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The map label for this gene is pepE [H]

Identifier: 169629278

GI number: 169629278

Start: 2207417

End: 2208541

Strand: Direct

Name: pepE [H]

Synonym: MAB_2192

Alternate gene names: 169629278

Gene position: 2207417-2208541 (Clockwise)

Preceding gene: 169629276

Following gene: 169629280

Centisome position: 43.56

GC content: 66.04

Gene sequence:

>1125_bases
ATGGCACCCCAGCGTTTCGAATCCGACGTCTACGCCGACCGACTGCGACGCGCGGCCCAGGAGGCCGAGAAGGTGGGAGT
GACGGGTCTGGTGGTCACCCCCGGATACGACCTGCGGTACCTCACGGGATCGCGCGCGCAGACGTTCGAGCGGCTCACCG
CCCTGGTGGTGCCGGCGACGGGGCAGCCCACTGTGGTCGCTCCTCGGATGGAGCTTGCGGCGCTGCGGGATTCAGCTATC
GGCGACCTGAACATTCCCATCAGCGATTGGGTCGACGGGGAGAATCCCTACGAGCTGGTGCGCGCGGCACTGGGGACCGC
CGGAACTGTGGCGGTGACCGAGTCGATGCCCGCACTGCACCTGTTGCCGCTGGCGCAACTGGTCGGAACGGTGCCGGTCT
TGGCAACCGGCGTGCTACGCCGGTTGCGCATGGTCAAAGACGCCTCCGAGATCGACGCGCTGCGTAAGGCCGGCGCCGCC
ATCGACCGGGTGCACGCCCTGGTACCCGAATTACTGATTCCGGGGCGCACGGAGGCGCAGGTGGCCGCGGATATCGCTGA
AGCGATTGTGGCCGAGGGGCATTCGGAGGTGGCTTTCATCATCGTCGGTTCCGGCCCACACGGGGCCGACCCGCACCATG
AGTGCTCGGATCGTGAACTGCGGACCGGGGACATTGTGGTGGTGGACATCGGCGGTAGCTACGAGCCGGGTTATAACTCC
GACAGCACCCGCACCTACAGTATTGGTGAGCCTGACCCCGATGTTGCTCAACGGATTTCGGTGCTTGAGCGGGCGCAGCA
GGCGGCGGTACATGCGGCCCGTCCCGGTGTGACGGCGGAGTCGGTGGATGCCGCCGCGCGCCGGGTTCTGACCGAAGCGG
GGATGGGTGAGGCCTTTGTACATCGCACCGGACACGGCATCGGGCTGTCGGTACATGAGGAGCCGTACATCGTCGAGGGC
AACGAACTGGTACTCGAACCCGGTATGGCCTTCAGTATTGAGCCGGGCGTGTACTTCCCGGGCCAGTGGGGTGCGCGGAT
CGAGGACATCGTCGTCATCACCGAAAACGGTTGCGAATCGGTGAATTCGCGGCCCCACGGCCTGACGGTGGTGCCTACTC
GCTAG

Upstream 100 bases:

>100_bases
ACAGGCTGGCGCCGTCGAGCAGCAAGACGGGTCTGGCGGGAACGGTTCGGGCTGGGTCTTCTGACACAGCACTCAACCTA
TGCCAGATAGCCTGGACCGT

Downstream 100 bases:

>100_bases
GACTGTCGGCCCGGTTCAGCAGATCCGAAGAACCCAGCACCCGCTCGATCTTGACCTCGATGACCACCCGCTTCGGGTTG
ACACGCGGGGTGCGGTAGCG

Product: dipeptidase PepE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MAPQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQTFERLTALVVPATGQPTVVAPRMELAALRDSAI
GDLNIPISDWVDGENPYELVRAALGTAGTVAVTESMPALHLLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAA
IDRVHALVPELLIPGRTEAQVAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELRTGDIVVVDIGGSYEPGYNS
DSTRTYSIGEPDPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFVHRTGHGIGLSVHEEPYIVEG
NELVLEPGMAFSIEPGVYFPGQWGARIEDIVVITENGCESVNSRPHGLTVVPTR

Sequences:

>Translated_374_residues
MAPQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQTFERLTALVVPATGQPTVVAPRMELAALRDSAI
GDLNIPISDWVDGENPYELVRAALGTAGTVAVTESMPALHLLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAA
IDRVHALVPELLIPGRTEAQVAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELRTGDIVVVDIGGSYEPGYNS
DSTRTYSIGEPDPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFVHRTGHGIGLSVHEEPYIVEG
NELVLEPGMAFSIEPGVYFPGQWGARIEDIVVITENGCESVNSRPHGLTVVPTR
>Mature_373_residues
APQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQTFERLTALVVPATGQPTVVAPRMELAALRDSAIG
DLNIPISDWVDGENPYELVRAALGTAGTVAVTESMPALHLLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAAI
DRVHALVPELLIPGRTEAQVAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELRTGDIVVVDIGGSYEPGYNSD
STRTYSIGEPDPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFVHRTGHGIGLSVHEEPYIVEGN
ELVLEPGMAFSIEPGVYFPGQWGARIEDIVVITENGCESVNSRPHGLTVVPTR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI93141226, Length=308, Percent_Identity=31.1688311688312, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI264681563, Length=270, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI11559925, Length=252, Percent_Identity=25.7936507936508, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI149589008, Length=289, Percent_Identity=24.5674740484429, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI260593665, Length=288, Percent_Identity=24.6527777777778, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI40385867, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788728, Length=230, Percent_Identity=38.695652173913, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789275, Length=255, Percent_Identity=29.0196078431373, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39740; Mature: 39609

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQTFERLTALVVPAT
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHHHHHHHEEEECCC
GQPTVVAPRMELAALRDSAIGDLNIPISDWVDGENPYELVRAALGTAGTVAVTESMPALH
CCCEEEECCHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCHHH
LLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAAIDRVHALVPELLIPGRTEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELRTGDIVVVDIGGSYEPGYNS
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
DSTRTYSIGEPDPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFV
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
HRTGHGIGLSVHEEPYIVEGNELVLEPGMAFSIEPGVYFPGQWGARIEDIVVITENGCES
HCCCCCEEEEECCCCEEECCCEEEECCCCEEEECCCEECCCCCCCCEEEEEEEECCCCHH
VNSRPHGLTVVPTR
CCCCCCCEEEECCC
>Mature Secondary Structure 
APQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQTFERLTALVVPAT
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHHHHHHHEEEECCC
GQPTVVAPRMELAALRDSAIGDLNIPISDWVDGENPYELVRAALGTAGTVAVTESMPALH
CCCEEEECCHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCHHH
LLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAAIDRVHALVPELLIPGRTEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELRTGDIVVVDIGGSYEPGYNS
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
DSTRTYSIGEPDPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFV
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
HRTGHGIGLSVHEEPYIVEGNELVLEPGMAFSIEPGVYFPGQWGARIEDIVVITENGCES
HCCCCCEEEEECCCCEEECCCEEEECCCCEEEECCCEECCCCCCCCEEEEEEEECCCCHH
VNSRPHGLTVVPTR
CCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]