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The map label for this gene is lgrC [H]

Identifier: 169629334

GI number: 169629334

Start: 2276108

End: 2280484

Strand: Direct

Name: lgrC [H]

Synonym: MAB_2248

Alternate gene names: 169629334

Gene position: 2276108-2280484 (Clockwise)

Preceding gene: 169629332

Following gene: 169629335

Centisome position: 44.92

GC content: 63.7

Gene sequence:

>4377_bases
GTGCGCACCGTGAGCGATGGTGACGTCGAGGTGGGCGTTACCAGCGGGGAAGCGCCGGTAGGCCTCGGTATAGCCGCGAT
GCCCCTGTCCGCGGGGCAGCACCGTATCTGGTTCGCACACGGTGTGACGCCAGTTCTGATGAACCTGTGCCGGTCCTATC
GGCTCCACGGTGAACTCGATGTAGACAAGCTGCGTGCGGCGGTCGCCGCGGTCGTGCTTCGTCACGCGGCGCTGCGCACC
ACGGTCCATGCCGGTGCCGATGGCCATCCGGTCGCCGTGCTGCACAGCGATCTGCAGGCTCGATGGATCGAGCACGATGT
GACCGACCTTGGCGGTACCGCACAGGAGCTGCGGCTGGCCGTGCTGGCGCAGCGTGAATACGGCACCGCGTTCGATCTGG
CCACGGAAGCGCCATTGCGTGTCACCGTCATCCGTACCGGCTCGGCGGAGTATGTGATGCTTGTGGTCGCCCACCGCATT
GGCTGGGATGACGAATCATGGCAGGTCTTTCTGGCCGATTTGACCGCAGCCTATGTCCACGGCGGTATCTCGGAGCCGCT
GTCCTCGGCGCCGAAGCAGGGCGGACCCGGCGATGCGGCAGTGGACTATTGGCGCGAGGAACTGTCGAATCCCGCTGAAC
CGTTAGAGCTTCCGGGGCCCAACGGTGCGGTGGTGCCAACCGATTGGAAGGCGGCGCGTTGTACCGCACATCTTTCCGTA
TCGGTGATGGAGCAGGTCGAGCGACTTGCGCGCGATTCGGGTTCCACGCCCCATGCGGTGCTGTTGGCGGCGTATTCGGT
TCTACTGCATCGGTACACACACGCCAATGACTTCATCGTGGCCTCGCCGGTGCCTGCCCTCGATCCCCATGCGCGTGGCC
GCATCGGGCACTTCGGCAACGTCCTCCCACTGCGTATGCGGCCACGCGCTGACGAAAGCTTCAAGGATCTGTTGGCCCGG
GTGCGGCGGACCACCCTGGATGGGATGGCGCATCAGGGAGTCAGTCTGGATCGCGTGGTACCGCGAGTTGGTTTCTCCAT
GGCTACCGATTCTGCCGAGTTGTTCTGTCCGCCCGGAATCCGTTGTGAAAAAGCGGCATTCGAAAGCCATGTGGCATATG
TTCCACTCGGTTTGACCGTGGAGGTGAAGTCCGGCGGCGCTGACGTGGTGGCCGAGTATCTGGTCACGGTGCTGGACGAG
CGGATGGCTACGCAGCTGCTGCGGCATTTTGCCAATGTGCTCGAAGCCGTACTGGCAGATCCGGACCGCATGGTGGGCGC
CGTGGATCTCATGGATGACCGTGAGGCGCAGTGGTTGTGGGCCGCATCGTCGGGTGAACGGTTCGAAGCGCCGCCTGCCA
CCCTCGGCGAACTGGTGGCCGAGCGGGCGGGTGCACAGCCAGATGCCGTCGCGGTCGTGTACGAGGGGCGTCATTACTCG
TACCGGGAGACCAATGATTTGGCGAATCGATTGGCGCACTGGATCATCGAGCAGGGGATCGGTACAGAGGATCACGTCGC
GGTTCTTCTCGACAAGTCCCCAGACTTGATCATCACCGCGCTGGCCATCGCCAAGGCGGGCGCGGTATACCTGCCAATCG
ATCCGGAGTATCCCCCCGACCGCATTGCGCATATTCTTGCCGACGCACAGCCCCGGCTGGTGATCCGGGAGCCGGTGACC
GGTCTCGATCAGTTCGATGCCCGCGAACCGGTTGACTCCGATCGGGTGCGGCCATTGACGCCAGACAATGCCGCCTACTT
GATCTATACATCCGGTTCAACCGGCATGCCTAAGGGCGTAACGGTTACGCACCGCCCTCTTACCGAGTACTTCAACTGGT
TCCGTGCCGAATATCGTGTCGGTGGATCAGATCGCGTGCTACAGGTGGGGTCGCCGAGTTTCGACGTGTCGATAGGGGAG
ATCTTCGGGATTCTCAGTTGTGGTGGACGCTTGGTCATTCCGCGTCCGGGCGGGCTCACCGACGTCGCCTATCTGACGGC
CCTGTTGAACAGTGAGGCCGTCACCTCGATGCACATGGTGCCCTCGCTGCTGGGGCTCATCTTGTCACTTCCGGGAGTGA
CGCAGTGGAAATCGCTACGCCGCGTGCCGGTAGGCGGCGAGGCACTGCCGGGGCCGGTTGCCGACAAATTCCACGCCACC
TTTGATGCCTCGCTGCACAATTTTTACGGCCCGACGGAGGCCATCATCAACGCCTCGCGCTACAAGGTCCGTGGGATCCA
GGGCACGCGGACCGTACCGATCGGTACTCCCAAGATCAACACTCAGATTCACATTCTTGACGAGACTCTGCGCCCGGTTC
CGGTGGGTGCTATCGGTGAGATATACATCGCAGGAACGCATCTGGCGCGTGGATATCACCGCGCCCCTGCTCTTACCGCG
CAGCGCTTCATCGCCGACCCCTTTACTCCCGGGCAGCGGATGTATCGGTCCGGCGACCTGGCGCGCCGCAACGCCGGCGG
AGATGTGGAGTTCGTCGGGCGAGCCGACGAGCAGGTGAAGATCCGGGGATTCCGTGTCGAGCTCGGTGAGATCTCATCGG
CCATCGAGGTTGATCCCAGTGTGAGTCAGGCGCTGGTTGTGGTGGACGAACTGCCGCACCTCGGTAAGCGCCTGGTTGCT
TATCTGACACCGATCGGCGGACACGTGGTCGATATCGACCGGATCCGCTCCAGGATCTCGGCGGCCCTGCCCGACTACAT
GATTCCGGCCGCATACGTTGTGCTGGACGAGATTCCCATCACCCCGCACGGCAAGATCGACCGGGATGCGCTACCGGCAC
CCGACAGCGGGACCGTCACGGAACGGCGTGAGGCCCAAACACCGACACAACGTGCGGTATCCGTGCTTTTCGCGCAGGTA
CTCGGAACAGCCGTGGTGGGTATCGACGACTCGTTCGAGTCCCTCGGCGGCCATTCCTTGCTCGCGAGCAAGCTCTCTGC
CACGATTCTGTCCGAGTATGGAGTACGGATCGATATTCGCGAGATCCTGCGCCGGGGTACCGTCGCGAGCTTGGCCGAAC
TGATAGATCAGCACATGGGCAGCACAGCGGATTCGGTGGACAGTGCGCCCGAGGGCGAACCGATTCCGCTGCTGCCGGGC
GGGCACAGCCTCTACGAGTACGGAAACCCCCGCAGGCTCGCGGTGACCTGTGTCTTCCGCCTCCATGACGGCGTCAACCG
GGCCGCATTGGAGCAGCTGCTCGGCGCCGTTGTCGGAGAACATGAAGCACTGCACAGCCGGCTGGACCGAGAGAGCATGA
CGCTGGTGCCGCGCGCGCGCCCGGCGCTACGATTTGTCGAGATCGTCGCGGCGGATCCATCTGTCGCCGCAGCCGCGGAG
ATCGCGCGTGCAGTGGATCGCCTTGACCCGGAGCAAGGTTGGATGTTGTCGGCGGTGTGGCTGCACCCGGACAACGAGCC
GGGAGTTCTCATCCTGGCGGTGCACCACCTGGCGGCTGATCCCATTTCCTGGCGCGTCATCATGTCCGAGCTGGAAGCGC
GCTGGCAGGCCGTGGCGCATCAGGTGCCATCGGATGTCGATCAGACGAGCATCGGCCTACGGCAGTGGGCGAATTCGCTG
GCGGCCGAGGCGCGCGACGTGAACAGCCTGCCATTCTGGGTTGCTCAGCTTGACGGTGACGATCCCGACATCGGTTCGCG
CAGGATCGCTCCCGAGACGGATCGGGACAGTGAGGTGGCCATAACCGCTGAAGCCGCCCCGGTCGGAGTCAGTGAGCTGC
TGCTGAATTCCGGTGTGCCGATGGAACGGCTCCTTGCGGCGGCGGTGGCGCGCACCATAGCCCAGTGGCGCCGTGGGCGG
GGCCAGGCCACGGTAGAGCCTCTACTGGCGATTCAGATTCCCGGCCGTGGCGAGTCCACCGCGGCAACGGTGGGGCCGCT
GAGCACGGTGTATCCGTTGCGCCTCGGCGGCACCGATCCGCTCGCGGTCGGGCCACGTCCTCTGGTGGAGCGTATCGCCC
AGCAGTATCGGGCGATGCCGGGGCGGAGTATCGACTACGGCTTGCTGCGCTATTTGCGAGGCGACACCAGGGCGGTATTG
CGCAAGTACCGCGATCCGCAGGTATTGCTGACTTATCTGGGACATGACGCGGGATTTGAAGGAGACCTCCTGCAACGGGA
CGAATGGCTCTCGGTATTGGGTTCTCCTGTTCCGGAGCCCGATTCGTCGGTACGTCATGAGCTGTCCATCGCGGCGCTGA
TCATGGAGACGACCGAGGGGCCGGTCGTAGGGACCTTGTGGCGCGCGATTCCGGAGGTACTCAGTCGCGCGGAGGTCACC
CAACTGCAAGCGATATGGCACGAACAGCTGGGAATTCTGGCAAAGGAGCAATGGTGA

Upstream 100 bases:

>100_bases
ATCGGGGCTCCTCGTGGGTGACCCCTCGCAGTCTAGATAGGGTAGCCTCCTCGTAGTTAGGGCAGCCTGTACTAATAGTG
AAAACGCGAGGTGAGATCGA

Downstream 100 bases:

>100_bases
CGTCGACATTGGCAGTGATAGGTGCGGGCGCCAAGGCGGTCGCGGTGGCCGCGAAGGCAGCCGTACTGCGCGAATGCGGT
GTCGACGTGCCCGACGTGGT

Product: peptide synthetase MbtE

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1458; Mature: 1458

Protein sequence:

>1458_residues
MRTVSDGDVEVGVTSGEAPVGLGIAAMPLSAGQHRIWFAHGVTPVLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRT
TVHAGADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIRTGSAEYVMLVVAHRI
GWDDESWQVFLADLTAAYVHGGISEPLSSAPKQGGPGDAAVDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSV
SVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGNVLPLRMRPRADESFKDLLAR
VRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELFCPPGIRCEKAAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDE
RMATQLLRHFANVLEAVLADPDRMVGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYS
YRETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPDRIAHILADAQPRLVIREPVT
GLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGVTVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGE
IFGILSCGGRLVIPRPGGLTDVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHAT
FDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGEIYIAGTHLARGYHRAPALTA
QRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVKIRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVA
YLTPIGGHVVDIDRIRSRISAALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQV
LGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMGSTADSVDSAPEGEPIPLLPG
GHSLYEYGNPRRLAVTCVFRLHDGVNRAALEQLLGAVVGEHEALHSRLDRESMTLVPRARPALRFVEIVAADPSVAAAAE
IARAVDRLDPEQGWMLSAVWLHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQAVAHQVPSDVDQTSIGLRQWANSL
AAEARDVNSLPFWVAQLDGDDPDIGSRRIAPETDRDSEVAITAEAAPVGVSELLLNSGVPMERLLAAAVARTIAQWRRGR
GQATVEPLLAIQIPGRGESTAATVGPLSTVYPLRLGGTDPLAVGPRPLVERIAQQYRAMPGRSIDYGLLRYLRGDTRAVL
RKYRDPQVLLTYLGHDAGFEGDLLQRDEWLSVLGSPVPEPDSSVRHELSIAALIMETTEGPVVGTLWRAIPEVLSRAEVT
QLQAIWHEQLGILAKEQW

Sequences:

>Translated_1458_residues
MRTVSDGDVEVGVTSGEAPVGLGIAAMPLSAGQHRIWFAHGVTPVLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRT
TVHAGADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIRTGSAEYVMLVVAHRI
GWDDESWQVFLADLTAAYVHGGISEPLSSAPKQGGPGDAAVDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSV
SVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGNVLPLRMRPRADESFKDLLAR
VRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELFCPPGIRCEKAAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDE
RMATQLLRHFANVLEAVLADPDRMVGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYS
YRETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPDRIAHILADAQPRLVIREPVT
GLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGVTVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGE
IFGILSCGGRLVIPRPGGLTDVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHAT
FDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGEIYIAGTHLARGYHRAPALTA
QRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVKIRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVA
YLTPIGGHVVDIDRIRSRISAALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQV
LGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMGSTADSVDSAPEGEPIPLLPG
GHSLYEYGNPRRLAVTCVFRLHDGVNRAALEQLLGAVVGEHEALHSRLDRESMTLVPRARPALRFVEIVAADPSVAAAAE
IARAVDRLDPEQGWMLSAVWLHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQAVAHQVPSDVDQTSIGLRQWANSL
AAEARDVNSLPFWVAQLDGDDPDIGSRRIAPETDRDSEVAITAEAAPVGVSELLLNSGVPMERLLAAAVARTIAQWRRGR
GQATVEPLLAIQIPGRGESTAATVGPLSTVYPLRLGGTDPLAVGPRPLVERIAQQYRAMPGRSIDYGLLRYLRGDTRAVL
RKYRDPQVLLTYLGHDAGFEGDLLQRDEWLSVLGSPVPEPDSSVRHELSIAALIMETTEGPVVGTLWRAIPEVLSRAEVT
QLQAIWHEQLGILAKEQW
>Mature_1458_residues
MRTVSDGDVEVGVTSGEAPVGLGIAAMPLSAGQHRIWFAHGVTPVLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRT
TVHAGADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIRTGSAEYVMLVVAHRI
GWDDESWQVFLADLTAAYVHGGISEPLSSAPKQGGPGDAAVDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSV
SVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGNVLPLRMRPRADESFKDLLAR
VRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELFCPPGIRCEKAAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDE
RMATQLLRHFANVLEAVLADPDRMVGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYS
YRETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPDRIAHILADAQPRLVIREPVT
GLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGVTVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGE
IFGILSCGGRLVIPRPGGLTDVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHAT
FDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGEIYIAGTHLARGYHRAPALTA
QRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVKIRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVA
YLTPIGGHVVDIDRIRSRISAALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQV
LGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMGSTADSVDSAPEGEPIPLLPG
GHSLYEYGNPRRLAVTCVFRLHDGVNRAALEQLLGAVVGEHEALHSRLDRESMTLVPRARPALRFVEIVAADPSVAAAAE
IARAVDRLDPEQGWMLSAVWLHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQAVAHQVPSDVDQTSIGLRQWANSL
AAEARDVNSLPFWVAQLDGDDPDIGSRRIAPETDRDSEVAITAEAAPVGVSELLLNSGVPMERLLAAAVARTIAQWRRGR
GQATVEPLLAIQIPGRGESTAATVGPLSTVYPLRLGGTDPLAVGPRPLVERIAQQYRAMPGRSIDYGLLRYLRGDTRAVL
RKYRDPQVLLTYLGHDAGFEGDLLQRDEWLSVLGSPVPEPDSSVRHELSIAALIMETTEGPVVGTLWRAIPEVLSRAEVT
QLQAIWHEQLGILAKEQW

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=559, Percent_Identity=23.7924865831843, Blast_Score=110, Evalue=1e-23,
Organism=Homo sapiens, GI122937307, Length=523, Percent_Identity=21.0325047801147, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1786801, Length=797, Percent_Identity=34.3789209535759, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=24.3396226415094, Blast_Score=111, Evalue=4e-25,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=23.9299610894942, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI221142682, Length=498, Percent_Identity=23.6947791164659, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788107, Length=377, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=555, Percent_Identity=27.7477477477477, Blast_Score=139, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17550940, Length=506, Percent_Identity=23.9130434782609, Blast_Score=111, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=377, Percent_Identity=26.2599469496021, Blast_Score=88, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=615, Percent_Identity=20.9756097560976, Blast_Score=78, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=550, Percent_Identity=21.0909090909091, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994703, Length=550, Percent_Identity=21.0909090909091, Blast_Score=77, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=959, Percent_Identity=25.2346193952033, Blast_Score=254, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=22.7272727272727, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648676, Length=652, Percent_Identity=30.6748466257669, Blast_Score=233, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24581924, Length=575, Percent_Identity=21.2173913043478, Blast_Score=72, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 157910; Mature: 157910

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVSDGDVEVGVTSGEAPVGLGIAAMPLSAGQHRIWFAHGVTPVLMNLCRSYRLHGELD
CCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC
VDKLRAAVAAVVLRHAALRTTVHAGADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHH
VLAQREYGTAFDLATEAPLRVTVIRTGSAEYVMLVVAHRIGWDDESWQVFLADLTAAYVH
HHHHHCCCCEEECCCCCCEEEEEEECCCCCEEEEEEHHHCCCCCCCCEEEHHHHHHHHHC
GGISEPLSSAPKQGGPGDAAVDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSV
CCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHH
SVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCC
VLPLRMRPRADESFKDLLARVRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELFCPPGI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCC
RCEKAAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDERMATQLLRHFANVLEAVLAD
CCHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDRMVGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYS
CHHHEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
YRETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPD
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHCCEEEEECCCCCCHH
RIAHILADAQPRLVIREPVTGLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGV
HHHHHHHCCCCCEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
TVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGEIFGILSCGGRLVIPRPGGLT
EEECCHHHHHHHHHHHHHEECCCCCEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCCCH
DVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHAT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHH
FDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGE
HHHHHHHHCCCHHHHHCCCCEEEECCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCE
IYIAGTHLARGYHRAPALTAQRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVK
EEEEEHHHHCCHHCCCHHHHHHHHCCCCCCHHHHHHCCCCHHCCCCCCEEEECCCCCEEE
IRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVAYLTPIGGHVVDIDRIRSRIS
EEEEEEEHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
AALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQV
HHCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHH
LGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMG
HHHEEECCCCCHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHCC
STADSVDSAPEGEPIPLLPGGHSLYEYGNPRRLAVTCVFRLHDGVNRAALEQLLGAVVGE
CCCHHCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHCC
HEALHSRLDRESMTLVPRARPALRFVEIVAADPSVAAAAEIARAVDRLDPEQGWMLSAVW
HHHHHHHHCCCCEEECCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
LHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQAVAHQVPSDVDQTSIGLRQWANSL
ECCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AAEARDVNSLPFWVAQLDGDDPDIGSRRIAPETDRDSEVAITAEAAPVGVSELLLNSGVP
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCC
MERLLAAAVARTIAQWRRGRGQATVEPLLAIQIPGRGESTAATVGPLSTVYPLRLGGTDP
HHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEECCCCCCCCEEEECCCCC
LAVGPRPLVERIAQQYRAMPGRSIDYGLLRYLRGDTRAVLRKYRDPQVLLTYLGHDAGFE
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHCCCHHHHHEECCCCCCCC
GDLLQRDEWLSVLGSPVPEPDSSVRHELSIAALIMETTEGPVVGTLWRAIPEVLSRAEVT
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
QLQAIWHEQLGILAKEQW
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRTVSDGDVEVGVTSGEAPVGLGIAAMPLSAGQHRIWFAHGVTPVLMNLCRSYRLHGELD
CCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC
VDKLRAAVAAVVLRHAALRTTVHAGADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHH
VLAQREYGTAFDLATEAPLRVTVIRTGSAEYVMLVVAHRIGWDDESWQVFLADLTAAYVH
HHHHHCCCCEEECCCCCCEEEEEEECCCCCEEEEEEHHHCCCCCCCCEEEHHHHHHHHHC
GGISEPLSSAPKQGGPGDAAVDYWREELSNPAEPLELPGPNGAVVPTDWKAARCTAHLSV
CCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHH
SVMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPALDPHARGRIGHFGN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCC
VLPLRMRPRADESFKDLLARVRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELFCPPGI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCC
RCEKAAFESHVAYVPLGLTVEVKSGGADVVAEYLVTVLDERMATQLLRHFANVLEAVLAD
CCHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDRMVGAVDLMDDREAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYS
CHHHEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
YRETNDLANRLAHWIIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPD
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHCCEEEEECCCCCCHH
RIAHILADAQPRLVIREPVTGLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGV
HHHHHHHCCCCCEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
TVTHRPLTEYFNWFRAEYRVGGSDRVLQVGSPSFDVSIGEIFGILSCGGRLVIPRPGGLT
EEECCHHHHHHHHHHHHHEECCCCCEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCCCH
DVAYLTALLNSEAVTSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHAT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHH
FDASLHNFYGPTEAIINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGE
HHHHHHHHCCCHHHHHCCCCEEEECCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCE
IYIAGTHLARGYHRAPALTAQRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVK
EEEEEHHHHCCHHCCCHHHHHHHHCCCCCCHHHHHHCCCCHHCCCCCCEEEECCCCCEEE
IRGFRVELGEISSAIEVDPSVSQALVVVDELPHLGKRLVAYLTPIGGHVVDIDRIRSRIS
EEEEEEEHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
AALPDYMIPAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQV
HHCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHH
LGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMG
HHHEEECCCCCHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHHHHHHCC
STADSVDSAPEGEPIPLLPGGHSLYEYGNPRRLAVTCVFRLHDGVNRAALEQLLGAVVGE
CCCHHCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHCC
HEALHSRLDRESMTLVPRARPALRFVEIVAADPSVAAAAEIARAVDRLDPEQGWMLSAVW
HHHHHHHHCCCCEEECCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
LHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQAVAHQVPSDVDQTSIGLRQWANSL
ECCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AAEARDVNSLPFWVAQLDGDDPDIGSRRIAPETDRDSEVAITAEAAPVGVSELLLNSGVP
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCC
MERLLAAAVARTIAQWRRGRGQATVEPLLAIQIPGRGESTAATVGPLSTVYPLRLGGTDP
HHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEECCCCCCCCEEEECCCCC
LAVGPRPLVERIAQQYRAMPGRSIDYGLLRYLRGDTRAVLRKYRDPQVLLTYLGHDAGFE
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHCCCHHHHHEECCCCCCCC
GDLLQRDEWLSVLGSPVPEPDSSVRHELSIAALIMETTEGPVVGTLWRAIPEVLSRAEVT
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
QLQAIWHEQLGILAKEQW
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA