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The map label for this gene is lldD [C]

Identifier: 169629212

GI number: 169629212

Start: 2136658

End: 2137812

Strand: Direct

Name: lldD [C]

Synonym: MAB_2126

Alternate gene names: 169629212

Gene position: 2136658-2137812 (Clockwise)

Preceding gene: 169629210

Following gene: 169629215

Centisome position: 42.17

GC content: 63.81

Gene sequence:

>1155_bases
ATGAACTTCGGCGATTTCCAGCTTCAGTTCTATGCGGCAGGTGCGCTCGGCAAGGTTTCCACCCTTCCGTTCAACTTTGC
CGAGCTGGAGAGCCGTGCCGAGCAGACATTGGGTGAGGGGATCTTCGGCTATGTGCGCGGCGGTGCCGGCGACGAGCACA
CCCAGGACTCGAATGTCACAGCGCTGCGTCGCTATGGACTGGTGCCCCGGATGCTGCGGGATCGCACCGTTCGGGACATG
TCGACCTCATTTCTGGGGCGCACGTTCACGAGCCCGGCCTTCATCTGCCCGGTGGGTGTGTTGGGTGCGGTTCGTGACCG
TGGCGATCTGCTGACGGCCGCCGCCGCGCGCGAGCTCGATATGCCCGCGATGTATTCGACACTTTCCGCGGCCACCCTGG
AAGAGGTCGCCGCCGCGCGCGGTGATTCCTATGGGATCTTCCAGCTGTACCCGTCGTCGGATTCAGAACTGACCGACAAC
TTCATCCGGCGTGCCGAGGCTGCTGGGTACGACGCGCTGGCAGTGACTCTCGACACCGGCACGCTCGGTTGGCGGCCGCG
CGATCTTAAGCATGGGTATCTACCGATGCTGCACGGGCACTGTCTGGCGAATTACACGTCCGATCCCCGGTTTCTGGAGA
TCGCGGGGGTGCGTTCCGCCGGGGAACTGACGCCGATGCATGCCGGGCTGGTGTGGGCCTCGCTGTTCAGTCATCCTGGG
CTCACCTGGGCGGACATCGATCACTACCGGTCGATCACCAAGCTTCCGATCATCCTCAAGGGGATCTGCGACAGCGATGA
TGTCCGGCAAGCGGTGGACCGCGGCGTGGATGCCATCGCCTACTCCAACCACGGTGGGCGCCAAGCGAATGGGGGAGTTC
CCGCGATCGATGGTCTGGCCGCGGCGGTCGAGGCGGCAGGTTCGGTTCCGGTCACATTCGATTCCGGGATACGCGACGGC
ATCGACATCTTGCGGGCCGTGGCGCTCGGCGCCAGCCTGGTGGGGGTTGCGCGTCCCTATGTATACGGACTCGCCCTGGA
CGGTACCAACGGTGTCAAACACGTCATCCAGTCGCTACTCGCCGAGGCCGACCTGACCATGGCGGTGAACTGCTATCTTT
CGCTGAACGAATTGGCGGTGCAGCGGCTTTCCTGA

Upstream 100 bases:

>100_bases
AATTGACATGCCGGTTCGTCTGCGGGCTCGTGCCGTCTGCGGCCAAAGGTGCCCAGTACGCTGAACATCCAGCGAAAGCC
CGAATGGTGAGGAGTGCCCG

Downstream 100 bases:

>100_bases
AGACGCGGTAGCGGGCTAGCCGATGCCCGCCCACCGACCGAGTCGATGGGCGGCGGTCACGATCATCGTGGCCGGCCAGT
TCTAGGCCCGGCGCCGGGCC

Product: putative L-lactate 2-monooxygenase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVTALRRYGLVPRMLRDRTVRDM
STSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELDMPAMYSTLSAATLEEVAAARGDSYGIFQLYPSSDSELTDN
FIRRAEAAGYDALAVTLDTGTLGWRPRDLKHGYLPMLHGHCLANYTSDPRFLEIAGVRSAGELTPMHAGLVWASLFSHPG
LTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAYSNHGGRQANGGVPAIDGLAAAVEAAGSVPVTFDSGIRDG
IDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLLAEADLTMAVNCYLSLNELAVQRLS

Sequences:

>Translated_384_residues
MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVTALRRYGLVPRMLRDRTVRDM
STSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELDMPAMYSTLSAATLEEVAAARGDSYGIFQLYPSSDSELTDN
FIRRAEAAGYDALAVTLDTGTLGWRPRDLKHGYLPMLHGHCLANYTSDPRFLEIAGVRSAGELTPMHAGLVWASLFSHPG
LTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAYSNHGGRQANGGVPAIDGLAAAVEAAGSVPVTFDSGIRDG
IDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLLAEADLTMAVNCYLSLNELAVQRLS
>Mature_384_residues
MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVTALRRYGLVPRMLRDRTVRDM
STSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELDMPAMYSTLSAATLEEVAAARGDSYGIFQLYPSSDSELTDN
FIRRAEAAGYDALAVTLDTGTLGWRPRDLKHGYLPMLHGHCLANYTSDPRFLEIAGVRSAGELTPMHAGLVWASLFSHPG
LTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAYSNHGGRQANGGVPAIDGLAAAVEAAGSVPVTFDSGIRDG
IDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLLAEADLTMAVNCYLSLNELAVQRLS

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=344, Percent_Identity=37.2093023255814, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI54234014, Length=357, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI7705393, Length=357, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1790033, Length=364, Percent_Identity=31.5934065934066, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193208036, Length=357, Percent_Identity=34.453781512605, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI32566217, Length=274, Percent_Identity=32.4817518248175, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323587, Length=368, Percent_Identity=31.25, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI78707188, Length=349, Percent_Identity=34.9570200573066, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363140, Length=346, Percent_Identity=34.971098265896, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI78707190, Length=346, Percent_Identity=34.971098265896, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 41019; Mature: 41019

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVT
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
ALRRYGLVPRMLRDRTVRDMSTSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
MPAMYSTLSAATLEEVAAARGDSYGIFQLYPSSDSELTDNFIRRAEAAGYDALAVTLDTG
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECC
TLGWRPRDLKHGYLPMLHGHCLANYTSDPRFLEIAGVRSAGELTPMHAGLVWASLFSHPG
CCCCCCCCCCCCCCHHHHCHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCC
LTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAYSNHGGRQANGGVPAIDGLA
CEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHH
AAVEAAGSVPVTFDSGIRDGIDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLL
HHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHH
AEADLTMAVNCYLSLNELAVQRLS
HHCCCEEEEEEEEEHHHHHHHHCC
>Mature Secondary Structure
MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVT
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
ALRRYGLVPRMLRDRTVRDMSTSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
MPAMYSTLSAATLEEVAAARGDSYGIFQLYPSSDSELTDNFIRRAEAAGYDALAVTLDTG
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECC
TLGWRPRDLKHGYLPMLHGHCLANYTSDPRFLEIAGVRSAGELTPMHAGLVWASLFSHPG
CCCCCCCCCCCCCCHHHHCHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCC
LTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAYSNHGGRQANGGVPAIDGLA
CEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHH
AAVEAAGSVPVTFDSGIRDGIDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLL
HHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHH
AEADLTMAVNCYLSLNELAVQRLS
HHCCCEEEEEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]