Click here to switch to the map view.

The map label for this gene is ilvB [H]

Identifier: 169629251

GI number: 169629251

Start: 2179508

End: 2181202

Strand: Direct

Name: ilvB [H]

Synonym: MAB_2165

Alternate gene names: 169629251

Gene position: 2179508-2181202 (Clockwise)

Preceding gene: 169629250

Following gene: 169629252

Centisome position: 43.01

GC content: 62.36

Gene sequence:

>1695_bases
GTGGTTGACTGGCTTGTCTCGGAGCTGCGTCGTCACGCCGTCGACTTCGTCTTTGGCGTAGACGGCGCCAACATCGAGGA
TCTTTACGACGCCGTGCACTACGCGCCGGGCATGCAAGCCGTAGTTGCCAAACACGAGTTCTCGGCTGGGACGATGGCTG
ACGGATATGCGCGTGTCACGTCGCGGATGAGCGTGGTGGCCACCACATCCGGTGGTGGGGCAGTCAATCTTGTTCCAGCG
CTGGCGGAATCATATGCGAGTGCGGTTCCCGTGCTGGCGATCGTAGGCCAGCCGCCTCGGTCGTTGGAGGGCAATGGCGC
GTTCCAGGACGGCAGCGGGCGTGCCGGCAGCATGGATCTGCGGGCAGTATTTCGGCCCGTCTCCGGCTATTGCGCCAGGG
TGGAGCATTCCGGAGAAATCGCGGAGGCGCTTTCCGGCGCTCTGGCCGCCATTCGTGATGGCCTACCTGCGGTTCTGTTG
ATCCCCAAAGATGTTCAGCAGGCACGGCTGGCGGTGGAACCGCAGCTGCGGGAGCCGCTTCCGCGTTTGGGGACGGTACC
GGTACAACTAGCCGACTTCGCCGGGCATCTGATCAAGACACCCGGCAGAATCCTGGTGGTAGCCGGCCCCGAGGTGGCCC
GGCAGGACGCCCGCGAGGAGCTGGCAGACCTTGTCGATCGCCTTGATGCCCTTGTGGCTGTCTCGCCTGACGCCAAAGAT
ACTGTGAAAAGCGAGAATCCACGACTGCTCGGCGTCATTGGTGTTATGGGCCACCCCGCCGTGGAGCAGGTCATGCGTCA
TGGTGTTACATGCGTCTGCGTCGGCACCACCATGCCTGTGATGACGCGAGGGGCAGTTGACTTCTCGAAAATCCCGGTGC
TGTCCATCGGCTCCGCGGCGCCACATGTCGCCTCGCGACATTTGCAGACGCACGATTTGGTATCGACGTTGGCGGGCCTC
GCGGCGGCTCTCCCGGCGCGACCGGAGACTTCCGATAGTGAAACACTCTACGCACCAGCTCATCTCGAGCCTCCGGCGCA
CGATGGTGACGGTGTGCGATACCACGATGTCATGCACGTGCTGGACCGGGCTATTCCTGCCGGGGCCGATATCTTCGTGG
ACGCGGGCAACACCGGTGCCGCCGCCGTGCATTACCTGGGAGCGCGACAGCACGGTCGTTACGTCGTCGCGCTCGGCATG
GGTGGCATGGGATATGCCTTCGGTGCAGGTATTGGCTGTGCGTTCGCGCGGCCGGGCCGTACCGTTGTAATTGCAGGTGA
TGGCGCGTTCTTCATGCACGGCATGGAGATTCATACGGCCATCGAACACCGACTGCCGGTGACATTCGTCATCGTCAATA
ACAACGCGCATGCCATGTGCGTCACTCGCGAACAGCTCTACTACGGGGGGAGCTACAGCTTCAATCGGTTCGCGCCTTCA
CACATTGCCTCCGGACTGGGCGCGATGTTCCCCGGCCTGATGTGTCATTCGGCCGATACGGTGGCCGATTTGGAGGCCGC
CATGCAGCAGGTGATGACGCACCACGGCCCGTCCGTGGTCGAGGTCATCTGTTCCACCGACGAGATACCCCCGTTTGCTC
CATTCTTGTCACCCGAAATCGCTAAGGAGAGAACGCATGACCGACACGATTGCAAAAACGGCCAATCCTGGCCTCAAAGC
CTTGCCCGCGCTTAG

Upstream 100 bases:

>100_bases
ACCCGTCACGTGTGACAGTCGTGTACTAGTCATGACCACCCCGATGTGCGCCCGGAGTCGTGCGGTCGGCGACCTTCCGC
CCCGGAGCGGGAACGTGCGA

Downstream 100 bases:

>100_bases
TGATATCGCTGCCGAAGCCGGCACCGAAGACGCGCTGCCCGGAGTGCACCGCATCGAGACCTCGCCACGCGAAAAGGCGA
CACCGATCATCATGGACATG

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MVDWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTMADGYARVTSRMSVVATTSGGGAVNLVPA
LAESYASAVPVLAIVGQPPRSLEGNGAFQDGSGRAGSMDLRAVFRPVSGYCARVEHSGEIAEALSGALAAIRDGLPAVLL
IPKDVQQARLAVEPQLREPLPRLGTVPVQLADFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKD
TVKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVGTTMPVMTRGAVDFSKIPVLSIGSAAPHVASRHLQTHDLVSTLAGL
AAALPARPETSDSETLYAPAHLEPPAHDGDGVRYHDVMHVLDRAIPAGADIFVDAGNTGAAAVHYLGARQHGRYVVALGM
GGMGYAFGAGIGCAFARPGRTVVIAGDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGGSYSFNRFAPS
HIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHGPSVVEVICSTDEIPPFAPFLSPEIAKERTHDRHDCKNGQSWPQS
LARA

Sequences:

>Translated_564_residues
MVDWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTMADGYARVTSRMSVVATTSGGGAVNLVPA
LAESYASAVPVLAIVGQPPRSLEGNGAFQDGSGRAGSMDLRAVFRPVSGYCARVEHSGEIAEALSGALAAIRDGLPAVLL
IPKDVQQARLAVEPQLREPLPRLGTVPVQLADFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKD
TVKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVGTTMPVMTRGAVDFSKIPVLSIGSAAPHVASRHLQTHDLVSTLAGL
AAALPARPETSDSETLYAPAHLEPPAHDGDGVRYHDVMHVLDRAIPAGADIFVDAGNTGAAAVHYLGARQHGRYVVALGM
GGMGYAFGAGIGCAFARPGRTVVIAGDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGGSYSFNRFAPS
HIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHGPSVVEVICSTDEIPPFAPFLSPEIAKERTHDRHDCKNGQSWPQS
LARA
>Mature_564_residues
MVDWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTMADGYARVTSRMSVVATTSGGGAVNLVPA
LAESYASAVPVLAIVGQPPRSLEGNGAFQDGSGRAGSMDLRAVFRPVSGYCARVEHSGEIAEALSGALAAIRDGLPAVLL
IPKDVQQARLAVEPQLREPLPRLGTVPVQLADFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKD
TVKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVGTTMPVMTRGAVDFSKIPVLSIGSAAPHVASRHLQTHDLVSTLAGL
AAALPARPETSDSETLYAPAHLEPPAHDGDGVRYHDVMHVLDRAIPAGADIFVDAGNTGAAAVHYLGARQHGRYVVALGM
GGMGYAFGAGIGCAFARPGRTVVIAGDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGGSYSFNRFAPS
HIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHGPSVVEVICSTDEIPPFAPFLSPEIAKERTHDRHDCKNGQSWPQS
LARA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=180, Percent_Identity=30, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790104, Length=553, Percent_Identity=25.1356238698011, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI87081685, Length=548, Percent_Identity=25.5474452554745, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1787096, Length=559, Percent_Identity=24.1502683363148, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786717, Length=567, Percent_Identity=24.5149911816578, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17542570, Length=566, Percent_Identity=24.0282685512367, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323755, Length=608, Percent_Identity=25.1644736842105, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323073, Length=506, Percent_Identity=23.7154150197628, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=495, Percent_Identity=22.8282828282828, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=497, Percent_Identity=24.1448692152917, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59477; Mature: 59477

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTMADGYARVT
CHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHH
SRMSVVATTSGGGAVNLVPALAESYASAVPVLAIVGQPPRSLEGNGAFQDGSGRAGSMDL
CCEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
RAVFRPVSGYCARVEHSGEIAEALSGALAAIRDGLPAVLLIPKDVQQARLAVEPQLREPL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHCCC
PRLGTVPVQLADFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKD
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
TVKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVGTTMPVMTRGAVDFSKIPVLSIGSAA
HHCCCCCEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCHHCCCCCCHHCCCEEEECCCC
PHVASRHLQTHDLVSTLAGLAAALPARPETSDSETLYAPAHLEPPAHDGDGVRYHDVMHV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHH
LDRAIPAGADIFVDAGNTGAAAVHYLGARQHGRYVVALGMGGMGYAFGAGIGCAFARPGR
HHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCEEECCCCC
TVVIAGDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGGSYSFNRFAPS
EEEEECCCEEEEECHHHHHHHHCCCCEEEEEECCCCEEEEEEHHHHEECCCCCCCCCCHH
HIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHGPSVVEVICSTDEIPPFAPFLSPEI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHH
AKERTHDRHDCKNGQSWPQSLARA
HHHHCCCHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MVDWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTMADGYARVT
CHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHH
SRMSVVATTSGGGAVNLVPALAESYASAVPVLAIVGQPPRSLEGNGAFQDGSGRAGSMDL
CCEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
RAVFRPVSGYCARVEHSGEIAEALSGALAAIRDGLPAVLLIPKDVQQARLAVEPQLREPL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHCCC
PRLGTVPVQLADFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKD
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
TVKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVGTTMPVMTRGAVDFSKIPVLSIGSAA
HHCCCCCEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCHHCCCCCCHHCCCEEEECCCC
PHVASRHLQTHDLVSTLAGLAAALPARPETSDSETLYAPAHLEPPAHDGDGVRYHDVMHV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHH
LDRAIPAGADIFVDAGNTGAAAVHYLGARQHGRYVVALGMGGMGYAFGAGIGCAFARPGR
HHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCEEECCCCC
TVVIAGDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGGSYSFNRFAPS
EEEEECCCEEEEECHHHHHHHHCCCCEEEEEECCCCEEEEEEHHHHEECCCCCCCCCCHH
HIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHGPSVVEVICSTDEIPPFAPFLSPEI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHH
AKERTHDRHDCKNGQSWPQSLARA
HHHHCCCHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]