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The map label for this gene is pepQ [H]

Identifier: 169824071

GI number: 169824071

Start: 426797

End: 428566

Strand: Direct

Name: pepQ [H]

Synonym: FMG_0374

Alternate gene names: 169824071

Gene position: 426797-428566 (Clockwise)

Preceding gene: 169824070

Following gene: 169824072

Centisome position: 23.74

GC content: 34.8

Gene sequence:

>1770_bases
ATGATTAAAGAAAGATTAGAAAAGCTAAGAAAAAAAATGAGCGAAAGAAATATCGATGCATATGTTGTATTGTCAAGCGA
TCCTCATACATCGGAATATTTAGCAGATTACTATAAAACTAGAAAATATATTACTGGATTTAGTGGCAGTGCAGGTACTG
CTGTAATTTTGAAGAAAAAAGCAGCTTTGTTTACTGACGGAAGATATTTTATCCAAGCTGCAAAGGAGCTTGAAGGTTCT
ACTGTAGATTTGATGAAGATGGGTGAACCTGGAGTTCCAACTTTGATTGAATATTTGAAAGAAAATGTTGGTGAATGCGG
AAAAATCGGAGTTGATGGTCTTACTTTGGATTACAATGATTATTATAGATGGTTAGAAAATCTTGGCGACAGGATGATAA
TCACTGATGTTGATTTTATTGGTGATATCTGGGAAGATCGTCCTGAAAAACCAAACTCAAAAGCTTATGCATTTGATGTA
AAATACTGTGGAAAAGATACGAAGACCAAATTAAAAGAGTTGAGATATTTCATGGATTGCAATGAATGTGATTATAACTT
TATCGGTTCTTTGGATGATATTTGCTACCTTTACAATATTAGAGGTAACGATGTTTTGTATAGTCCGGTTATCATAAGTT
ATGCATTAGTTGGAAAAGATTTTGCTAATTTGTACATTGAAGATGAAAAAATCGATGACGATTTGATTGAATTGTTGAAA
GAACAAGGTGTTACTGTAAAATCTTACGAAAAAGTGTTCGAAGATTTGAGCGAACTTCCTGGTAAGAGCGTTTTGTTCTT
GGATCCTTCTAAGACAAATGTTAGAATTTACAATTCAATTAATTCTAATATCAGAATTTCAAAAGGAATTCAACCTACAA
CTTTGATGAAGGCTCACAAGAATGAAACAGAAATTAAAAATCAAAAGAATGCCTATATCAAAGACGGTGTTGCATTGGTT
AAGTTTTTCAATTGGGTAGAAACAGGTACTCCAACTGGAAATGTTACTGAAATGAGTGCAGCGGATAAGTTGAGATATTT
CAGAGAACAAGGAGATTTGTTCATGGATTTGAGTTTCGGTACAATATCAGCTTACGGAGAAAACGCAGCACTTCCTCATT
ACTCACCATCAGTAGACCATCCAGTGACATTACAACCGAAGGGATTGTACTTGGTTGACAGTGGTGCGCAATATTTGGAT
GGAACAACTGATATTACTCGTACGGTTGCTCTTGGTGAGTTGACAGATGATGAAAAACTTCACTATACTTTAACATTAAA
ATCACACATCAATTTGATGACTACAATTTTCCCTAAAGGAACAAAATCATCAAGCTTGGATCCAATTGCTAGAAGACCAA
TTTGGCAAGAATTGTTGGACTTCAGACATGGAACAGGCCACGGTGTTGGATTCTACCTTGGAGTTCACGAAGGTCCACAA
AGAATTGCATCTGTAAACAATGATATCGATATGGATGAAGGAATGGTTACAAGCGACGAACCAGGAATTTACATCGAAGG
TTCACACGGAATCAGAATCGAAAATATTATGCATTGTATCAAAGTTGGAGAATCTGAATTCGGTGAGTTCTTGGGATTTG
AATCATTATCTATCTGTCCAATTGACACAAGACCAGTTATCAAAGAAAAATTACTTCCTTTCGAATTAGAATGGTTGAAC
AATTACAACAAAGAATGCTACGACAAATTATCACCTTATTTGGAAGGATCTGACTTAGAATATCTTGAACAACAAACAAA
AGCAATATAG

Upstream 100 bases:

>100_bases
TTTACAAACTAGGTATTAATTTACCTAGTTTTTTTGTTAGCGTGAAAATAAACATCGTTAAATTTTGTGATATAATTATT
ATAACTACGAGGAGGTAATT

Downstream 100 bases:

>100_bases
AAATGTTTGATATTAAAAAAGAACTGCAAAAAGTACCTCACAAACCAGGCGTGTACATTATGCACGATAAAAACGATGAG
ATAATCTACGTTGGTAAGGC

Product: putative X-prolyl aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MIKERLEKLRKKMSERNIDAYVVLSSDPHTSEYLADYYKTRKYITGFSGSAGTAVILKKKAALFTDGRYFIQAAKELEGS
TVDLMKMGEPGVPTLIEYLKENVGECGKIGVDGLTLDYNDYYRWLENLGDRMIITDVDFIGDIWEDRPEKPNSKAYAFDV
KYCGKDTKTKLKELRYFMDCNECDYNFIGSLDDICYLYNIRGNDVLYSPVIISYALVGKDFANLYIEDEKIDDDLIELLK
EQGVTVKSYEKVFEDLSELPGKSVLFLDPSKTNVRIYNSINSNIRISKGIQPTTLMKAHKNETEIKNQKNAYIKDGVALV
KFFNWVETGTPTGNVTEMSAADKLRYFREQGDLFMDLSFGTISAYGENAALPHYSPSVDHPVTLQPKGLYLVDSGAQYLD
GTTDITRTVALGELTDDEKLHYTLTLKSHINLMTTIFPKGTKSSSLDPIARRPIWQELLDFRHGTGHGVGFYLGVHEGPQ
RIASVNNDIDMDEGMVTSDEPGIYIEGSHGIRIENIMHCIKVGESEFGEFLGFESLSICPIDTRPVIKEKLLPFELEWLN
NYNKECYDKLSPYLEGSDLEYLEQQTKAI

Sequences:

>Translated_589_residues
MIKERLEKLRKKMSERNIDAYVVLSSDPHTSEYLADYYKTRKYITGFSGSAGTAVILKKKAALFTDGRYFIQAAKELEGS
TVDLMKMGEPGVPTLIEYLKENVGECGKIGVDGLTLDYNDYYRWLENLGDRMIITDVDFIGDIWEDRPEKPNSKAYAFDV
KYCGKDTKTKLKELRYFMDCNECDYNFIGSLDDICYLYNIRGNDVLYSPVIISYALVGKDFANLYIEDEKIDDDLIELLK
EQGVTVKSYEKVFEDLSELPGKSVLFLDPSKTNVRIYNSINSNIRISKGIQPTTLMKAHKNETEIKNQKNAYIKDGVALV
KFFNWVETGTPTGNVTEMSAADKLRYFREQGDLFMDLSFGTISAYGENAALPHYSPSVDHPVTLQPKGLYLVDSGAQYLD
GTTDITRTVALGELTDDEKLHYTLTLKSHINLMTTIFPKGTKSSSLDPIARRPIWQELLDFRHGTGHGVGFYLGVHEGPQ
RIASVNNDIDMDEGMVTSDEPGIYIEGSHGIRIENIMHCIKVGESEFGEFLGFESLSICPIDTRPVIKEKLLPFELEWLN
NYNKECYDKLSPYLEGSDLEYLEQQTKAI
>Mature_589_residues
MIKERLEKLRKKMSERNIDAYVVLSSDPHTSEYLADYYKTRKYITGFSGSAGTAVILKKKAALFTDGRYFIQAAKELEGS
TVDLMKMGEPGVPTLIEYLKENVGECGKIGVDGLTLDYNDYYRWLENLGDRMIITDVDFIGDIWEDRPEKPNSKAYAFDV
KYCGKDTKTKLKELRYFMDCNECDYNFIGSLDDICYLYNIRGNDVLYSPVIISYALVGKDFANLYIEDEKIDDDLIELLK
EQGVTVKSYEKVFEDLSELPGKSVLFLDPSKTNVRIYNSINSNIRISKGIQPTTLMKAHKNETEIKNQKNAYIKDGVALV
KFFNWVETGTPTGNVTEMSAADKLRYFREQGDLFMDLSFGTISAYGENAALPHYSPSVDHPVTLQPKGLYLVDSGAQYLD
GTTDITRTVALGELTDDEKLHYTLTLKSHINLMTTIFPKGTKSSSLDPIARRPIWQELLDFRHGTGHGVGFYLGVHEGPQ
RIASVNNDIDMDEGMVTSDEPGIYIEGSHGIRIENIMHCIKVGESEFGEFLGFESLSICPIDTRPVIKEKLLPFELEWLN
NYNKECYDKLSPYLEGSDLEYLEQQTKAI

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=619, Percent_Identity=38.4491114701131, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI264681565, Length=619, Percent_Identity=36.6720516962843, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI93141226, Length=600, Percent_Identity=32.3333333333333, Blast_Score=326, Evalue=3e-89,
Organism=Escherichia coli, GI1788728, Length=195, Percent_Identity=33.8461538461538, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=615, Percent_Identity=35.2845528455285, Blast_Score=339, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI25149105, Length=572, Percent_Identity=27.7972027972028, Blast_Score=206, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322999, Length=647, Percent_Identity=33.693972179289, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17137632, Length=591, Percent_Identity=35.8714043993232, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI161078230, Length=586, Percent_Identity=29.3515358361775, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI21357287, Length=586, Percent_Identity=29.3515358361775, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66771; Mature: 66771

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKERLEKLRKKMSERNIDAYVVLSSDPHTSEYLADYYKTRKYITGFSGSAGTAVILKKK
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHEECCCCCCCCEEEEEEC
AALFTDGRYFIQAAKELEGSTVDLMKMGEPGVPTLIEYLKENVGECGKIGVDGLTLDYND
HHEEECCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEECHHH
YYRWLENLGDRMIITDVDFIGDIWEDRPEKPNSKAYAFDVKYCGKDTKTKLKELRYFMDC
HHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCC
NECDYNFIGSLDDICYLYNIRGNDVLYSPVIISYALVGKDFANLYIEDEKIDDDLIELLK
CCCCCCCCCCCCCEEEEEEECCCCEEECHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHH
EQGVTVKSYEKVFEDLSELPGKSVLFLDPSKTNVRIYNSINSNIRISKGIQPTTLMKAHK
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCHHHHHHCC
NETEIKNQKNAYIKDGVALVKFFNWVETGTPTGNVTEMSAADKLRYFREQGDLFMDLSFG
CHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCC
TISAYGENAALPHYSPSVDHPVTLQPKGLYLVDSGAQYLDGTTDITRTVALGELTDDEKL
EEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCHHCCCCCHHHHEEEECCCCCCCEE
HYTLTLKSHINLMTTIFPKGTKSSSLDPIARRPIWQELLDFRHGTGHGVGFYLGVHEGPQ
EEEEEEHHCCCEEEEECCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHH
RIASVNNDIDMDEGMVTSDEPGIYIEGSHGIRIENIMHCIKVGESEFGEFLGFESLSICP
HHHHCCCCCCCCCCEEECCCCCEEEECCCCEEHHHHHHHHHCCCHHHHHHHCCCCCEEEC
IDTRPVIKEKLLPFELEWLNNYNKECYDKLSPYLEGSDLEYLEQQTKAI
CCCCHHHHHHCCCEEEHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MIKERLEKLRKKMSERNIDAYVVLSSDPHTSEYLADYYKTRKYITGFSGSAGTAVILKKK
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHEECCCCCCCCEEEEEEC
AALFTDGRYFIQAAKELEGSTVDLMKMGEPGVPTLIEYLKENVGECGKIGVDGLTLDYND
HHEEECCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEECHHH
YYRWLENLGDRMIITDVDFIGDIWEDRPEKPNSKAYAFDVKYCGKDTKTKLKELRYFMDC
HHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCC
NECDYNFIGSLDDICYLYNIRGNDVLYSPVIISYALVGKDFANLYIEDEKIDDDLIELLK
CCCCCCCCCCCCCEEEEEEECCCCEEECHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHH
EQGVTVKSYEKVFEDLSELPGKSVLFLDPSKTNVRIYNSINSNIRISKGIQPTTLMKAHK
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCHHHHHHCC
NETEIKNQKNAYIKDGVALVKFFNWVETGTPTGNVTEMSAADKLRYFREQGDLFMDLSFG
CHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCC
TISAYGENAALPHYSPSVDHPVTLQPKGLYLVDSGAQYLDGTTDITRTVALGELTDDEKL
EEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCHHCCCCCHHHHEEEECCCCCCCEE
HYTLTLKSHINLMTTIFPKGTKSSSLDPIARRPIWQELLDFRHGTGHGVGFYLGVHEGPQ
EEEEEEHHCCCEEEEECCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHH
RIASVNNDIDMDEGMVTSDEPGIYIEGSHGIRIENIMHCIKVGESEFGEFLGFESLSICP
HHHHCCCCCCCCCCEEECCCCCEEEECCCCEEHHHHHHHHHCCCHHHHHHHCCCCCEEEC
IDTRPVIKEKLLPFELEWLNNYNKECYDKLSPYLEGSDLEYLEQQTKAI
CCCCHHHHHHCCCEEEHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]