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The map label for this gene is nuoD

Identifier: 169629223

GI number: 169629223

Start: 2147792

End: 2149090

Strand: Direct

Name: nuoD

Synonym: MAB_2137

Alternate gene names: 169629223

Gene position: 2147792-2149090 (Clockwise)

Preceding gene: 169629222

Following gene: 169629224

Centisome position: 42.39

GC content: 60.74

Gene sequence:

>1299_bases
ATGACAGCACAGCCCGAAATCCATCTCATGGCGGGTGGCCAGGACTGGGATGAGATTGTCACCGCCGCAGGGCAAGCCAC
CGACGAACGGATCGTCGTCAACATGGGTCCGCAGCATCCATCCACGCACGGTGTGCTGCGTTTGATCCTGGAGATCGAGG
GCGAGACGGTGACCGATGTGCGCTGCGGTATCGGCTATCTGCATACGGGCATCGAAAAAAACCTGGAATACCGCACCTGG
ACACAGGGCGTCACCTTTGTCACCCGGATGGACTACCTGTCCCCCTTCTTCAACGAGACTGCCTATTGCTTGGGCGTAGA
GCAGCTATTGGGTATTGCGGACGAAATTCCCGAACGTGCCAATGTGATTCGCGTGCTGATGATGGAGTTGAACCGCATCT
CCTCGCACCTGGTCGCGCTGGCCACCGGGGGCATGGAGCTCGGCGCGATGACTGCCATGTTCCTCGGTTTCCGCGAACGC
GAAATGATCCTGAAGGTCTTTGAGGCGATCACCGGCCTGCGTATGAATCACGCCTATGTGCGGCCCGGTGGCCTCGCGCA
AGATTTGCCCGACGGCGCCGAGCAAGAGGTCCGGGACCTGCTCGAGATCTTGCCCGGCAGGTTGCGCGACATGGAAAACC
TGTTGAACGAGAACTACATCTGGAAGGCCCGCACCCAGGGCGTTGGGTACCTGGACCTCACCGGGTGTATGGCCTTGGGT
ATAACCGGTCCGGTGCTGCGTGCCACCGGGTTGGCGCACGACCTACGGCGCGCCCAGCCGTATTGCGGCTACGAGAACTA
CGATTTCGACGTCGTTACCCACCAGGATTGCGATTCCTATGGCCGGTATCTCATCCGGGTCAAAGAGATGCACGAATCCA
TCAAGATCGCTCAGCAATGTGTGGATAGGCTGCGCCCCGGGCCGGTCATGGTGGATGACAAGAAGATCGCCTGGCCAGCC
GATCTGGCGTCTGGTCCCGACGGCCTGGGTAATTCACCCAAACACATCGCCAAGATCATGGGCACCTCGATGGAGGGACT
GATACACCATTTCAAACTGGTGACGGAGGGGGTGCGGGTGCCCGCCGGACAGGTATACGTGGCGATCGAATCGCCGCGTG
GAGAGCTGGGCGTGCACATGGTCAGTGACGGCGGAACCCGGCCCTACCGGGTTCATTTCAGGGACCCCTCGTTCACGAAC
CTGCAGTCCGTTGCCGCCATGTGTGAGGGCGCGATGGTGGCCGACTTGATCGCCGCGGTGGCGAGCATTGATCCGGTGAT
GGGGGGAGTGGACAGGTGA

Upstream 100 bases:

>100_bases
ACGGGCACCCGCAGCGCAAGGACTACCCGCTGGGTGGTGTGCCGGTCGAGTATCACGGAGCAACCATTGCACCGCCCGAT
CAGCGGAGGTCTTACAACTA

Downstream 100 bases:

>100_bases
CCGAGGTATTTGTCGAACTGGGTAGCCGTCCGTCAGAGGACGAAGGTCGATTCGCTGGGCGTAAACACTATCCGGCGGAG
GTGGTTTCACGGCTGGCCAT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTAQPEIHLMAGGQDWDEIVTAAGQATDERIVVNMGPQHPSTHGVLRLILEIEGETVTDVRCGIGYLHTGIEKNLEYRTW
TQGVTFVTRMDYLSPFFNETAYCLGVEQLLGIADEIPERANVIRVLMMELNRISSHLVALATGGMELGAMTAMFLGFRER
EMILKVFEAITGLRMNHAYVRPGGLAQDLPDGAEQEVRDLLEILPGRLRDMENLLNENYIWKARTQGVGYLDLTGCMALG
ITGPVLRATGLAHDLRRAQPYCGYENYDFDVVTHQDCDSYGRYLIRVKEMHESIKIAQQCVDRLRPGPVMVDDKKIAWPA
DLASGPDGLGNSPKHIAKIMGTSMEGLIHHFKLVTEGVRVPAGQVYVAIESPRGELGVHMVSDGGTRPYRVHFRDPSFTN
LQSVAAMCEGAMVADLIAAVASIDPVMGGVDR

Sequences:

>Translated_432_residues
MTAQPEIHLMAGGQDWDEIVTAAGQATDERIVVNMGPQHPSTHGVLRLILEIEGETVTDVRCGIGYLHTGIEKNLEYRTW
TQGVTFVTRMDYLSPFFNETAYCLGVEQLLGIADEIPERANVIRVLMMELNRISSHLVALATGGMELGAMTAMFLGFRER
EMILKVFEAITGLRMNHAYVRPGGLAQDLPDGAEQEVRDLLEILPGRLRDMENLLNENYIWKARTQGVGYLDLTGCMALG
ITGPVLRATGLAHDLRRAQPYCGYENYDFDVVTHQDCDSYGRYLIRVKEMHESIKIAQQCVDRLRPGPVMVDDKKIAWPA
DLASGPDGLGNSPKHIAKIMGTSMEGLIHHFKLVTEGVRVPAGQVYVAIESPRGELGVHMVSDGGTRPYRVHFRDPSFTN
LQSVAAMCEGAMVADLIAAVASIDPVMGGVDR
>Mature_431_residues
TAQPEIHLMAGGQDWDEIVTAAGQATDERIVVNMGPQHPSTHGVLRLILEIEGETVTDVRCGIGYLHTGIEKNLEYRTWT
QGVTFVTRMDYLSPFFNETAYCLGVEQLLGIADEIPERANVIRVLMMELNRISSHLVALATGGMELGAMTAMFLGFRERE
MILKVFEAITGLRMNHAYVRPGGLAQDLPDGAEQEVRDLLEILPGRLRDMENLLNENYIWKARTQGVGYLDLTGCMALGI
TGPVLRATGLAHDLRRAQPYCGYENYDFDVVTHQDCDSYGRYLIRVKEMHESIKIAQQCVDRLRPGPVMVDDKKIAWPAD
LASGPDGLGNSPKHIAKIMGTSMEGLIHHFKLVTEGVRVPAGQVYVAIESPRGELGVHMVSDGGTRPYRVHFRDPSFTNL
QSVAAMCEGAMVADLIAAVASIDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=43.8118811881188, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=43.4010152284264, Blast_Score=326, Evalue=3e-89,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=39.0243902439024, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789076, Length=403, Percent_Identity=27.5434243176179, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788832, Length=404, Percent_Identity=25.7425742574257, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17568379, Length=404, Percent_Identity=41.3366336633663, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=40.5940594059406, Blast_Score=344, Evalue=4e-95,
Organism=Drosophila melanogaster, GI221459469, Length=438, Percent_Identity=40.6392694063927, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI24638644, Length=417, Percent_Identity=40.2877697841727, Blast_Score=342, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_MYCA9 (B1MPG7)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702872.1
- ProteinModelPortal:   B1MPG7
- SMR:   B1MPG7
- EnsemblBacteria:   EBMYCT00000008561
- GeneID:   5964650
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2137
- GeneTree:   EBGT00050000016726
- HOGENOM:   HBG459705
- OMA:   LRMNHAF
- ProtClustDB:   PRK06075
- BioCyc:   MABS561007:MAB_2137-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47621; Mature: 47490

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPEIHLMAGGQDWDEIVTAAGQATDERIVVNMGPQHPSTHGVLRLILEIEGETVTDV
CCCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCEEEHH
RCGIGYLHTGIEKNLEYRTWTQGVTFVTRMDYLSPFFNETAYCLGVEQLLGIADEIPERA
HHCHHHHHHHHHCCCCEEEHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCHHHH
NVIRVLMMELNRISSHLVALATGGMELGAMTAMFLGFREREMILKVFEAITGLRMNHAYV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEE
RPGGLAQDLPDGAEQEVRDLLEILPGRLRDMENLLNENYIWKARTQGVGYLDLTGCMALG
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHC
ITGPVLRATGLAHDLRRAQPYCGYENYDFDVVTHQDCDSYGRYLIRVKEMHESIKIAQQC
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VDRLRPGPVMVDDKKIAWPADLASGPDGLGNSPKHIAKIMGTSMEGLIHHFKLVTEGVRV
HHHCCCCCEEECCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
PAGQVYVAIESPRGELGVHMVSDGGTRPYRVHFRDPSFTNLQSVAAMCEGAMVADLIAAV
CCCEEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHH
ASIDPVMGGVDR
HHHHHHHCCCCC
>Mature Secondary Structure 
TAQPEIHLMAGGQDWDEIVTAAGQATDERIVVNMGPQHPSTHGVLRLILEIEGETVTDV
CCCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCEEEHH
RCGIGYLHTGIEKNLEYRTWTQGVTFVTRMDYLSPFFNETAYCLGVEQLLGIADEIPERA
HHCHHHHHHHHHCCCCEEEHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCHHHH
NVIRVLMMELNRISSHLVALATGGMELGAMTAMFLGFREREMILKVFEAITGLRMNHAYV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEE
RPGGLAQDLPDGAEQEVRDLLEILPGRLRDMENLLNENYIWKARTQGVGYLDLTGCMALG
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHC
ITGPVLRATGLAHDLRRAQPYCGYENYDFDVVTHQDCDSYGRYLIRVKEMHESIKIAQQC
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VDRLRPGPVMVDDKKIAWPADLASGPDGLGNSPKHIAKIMGTSMEGLIHHFKLVTEGVRV
HHHCCCCCEEECCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
PAGQVYVAIESPRGELGVHMVSDGGTRPYRVHFRDPSFTNLQSVAAMCEGAMVADLIAAV
CCCEEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHH
ASIDPVMGGVDR
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA