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The map label for this gene is hrcA

Identifier: 169628755

GI number: 169628755

Start: 1693278

End: 1694303

Strand: Direct

Name: hrcA

Synonym: MAB_1665

Alternate gene names: 169628755

Gene position: 1693278-1694303 (Clockwise)

Preceding gene: 169628753

Following gene: 169628756

Centisome position: 33.42

GC content: 65.98

Gene sequence:

>1026_bases
ATGGCAAGTGCGGATGACCGGCGTTTCGAGGTGCTGCGCGCCATCGTCGCCGACTACGTCACCACCAAGGAGCCCATCGG
CTCCAAGGCCCTGGTCGACAGGCACGGCCTGGGCGTTTCCAGCGCCACCGTCCGCAACGATATGGCCGTGCTGGAGGCCG
AGGGTTACATCGCCCAGCCGCACACCAGCTCGGGGCGCGTTCCCACGGAAAAGGGCTACCGCGAATTCGTCAACCGGCTC
GAGGACGTCAAGCCTCTCTCGGGCGCCGAGCGCAAGGCCATCCTGAACTTCCTGGAGGGTGGCGTCGACCTCGATGACGT
GCTGCGCCGGGCGGTGCGGCTGCTGGCGCAGATGACCCGTCAGGTCGCCGTCGTGCAATATCCGACACTGTCCTCGTCCA
GTGTGCGTCATCTGGAAGTGGTGTCGCTGAGCCCGGCCCGGCTACTTCTGGTGGTCATCACCGACACCGGGCGCGTCGAT
CAGCGCATCGTCGAGCTGGGCGATGTGATCAACGATGAGCAACTTGGCCGCCTACGAGTGTTGCTCGGTGCGGCATTGGA
CGGCAAGAAGCTGTCCGCGGCCTCGGTGGCCGTGGCCGAGCTCGCCGAGCAGTCCGACGACGATCTGCGTGATCCGATCA
CCCGGGCGGCCACCGTCCTGGTGGAGACGCTCGTCGAACATCATGAGGAACGACTGCTGCTAGGTGGTACGGCCAACCTG
ACCCGCAACGCCGCCGACTTCGGTGGGCAGCTGCGCACCGTGCTGGAGGCGCTGGAGGAGCAGGTCGTGGTGCTGCGCTT
GCTCGCCGCGCAACAGGAGGCGGGCCGGGTGACCGTGCACATCGGCCACGAAACCGCGGCCGAACAGATGATTGGCACCT
CCGTCGTCTCTACCCCGTATGGTGCGGGCGGAGCGGTTTTCGGCGGCATGGGTGTGCTGGGGCCCACACGGATGGACTAC
CCGGGAACCATCGCGAATGTTGCGGCGGTTGCCATGTATATCGGCGAAGTGCTAGCTAATCGCTAG

Upstream 100 bases:

>100_bases
CTCCATAACACCTGAGATTAGCGTGGACGGCTATGGCGGCGGGGCGGAGCGGCCTGGCCCCGTAAAATAAAGGGCAAAAT
CACGCCCGAGGGAGGTGACC

Downstream 100 bases:

>100_bases
CAGCATGTGAAGTAGACAGATACCAACGGAGCGAGATCAACACAGTGGCGCGTGATTACTACGGCATCCTCGGGGTGAGC
AAGGGTGCCAGCGACAGCGA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MASADDRRFEVLRAIVADYVTTKEPIGSKALVDRHGLGVSSATVRNDMAVLEAEGYIAQPHTSSGRVPTEKGYREFVNRL
EDVKPLSGAERKAILNFLEGGVDLDDVLRRAVRLLAQMTRQVAVVQYPTLSSSSVRHLEVVSLSPARLLLVVITDTGRVD
QRIVELGDVINDEQLGRLRVLLGAALDGKKLSAASVAVAELAEQSDDDLRDPITRAATVLVETLVEHHEERLLLGGTANL
TRNAADFGGQLRTVLEALEEQVVVLRLLAAQQEAGRVTVHIGHETAAEQMIGTSVVSTPYGAGGAVFGGMGVLGPTRMDY
PGTIANVAAVAMYIGEVLANR

Sequences:

>Translated_341_residues
MASADDRRFEVLRAIVADYVTTKEPIGSKALVDRHGLGVSSATVRNDMAVLEAEGYIAQPHTSSGRVPTEKGYREFVNRL
EDVKPLSGAERKAILNFLEGGVDLDDVLRRAVRLLAQMTRQVAVVQYPTLSSSSVRHLEVVSLSPARLLLVVITDTGRVD
QRIVELGDVINDEQLGRLRVLLGAALDGKKLSAASVAVAELAEQSDDDLRDPITRAATVLVETLVEHHEERLLLGGTANL
TRNAADFGGQLRTVLEALEEQVVVLRLLAAQQEAGRVTVHIGHETAAEQMIGTSVVSTPYGAGGAVFGGMGVLGPTRMDY
PGTIANVAAVAMYIGEVLANR
>Mature_340_residues
ASADDRRFEVLRAIVADYVTTKEPIGSKALVDRHGLGVSSATVRNDMAVLEAEGYIAQPHTSSGRVPTEKGYREFVNRLE
DVKPLSGAERKAILNFLEGGVDLDDVLRRAVRLLAQMTRQVAVVQYPTLSSSSVRHLEVVSLSPARLLLVVITDTGRVDQ
RIVELGDVINDEQLGRLRVLLGAALDGKKLSAASVAVAELAEQSDDDLRDPITRAATVLVETLVEHHEERLLLGGTANLT
RNAADFGGQLRTVLEALEEQVVVLRLLAAQQEAGRVTVHIGHETAAEQMIGTSVVSTPYGAGGAVFGGMGVLGPTRMDYP
GTIANVAAVAMYIGEVLANR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_MYCA9 (B1MN38)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702404.1
- ProteinModelPortal:   B1MN38
- SMR:   B1MN38
- EnsemblBacteria:   EBMYCT00000004415
- GeneID:   5964182
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_1665
- GeneTree:   EBGT00050000016264
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   MABS561007:MAB_1665-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 36502; Mature: 36371

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASADDRRFEVLRAIVADYVTTKEPIGSKALVDRHGLGVSSATVRNDMAVLEAEGYIAQP
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHCCHHEEECCCEEECC
HTSSGRVPTEKGYREFVNRLEDVKPLSGAERKAILNFLEGGVDLDDVLRRAVRLLAQMTR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QVAVVQYPTLSSSSVRHLEVVSLSPARLLLVVITDTGRVDQRIVELGDVINDEQLGRLRV
HEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHH
LLGAALDGKKLSAASVAVAELAEQSDDDLRDPITRAATVLVETLVEHHEERLLLGGTANL
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHH
TRNAADFGGQLRTVLEALEEQVVVLRLLAAQQEAGRVTVHIGHETAAEQMIGTSVVSTPY
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCC
GAGGAVFGGMGVLGPTRMDYPGTIANVAAVAMYIGEVLANR
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASADDRRFEVLRAIVADYVTTKEPIGSKALVDRHGLGVSSATVRNDMAVLEAEGYIAQP
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHCCHHEEECCCEEECC
HTSSGRVPTEKGYREFVNRLEDVKPLSGAERKAILNFLEGGVDLDDVLRRAVRLLAQMTR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QVAVVQYPTLSSSSVRHLEVVSLSPARLLLVVITDTGRVDQRIVELGDVINDEQLGRLRV
HEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHH
LLGAALDGKKLSAASVAVAELAEQSDDDLRDPITRAATVLVETLVEHHEERLLLGGTANL
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHH
TRNAADFGGQLRTVLEALEEQVVVLRLLAAQQEAGRVTVHIGHETAAEQMIGTSVVSTPY
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCC
GAGGAVFGGMGVLGPTRMDYPGTIANVAAVAMYIGEVLANR
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA