGVDDNFFDMGGHSLLLARVQAKLSEQLGFSVSLLDLYAHPTVAELATYLN
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHHH
AARDGGTESESMDGGGLVAARTRAERGRDARAQRLSQQRQRR
HHHCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]