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The map label for this gene is rsmA [H]

Identifier: 169824244

GI number: 169824244

Start: 604800

End: 605651

Strand: Direct

Name: rsmA [H]

Synonym: FMG_0547

Alternate gene names: 169824244

Gene position: 604800-605651 (Clockwise)

Preceding gene: 169824243

Following gene: 169824245

Centisome position: 33.65

GC content: 30.52

Gene sequence:

>852_bases
ATGAGTTATAAACTTCACCAACCTTCTTGTATTAAAGAAATATTGGACAAATTTGGATTCAAATTTTCAAAATCTTTGGG
CCAAAATTTTCTTATAGATGGTAATTTGATTGAAAATATTATAGATTATTCTGATATTACAGAAGACGATTACGTAATTG
AAATTGGCCCTGGTTTTGGAACATTGACAGAAAGACTTGTTGATAAATGCAAGTTCTTGTATTCGATTGAAATAGATTCA
AGACTGATGGATGTTTTGAAATATACTGTTGGCGATAGAGAAAATTTTAAAATAATAAATGAAGATGTATTGAAGGTGGA
TTTGAATGAACTTAATCATGAAGATAAAAAATTCAAAGTGGTTGCAAATCTTCCTTATTACATCACAACTCCCATTATTG
AGCACTTGTTCAATTACAGAGATATCATCGAATCAATCACTGTTATGGTTCAAAAAGAAGTGGCAAATAGAATGGTAGCT
GATGTAGGAAGTAAAGATTATGCATCATTGAGTTTGTTTGTAAAACAAAACAGCGATGCGAAAATAATACTGAATGCACC
AAAGACAGTGTTCATGCCACAACCAAAAGTAGACAGTGCAGTTGTCAATATGAAACTCAAAAAATTAGATGAAGATATTG
ACCAAGAACTTTTACGTCAATTAATAAGATCAGGCTTTAGCAAAAGAAGAAAAACCATATTGAACAGTTTCACCAGTGGA
TTTGTAAATGTCGACAAGGAAAAATTAAAGGCAATTCTTCAAGAATTGGGATTAAAGGAAAATTTAAGAGCCGAGAATTT
GTCACTAGAAGATTACAAAAATATTGTGAAAAAGTTGAGTCTAATTGATTAA

Upstream 100 bases:

>100_bases
GCAAAATCTTAAATATAGGTTACGGAAATGCGAAATCTTTTCTTAGAATGCTTAACAATTACAATATTTCAAGAGAAAAA
TTAGAGGAGGCTATAAATAG

Downstream 100 bases:

>100_bases
GATTTTCAAATAAGGGTATATATAAAATACAGACTTTTAAGGAGGTATTTTTATGAAAGATGTAGTAATTTATACAAGTG
ATGGATGCCAATATTGCCAT

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSYKLHQPSCIKEILDKFGFKFSKSLGQNFLIDGNLIENIIDYSDITEDDYVIEIGPGFGTLTERLVDKCKFLYSIEIDS
RLMDVLKYTVGDRENFKIINEDVLKVDLNELNHEDKKFKVVANLPYYITTPIIEHLFNYRDIIESITVMVQKEVANRMVA
DVGSKDYASLSLFVKQNSDAKIILNAPKTVFMPQPKVDSAVVNMKLKKLDEDIDQELLRQLIRSGFSKRRKTILNSFTSG
FVNVDKEKLKAILQELGLKENLRAENLSLEDYKNIVKKLSLID

Sequences:

>Translated_283_residues
MSYKLHQPSCIKEILDKFGFKFSKSLGQNFLIDGNLIENIIDYSDITEDDYVIEIGPGFGTLTERLVDKCKFLYSIEIDS
RLMDVLKYTVGDRENFKIINEDVLKVDLNELNHEDKKFKVVANLPYYITTPIIEHLFNYRDIIESITVMVQKEVANRMVA
DVGSKDYASLSLFVKQNSDAKIILNAPKTVFMPQPKVDSAVVNMKLKKLDEDIDQELLRQLIRSGFSKRRKTILNSFTSG
FVNVDKEKLKAILQELGLKENLRAENLSLEDYKNIVKKLSLID
>Mature_282_residues
SYKLHQPSCIKEILDKFGFKFSKSLGQNFLIDGNLIENIIDYSDITEDDYVIEIGPGFGTLTERLVDKCKFLYSIEIDSR
LMDVLKYTVGDRENFKIINEDVLKVDLNELNHEDKKFKVVANLPYYITTPIIEHLFNYRDIIESITVMVQKEVANRMVAD
VGSKDYASLSLFVKQNSDAKIILNAPKTVFMPQPKVDSAVVNMKLKKLDEDIDQELLRQLIRSGFSKRRKTILNSFTSGF
VNVDKEKLKAILQELGLKENLRAENLSLEDYKNIVKKLSLID

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=233, Percent_Identity=32.1888412017167, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI156415992, Length=288, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786236, Length=265, Percent_Identity=33.5849056603774, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25146882, Length=219, Percent_Identity=31.5068493150685, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25141369, Length=266, Percent_Identity=25.187969924812, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324989, Length=226, Percent_Identity=29.646017699115, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358017, Length=226, Percent_Identity=29.646017699115, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357273, Length=278, Percent_Identity=25.5395683453237, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32558; Mature: 32427

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKLHQPSCIKEILDKFGFKFSKSLGQNFLIDGNLIENIIDYSDITEDDYVIEIGPGFG
CCCCCCCCHHHHHHHHHHCCHHHHHCCCCEEECCHHHHHHHHHCCCCCCCEEEEECCCCH
TLTERLVDKCKFLYSIEIDSRLMDVLKYTVGDRENFKIINEDVLKVDLNELNHEDKKFKV
HHHHHHHHHHHHHHEECHHHHHHHHHHHHHCCCCCCEEECCHHHEEEHHHCCCCCCEEEE
VANLPYYITTPIIEHLFNYRDIIESITVMVQKEVANRMVADVGSKDYASLSLFVKQNSDA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCCC
KIILNAPKTVFMPQPKVDSAVVNMKLKKLDEDIDQELLRQLIRSGFSKRRKTILNSFTSG
EEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FVNVDKEKLKAILQELGLKENLRAENLSLEDYKNIVKKLSLID
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYKLHQPSCIKEILDKFGFKFSKSLGQNFLIDGNLIENIIDYSDITEDDYVIEIGPGFG
CCCCCCCHHHHHHHHHHCCHHHHHCCCCEEECCHHHHHHHHHCCCCCCCEEEEECCCCH
TLTERLVDKCKFLYSIEIDSRLMDVLKYTVGDRENFKIINEDVLKVDLNELNHEDKKFKV
HHHHHHHHHHHHHHEECHHHHHHHHHHHHHCCCCCCEEECCHHHEEEHHHCCCCCCEEEE
VANLPYYITTPIIEHLFNYRDIIESITVMVQKEVANRMVADVGSKDYASLSLFVKQNSDA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCCC
KIILNAPKTVFMPQPKVDSAVVNMKLKKLDEDIDQELLRQLIRSGFSKRRKTILNSFTSG
EEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FVNVDKEKLKAILQELGLKENLRAENLSLEDYKNIVKKLSLID
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA