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The map label for this gene is hemN [H]

Identifier: 169628753

GI number: 169628753

Start: 1691684

End: 1692850

Strand: Direct

Name: hemN [H]

Synonym: MAB_1663

Alternate gene names: 169628753

Gene position: 1691684-1692850 (Clockwise)

Preceding gene: 169628746

Following gene: 169628755

Centisome position: 33.39

GC content: 70.52

Gene sequence:

>1167_bases
GTGACTGCCACTCTGCCGCCCCTGGTGCCGGCGCCCGGGCGTCCGTTCGGGATCTACGTGCATGTGCCGTTCTGCGCCAC
ACGCTGCGGGTATTGCGATTTCAACACCTACACCGCCGACGAGCTGGGCGAGGGAACCTCGCCCGCCGGCTGGCTGGAGG
CCTTGCGTGCCGAGCTGGAGTTGGCGGCGCGAACCCTGGCGGGGAATCCGCCGGTAGAGACGGTGTTCGTCGGGGGCGGT
ACGCCGTCCCTGCTGGGTGGTTCCGGGCTCGCCGAGGTGCTCGATGCGATCGGCGCACATTTCGTGCTGGCACCCGGGGC
CGAGGTCACCACGGAGGCCAATCCCGAGTCCACCTCACCGGCTTTCTTCGACACCATCCGCGCGGCCGGGTACACCCGTG
TCTCGTTGGGCATGCAGTCCGCGGCCCCGCACGTGCTGGCAACCCTGGATCGCGTGCACGCGCCGGGACGGGCGGTGGCG
GCGGCGCGGGAGGCTCGCGCGGCCGGACTGGGGCACGTCAACCTGGACCTCATCTACGGCACCCCCGGTGAGACCGACGA
CGACCTGCGCCGGTCCATCGCCGCCGTGCTCGAGGCCGGGGTTGATCACGTGTCGGCATATGCGCTGGTGGTCGAGGAGG
GCACTGCCCTGGCGCGGCGCGTGCGCCGCGGTGAGCTGCCCAATCCCGACGAGGACGCGCTGGCCGACCGTTACCAGCTG
CTGGATGCCGCGCTCACCGAGGCCGGGCTGGACTGGTACGAGGTCTCCAACTGGGCGCGGCCCGGCGGGCAATGCCGTCA
CAACCTCGGTTACTGGGCGGGTGGTGACTGGTGGGGCGCCGGTCCGGGGGCCCATGGGCACGTCAACGGGGTGCGGTGGT
GGAACGTCAAGCACCCCAACACCTATGCCAGACGGCTACTAGGGGAAGGGCAGCTGCCAGTCGGTGGCCACGAGATCCTC
AGCCCGGTAGAGCGGCACACCGAGGAGGTGCTGCTGGCGGTCCGGCTCAACACCGGAATCGCGTTGACGGACTTGACTAT
CGAAGAACGGGGCCGCGTTCCGGCGGTGGTGGATCGCGGGCTGGGCCGGCTCGTGGACGAGCGGCTGGTGCTCACCGATC
AGGGACGACTGCTGGCCGACGGCGTGGTCCGCGCGATCCTGGACTAG

Upstream 100 bases:

>100_bases
GTGAGCAAAACCTCCATCCGGTCTGGAGGATTCCCGCCACCAACCACACAGATTTTCACTCCCGCCGTCCCTGGCACACA
CTTGACGGGTGAGGCCCGAC

Downstream 100 bases:

>100_bases
CCGGCGGTTAGACCACCCGCAGCTGATCCATGTCGAAGACCCTGGCGTGCAACACAACTCGATTGCGTAGCGCGGCCCGC
ACGGCCCGGTGCAGGCCGTC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGG
TPSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRAVA
AAREARAAGLGHVNLDLIYGTPGETDDDLRRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQL
LDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVNGVRWWNVKHPNTYARRLLGEGQLPVGGHEIL
SPVERHTEEVLLAVRLNTGIALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD

Sequences:

>Translated_388_residues
MTATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGG
TPSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRAVA
AAREARAAGLGHVNLDLIYGTPGETDDDLRRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQL
LDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVNGVRWWNVKHPNTYARRLLGEGQLPVGGHEIL
SPVERHTEEVLLAVRLNTGIALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD
>Mature_387_residues
TATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELELAARTLAGNPPVETVFVGGGT
PSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSPAFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRAVAA
AREARAAGLGHVNLDLIYGTPGETDDDLRRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQLL
DAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVNGVRWWNVKHPNTYARRLLGEGQLPVGGHEILS
PVERHTEEVLLAVRLNTGIALTDLTIEERGRVPAVVDRGLGRLVDERLVLTDQGRLLADGVVRAILD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=280, Percent_Identity=41.4285714285714, Blast_Score=181, Evalue=7e-46,
Organism=Escherichia coli, GI1789325, Length=308, Percent_Identity=36.3636363636364, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082341, Length=321, Percent_Identity=26.4797507788162, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41205; Mature: 41074

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELE
CCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHH
LAARTLAGNPPVETVFVGGGTPSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSP
HHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEECCCCCCCCCC
AFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYG
HHHHHHHHCCCEEEECCHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEC
TPGETDDDLRRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQL
CCCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHH
LDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVNGVRWWNVKHPN
HHHHHHHHCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
TYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTGIALTDLTIEERGRVPAVVDRG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEHHHCCCCCHHHHHH
LGRLVDERLVLTDQGRLLADGVVRAILD
HHHHHHCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TATLPPLVPAPGRPFGIYVHVPFCATRCGYCDFNTYTADELGEGTSPAGWLEALRAELE
CCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHH
LAARTLAGNPPVETVFVGGGTPSLLGGSGLAEVLDAIGAHFVLAPGAEVTTEANPESTSP
HHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEECCCCCCCCCC
AFFDTIRAAGYTRVSLGMQSAAPHVLATLDRVHAPGRAVAAAREARAAGLGHVNLDLIYG
HHHHHHHHCCCEEEECCHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEC
TPGETDDDLRRSIAAVLEAGVDHVSAYALVVEEGTALARRVRRGELPNPDEDALADRYQL
CCCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHH
LDAALTEAGLDWYEVSNWARPGGQCRHNLGYWAGGDWWGAGPGAHGHVNGVRWWNVKHPN
HHHHHHHHCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
TYARRLLGEGQLPVGGHEILSPVERHTEEVLLAVRLNTGIALTDLTIEERGRVPAVVDRG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEHHHCCCCCHHHHHH
LGRLVDERLVLTDQGRLLADGVVRAILD
HHHHHHCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]