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The map label for this gene is dnaX [H]

Identifier: 169824209

GI number: 169824209

Start: 579338

End: 580951

Strand: Direct

Name: dnaX [H]

Synonym: FMG_0512

Alternate gene names: 169824209

Gene position: 579338-580951 (Clockwise)

Preceding gene: 169824207

Following gene: 169824210

Centisome position: 32.23

GC content: 29.43

Gene sequence:

>1614_bases
ATGCAAGCTATTTATAGAAAATATAGGCCGGATACTTTCGACAAAGTTTACGGGCAAAAACATATAACTGATATTTTAAA
AAATCAAATCGAAACGAAAAATATTTCACATGCATACATTTTTTCAGGATCAAGAGGAACTGGTAAAACAAGTTGTGCGA
AAATTTTTGCGAGAGCTATTAACTGCTTGGATTTACAAAATGGAAATCCTTGTAACAAATGCGAAAATTGTCAGAGTTCG
TTGGAAGAATCAACATTAGATATCGTTGAAATGGATGCTGCTAGTAACAGAAGAATTGATGATATAAGAGAACTACGTGA
TAAAGTAATTTATCCACCTACAAAACTCAAATATAAAGTCTATATTATAGACGAAGCTCACATGATTACTAATGAAGGAT
TTAATGCATTACTTAAAATCATGGAAGAACCACCAAAACATTTGGTGTTCATTTTAGCCACGACTGAAATCGACAAGATT
CCACAAACTATTTTATCAAGATGTCAACGTTACGAATTCAAAATGATAAATTCTAAGGATATTTCGGATAATATCAAATA
CATTTTGAACGATTTGAATAGAAAAATGGACGACGATGCGATTGAGCTCATTGCAAATAAAGCGGATGGAGCAATGAGAG
ATGCATTATCTATTTTGGATCAAGTTTTAAGCATTGAAAAAGAAAATATAACAAAACAAGATATAAATGATATACTTGGT
ATTGTTGACAATAAAGGAATCTTCAAACTTGTTAATAGCATAATAAAAAAAGATGCTACAGATGTTTTGGGTAATTTGTA
CACAATATCACATAACAAACCTGTCGAAAATGTTATGGATGAGTTGTTGAATCATTTTAGAAACTTGTTGCTATCAAAAA
ATGGACTTGAAAAAATTAGACAGAATAACACCCAATACAATGATGATTATAATGCACAATCTGAATTAATCACTAATAGG
CAAATAGTAGAAAGCATGTCGATCATAATTGAGCATCAGAAAAAATTAAAACAGGCGGATAATCAAAAAGCTCTTCTTGA
AATTTTGGTTATGCGACTTATAGATTACATCGATTATGATGATTTGATTGCTAGAGTGAATACGTTGGAAGATAAGCTCA
ATAATATTGAACAAAATGGAATTAAAATCAATTCTACAAAAGAACTATCAGAATTTGACGAGAAAATCGATAAAAAAATA
GAAATTTCACAAAAATCTTCAAAAAAAGAAGCAAAACAAGATGAATTATCTGATAAAAATGATATAATAAAGATTGATGA
AAAAATCGACGATAAGGTAGAAGAAGTTGTCGAAAATGAGGATTCATTTGGAAAACTAAGAGAAGTTTTAAGAGAATTCG
ACAAAATTCCTAAAGAATTAGCTGATGATATCAATGCTAGTTTGGAAAATGATAGACTGATTTTGAAGACTAATCAGTTG
TATTTGTATACTTTGCTTCCTCACAAAAAAGTTATTGAACAGTTGCTTAAACCACATTACGATTTCAAGGTTTTAGATTT
ACAAATTGATAATGAGAAAGAGGAAAAAGGAAACGAAAGCGTTAAAAAATTACAGAATTTGTTTGGAAAAAATGTCCAAA
TAATTGAAAAATAG

Upstream 100 bases:

>100_bases
TTTATCAAATATGGTATAATATAAAAAGATTTAATTGTGTTTAAATTATATTAAAATTGAAAAAAATTACTCGTTGTTTA
ACAATGAAACCGAGGTACTT

Downstream 100 bases:

>100_bases
GAGGAATTATGGGAAATAAATTTAGAGGCGGAATGCCTGGCATGGGAAACATGGGAAACATGATGAAACAAATGCAAAAA
ATGCAAAGACAAATGGAAGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MQAIYRKYRPDTFDKVYGQKHITDILKNQIETKNISHAYIFSGSRGTGKTSCAKIFARAINCLDLQNGNPCNKCENCQSS
LEESTLDIVEMDAASNRRIDDIRELRDKVIYPPTKLKYKVYIIDEAHMITNEGFNALLKIMEEPPKHLVFILATTEIDKI
PQTILSRCQRYEFKMINSKDISDNIKYILNDLNRKMDDDAIELIANKADGAMRDALSILDQVLSIEKENITKQDINDILG
IVDNKGIFKLVNSIIKKDATDVLGNLYTISHNKPVENVMDELLNHFRNLLLSKNGLEKIRQNNTQYNDDYNAQSELITNR
QIVESMSIIIEHQKKLKQADNQKALLEILVMRLIDYIDYDDLIARVNTLEDKLNNIEQNGIKINSTKELSEFDEKIDKKI
EISQKSSKKEAKQDELSDKNDIIKIDEKIDDKVEEVVENEDSFGKLREVLREFDKIPKELADDINASLENDRLILKTNQL
YLYTLLPHKKVIEQLLKPHYDFKVLDLQIDNEKEEKGNESVKKLQNLFGKNVQIIEK

Sequences:

>Translated_537_residues
MQAIYRKYRPDTFDKVYGQKHITDILKNQIETKNISHAYIFSGSRGTGKTSCAKIFARAINCLDLQNGNPCNKCENCQSS
LEESTLDIVEMDAASNRRIDDIRELRDKVIYPPTKLKYKVYIIDEAHMITNEGFNALLKIMEEPPKHLVFILATTEIDKI
PQTILSRCQRYEFKMINSKDISDNIKYILNDLNRKMDDDAIELIANKADGAMRDALSILDQVLSIEKENITKQDINDILG
IVDNKGIFKLVNSIIKKDATDVLGNLYTISHNKPVENVMDELLNHFRNLLLSKNGLEKIRQNNTQYNDDYNAQSELITNR
QIVESMSIIIEHQKKLKQADNQKALLEILVMRLIDYIDYDDLIARVNTLEDKLNNIEQNGIKINSTKELSEFDEKIDKKI
EISQKSSKKEAKQDELSDKNDIIKIDEKIDDKVEEVVENEDSFGKLREVLREFDKIPKELADDINASLENDRLILKTNQL
YLYTLLPHKKVIEQLLKPHYDFKVLDLQIDNEKEEKGNESVKKLQNLFGKNVQIIEK
>Mature_537_residues
MQAIYRKYRPDTFDKVYGQKHITDILKNQIETKNISHAYIFSGSRGTGKTSCAKIFARAINCLDLQNGNPCNKCENCQSS
LEESTLDIVEMDAASNRRIDDIRELRDKVIYPPTKLKYKVYIIDEAHMITNEGFNALLKIMEEPPKHLVFILATTEIDKI
PQTILSRCQRYEFKMINSKDISDNIKYILNDLNRKMDDDAIELIANKADGAMRDALSILDQVLSIEKENITKQDINDILG
IVDNKGIFKLVNSIIKKDATDVLGNLYTISHNKPVENVMDELLNHFRNLLLSKNGLEKIRQNNTQYNDDYNAQSELITNR
QIVESMSIIIEHQKKLKQADNQKALLEILVMRLIDYIDYDDLIARVNTLEDKLNNIEQNGIKINSTKELSEFDEKIDKKI
EISQKSSKKEAKQDELSDKNDIIKIDEKIDDKVEEVVENEDSFGKLREVLREFDKIPKELADDINASLENDRLILKTNQL
YLYTLLPHKKVIEQLLKPHYDFKVLDLQIDNEKEEKGNESVKKLQNLFGKNVQIIEK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=265, Percent_Identity=27.1698113207547, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI31881687, Length=265, Percent_Identity=27.1698113207547, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI6677723, Length=266, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI194306571, Length=266, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194306567, Length=266, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI31563534, Length=235, Percent_Identity=28.0851063829787, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786676, Length=263, Percent_Identity=39.5437262357414, Blast_Score=242, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17554730, Length=266, Percent_Identity=24.0601503759398, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=301, Percent_Identity=22.9235880398671, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=235, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=275, Percent_Identity=25.8181818181818, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324039, Length=218, Percent_Identity=27.9816513761468, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=261, Percent_Identity=26.8199233716475, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI18859927, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921076, Length=249, Percent_Identity=24.4979919678715, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62141; Mature: 62141

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIYRKYRPDTFDKVYGQKHITDILKNQIETKNISHAYIFSGSRGTGKTSCAKIFARAI
CCCHHHHCCCCHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
NCLDLQNGNPCNKCENCQSSLEESTLDIVEMDAASNRRIDDIRELRDKVIYPPTKLKYKV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCCEEEEE
YIIDEAHMITNEGFNALLKIMEEPPKHLVFILATTEIDKIPQTILSRCQRYEFKMINSKD
EEEECCHHHHHCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCC
ISDNIKYILNDLNRKMDDDAIELIANKADGAMRDALSILDQVLSIEKENITKQDINDILG
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IVDNKGIFKLVNSIIKKDATDVLGNLYTISHNKPVENVMDELLNHFRNLLLSKNGLEKIR
HHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
QNNTQYNDDYNAQSELITNRQIVESMSIIIEHQKKLKQADNQKALLEILVMRLIDYIDYD
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHH
DLIARVNTLEDKLNNIEQNGIKINSTKELSEFDEKIDKKIEISQKSSKKEAKQDELSDKN
HHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHCCCCC
DIIKIDEKIDDKVEEVVENEDSFGKLREVLREFDKIPKELADDINASLENDRLILKTNQL
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCE
YLYTLLPHKKVIEQLLKPHYDFKVLDLQIDNEKEEKGNESVKKLQNLFGKNVQIIEK
EEEEECCHHHHHHHHHCCCCCEEEEEEEECCCHHHCCHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MQAIYRKYRPDTFDKVYGQKHITDILKNQIETKNISHAYIFSGSRGTGKTSCAKIFARAI
CCCHHHHCCCCHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
NCLDLQNGNPCNKCENCQSSLEESTLDIVEMDAASNRRIDDIRELRDKVIYPPTKLKYKV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCCEEEEE
YIIDEAHMITNEGFNALLKIMEEPPKHLVFILATTEIDKIPQTILSRCQRYEFKMINSKD
EEEECCHHHHHCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCC
ISDNIKYILNDLNRKMDDDAIELIANKADGAMRDALSILDQVLSIEKENITKQDINDILG
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IVDNKGIFKLVNSIIKKDATDVLGNLYTISHNKPVENVMDELLNHFRNLLLSKNGLEKIR
HHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
QNNTQYNDDYNAQSELITNRQIVESMSIIIEHQKKLKQADNQKALLEILVMRLIDYIDYD
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHH
DLIARVNTLEDKLNNIEQNGIKINSTKELSEFDEKIDKKIEISQKSSKKEAKQDELSDKN
HHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHCCCCC
DIIKIDEKIDDKVEEVVENEDSFGKLREVLREFDKIPKELADDINASLENDRLILKTNQL
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCE
YLYTLLPHKKVIEQLLKPHYDFKVLDLQIDNEKEEKGNESVKKLQNLFGKNVQIIEK
EEEEECCHHHHHHHHHCCCCCEEEEEEEECCCHHHCCHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]